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Brain-derived phosphatase
-
-
-
-
CD45 protein tyrosine phosphatase
-
-
Cdc25-like protein
-
-
-
-
CDK2-associated dual specificity phosphatase
-
-
-
-
Dual specificity phosphatase Cdc25A
-
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
-
ES cell phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
-
HPTP beta-like tyrosine phosphatase
-
-
-
-
Islet cell autoantigen related protein
-
-
-
-
kinase associated phosphatase
-
-
-
-
kinase interaction motif-containing protein tyrosine phosphatases
-
-
LCA-related phosphatase
-
-
-
-
leucocyte common antigen-related protein tyrosine phosphatase
-
-
Leukocyte antigen related
-
-
-
-
Low molecular weight cytosolic acid phosphatase
-
-
-
-
Lymphoid phosphatase
-
-
-
-
MAP-kinase phosphatase CPG21
-
-
-
-
Mitosis initiation protein
-
-
-
-
Mitosis initiation protein MIH1
-
-
-
-
Mitotic inducer homolog
-
-
-
-
MKP-1 like protein tyrosine phosphatase
-
-
-
-
Neural-specific protein-tyrosine phosphatase
-
-
-
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
-
phosphatase, phosphotyrosine
-
-
-
-
phosphoprotein phosphatase (phosphotyrosine)
-
-
-
-
phosphotyrosine histone phosphatase
-
-
-
-
phosphotyrosine phosphatase
-
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
-
phosphotyrosine protein phosphatase
-
-
-
-
phosphotyrosylprotein phosphatase
-
-
-
-
protein phosphotyrosine phosphatase
-
-
-
-
protein tyrosine phosphatase
-
-
protein tyrosine phosphatase 1B
-
-
protein tyrosine phosphatase eta
-
-
protein tyrosine phosphatase ny
-
-
protein tyrosine phosphatase xi
-
-
Protein tyrosine phosphatase-NP
-
-
-
-
protein tyrosine phosphatase-PEST
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
-
Protein-tyrosine phosphatase 1B
-
-
-
-
Protein-tyrosine phosphatase 1C
-
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
-
Protein-tyrosine phosphatase CL100
-
-
-
-
Protein-tyrosine phosphatase D1
-
-
-
-
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
-
PTPetaCD
-
catalytic domain of protein tyrosine phosphatase eta
PY protein phosphatase
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
-
RNA/RNP complex-intereracting phosphatase
-
-
-
-
Small tyrosine phosphatase
-
-
-
-
Small, acidic phosphotyrosine protein phosphatase
-
-
-
-
STEP33
-
STEP is processed into a 33 kDa isoform by calpain-mediated cleavage, STEP33 retains catalytic activity but is unable to bind to phosphorylated ERK
STEP46
-
recombinant enzyme
STEP61
-
STEP61 is the normally expressed enzyme form
striatal enriched protein tyrosine phosphatase
-
-
T-cell protein tyrosine phosphatase
-
-
T-cell protein-tyrosine phosphatase
-
-
-
-
Testis-and skeletal-muscle-specific DSP
-
-
-
-
tyrosine O-phosphate phosphatase
-
-
-
-
Tyrosine phosphatase CBPTP
-
-
-
-
tyrosine-specific MAPK phosphatase
-
-
tyrosylprotein phosphatase
-
-
-
-
[phosphotyrosine]protein phosphatase
-
-
-
-
STEP
-
-
-
-
TCPTP
-
-
-
-
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
DRVpYIHPFHL + H2O
DRVYIHPFHL + phosphate
-
-
-
?
1-naphthyl phosphate + H2O
1-naphthol + phosphate
-
-
-
-
?
