Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.35 extracted from

  • Liu, C.Q.; Leung, F.P.; Lee, V.W.; Lau, C.W.; Yao, X.; Lu, L.; Huang, Y.
    Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor (2008), Eur. J. Pharmacol., 590, 250-254.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibition of PDE5 with T0156 prevents the reduced production of cyclic GMP and relaxation in tolerant aortas in response to nitroglycerin Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information not affected by cilostazol and rolipram Rattus norvegicus
T0156 selective phosphodiesterase type 5 inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Rattus norvegicus
-
vascular smooth muscle cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
Rattus norvegicus 5'-GMP
-
?

Synonyms

Synonyms Comment Organism
PDE5
-
Rattus norvegicus
phosphodiesterase type 5
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus nitroglycerin tolerance may involve an increased activity of PDE5 up