Literature summary for 3.1.4.35 extracted from

Gotshall, R.W.; Hamilton, K.L.; Foreman, B.; van Patot, M.C.; Irwin, D.C.
Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition (2009), Crit. Care Med., 37, 1988-1993.

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Application

Application	Comment	Organism
medicine	phosphodiesterase-5 inhibitors promote nitric oxide activity and enhance vasodilation. Infusion of PDE5 inhibitor sildenafil alone reduceds systemic and pulmonary artery blood pressure, while maintaining cardiac output and oxygen delivery. Combined hemoglobin-based oxygen carriers and sildenafil infusion results in stable systemic blood pressure, cardiac output, and oxygen delivery	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	PDE5 inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Synonyms

Synonyms	Comment	Organism
PDE5	-	Rattus norvegicus
phosphodiesterase-5	-	Rattus norvegicus

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Release 2023.1 (January 2023)