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Literature summary for 3.1.4.35 extracted from

  • Ni, X.P.; Safai, M.; Gardner, D.G.; Humphreys, M.H.
    Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation (2001), Kidney Int., 59, 1264-1273.
    View publication on PubMed
Search for more literature for 3.1.4.35

Inhibitors

Inhibitors Comment Organism Structure
1,3-dimethyl-6-(2-propoxy-5-methanesulfonylamidophenyl)pyrazol[3,4d]-pyrimidin-4-(5H)-one 0.000006 mM, 50% inhibition in sham operated rats Rattus norvegicus
zaprinast 0.00046 mM, 50% inhibition in sham-operated rats Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
guanosine 3',5'-cyclic phosphate + H2O Rattus norvegicus
-
 guanosine 5'-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney inner medullary collecting duct cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanosine 3',5'-cyclic phosphate + H2O
-
 Rattus norvegicus guanosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
cGMP phosphodiesterase
-
 Rattus norvegicus
PDE5
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000045
-
 1,3-dimethyl-6-(2-propoxy-5-methanesulfonylamidophenyl)pyrazol[3,4d]-pyrimidin-4-(5H)-one sham-operated rats Rattus norvegicus
0.00031
-
 zaprinast sham-operated rats Rattus norvegicus