Application | Comment | Organism |
---|---|---|
medicine | inhibition of PDE5 with T0156 prevents the reduced production of cyclic GMP and relaxation in tolerant aortas in response to nitroglycerin | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not affected by cilostazol and rolipram | Rattus norvegicus | |
T0156 | selective phosphodiesterase type 5 inhibitor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Rattus norvegicus | - |
vascular smooth muscle cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE5 | - |
Rattus norvegicus |
phosphodiesterase type 5 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | nitroglycerin tolerance may involve an increased activity of PDE5 | up |