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Literature summary for 3.1.4.35 extracted from

  • Schaefer, S.; Ellinghaus, P.; Janssen, W.; Kramer, F.; Lustig, K.; Milting, H.; Kast, R.; Klein, M.
    Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling (2009), Cardiovasc. Res., 82, 30-39.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibition of PDE5 decreases pulmonary pressure and improves symptoms in patients with pulmonary arterial hypertension Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
sildenafil
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cGMP + H2O Rattus norvegicus
-
5'-GMP
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
Rattus norvegicus 5'-GMP
-
?

Synonyms

Synonyms Comment Organism
PDE5
-
Rattus norvegicus
phosphodiesterase 5
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular myocardial remodeling Rattus norvegicus