Literature summary for 3.1.4.35 extracted from

Nagendran, J.; Archer, S.L.; Soliman, D.; Gurtu, V.; Moudgil, R.; Haromy, A.; St Aubin, C.; Webster, L.; Rebeyka, I.M.; Ross, D.B.; Light, P.E.; Dyck, J.R.; Michelakis, E.D.
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility (2007), Circulation, 116, 238-248.

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Application

Application	Comment	Organism
medicine	enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied human right ventricle	Homo sapiens
medicine	enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied myocardium. Inhibition by sildenafil or MY-5445 significantly increases contractility in hypertrophied myocardium, but not in normal. Protein kinase G is suppressed in hypertrophied myocardium	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
MY-5445	inhibition significantly increases contractility in hypertrophied myocardium	Rattus norvegicus
sildenafil	inhibition significantly increases contractility in hypertrophied myocardium	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform PDE5	-
Rattus norvegicus	-	isoform PDE5	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied human right ventricle	Homo sapiens	-
heart	enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied right ventricle	Rattus norvegicus	-

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Release 2023.1 (January 2023)