4-methylumbelliferyl phosphate + H2O
4-methylumbelliferone + phosphate
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
-
?
phenyl phosphate + H2O
phenol + phosphate
-
-
-
-
?
phosphorylated ERK + H2O
ERK + phosphate
-
the cleavage of STEP leads to a catalytically active form, but this cleaved form no longer binds to and dephosphorylates its substrate phosphorylated ERK
-
-
?
phosphorylated extracellular signal-regulated kinase 1 + H2O
extracellular signal-regulated kinase 1 + phosphate
-
-
-
-
?
phosphorylated extracellular signal-regulated kinase 2 + H2O
extracellular signal-regulated kinase 2 + phosphate
-
-
-
-
?
phosphoserine + H2O
serine + phosphate
-
-
-
-
?
phosphothreonine + H2O
threonine + phosphate
-
-
-
-
?
phosphotyrosine + H2O
tyrosine + phosphate
phosphotyrosine serum albumin + H2O
? + phosphate
-
-
-
-
?
phosphotyrosyl histone + H2O
? + phosphate
-
-
-
-
?
poly(Glu,Tyr) + H2O
? + phosphate
-
-
-
-
?
tyrosine-phosphorylated Raytide + H2O
Raytide + phosphate
-
-
-
?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
-
-
-
-
?
additional information
?
-
phosphotyrosine + H2O
tyrosine + phosphate
-
-
-
-
?
phosphotyrosine + H2O
tyrosine + phosphate
-
best substrate
-
-
?
additional information
?
-
-
inactive towards phosphoseryl histone
-
-
?
additional information
?
-
-
acts specifically on phosphorylated tyrosine
-
?
additional information
?
-
-
protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity
-
-
?
additional information
?
-
-
LAR, PTPalpha and PTP1B may act upon cell surface insulin receptors
-
?
additional information
?
-
-
enzyme activity is correlated with sperm thiol status and tyrosine phosphorylation of sperm proteins during maturation is promoted by thiol oxidation and diminished enzyme
-
-
?
additional information
?
-
-
enzyme isoform Shp2 is required for complete activation of mitogen-activated protein kinases MAPKs by brain-derived neurotropic factor
-
-
?
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p-hydroxymercuribenzoate
-
4-chloro-N-(6-ethoxy-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-chloro-N-(6-methoxy-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-chloro-N-(6-methyl-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-chloro-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-fluoro-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-methoxy-N-(6-methoxy-1,3-benzothiazol -2-yl)benzenesulfonamide
-
-
4-methoxy-N-(6-methyl-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-methoxy-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-methyl-N-(6-methyl-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-methyl-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
4-nitro-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
JTT-551
-
i.e. monosodium (([5-(1,1-dimethylethyl)thiazol-2-yl]methyl) ([(4-(4-[4-(1-propylbutyl)phenoxy]methyl)phenyl)thiazol-2-yl]methyl)amino)acetate, a specific protein tyrosine phosphatase 1B inhibitor in vitro and in vivo, mixed-type inhibition mode versus PTPB1, overview. The inhibitor shows a hypoglycaemic effect in rat L6 cells, overview
molybdate
-
no effect on PTP-I, PTP-III inhibited
N-(4-([(6-ethoxy-1,3-benzothiazol-2-yl)amino]sulfonyl)phenyl)acetamide
-
-
N-(4-([(6-methoxy-1,3-benzothiazol-2-yl)amino]sulfonyl)phenyl)acetamide
-
-
N-(4-([(6-methyl-1,3-benzothiazol-2-yl)amino]sulfonyl)phenyl)acetamide
-
-
N-(4-[[(6-nitro-1,3-benzothiazol-2-yl)amino]sulfonyl]-phenyl)acetamide
-
-
N-(6-chloro-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
-
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-methoxybenzenesulfonamide
-
-
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-methylbenzenesulfonamide
-
-
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-nitrobenzene sulfonamide
-
linear mixed-type inhibition, shows in vivo antihyperglycemic activity
N-(6-ethoxy-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
N-(6-fluoro-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
-
N-(6-methoxy-1,3-benzothiazol-2-yl)-4-methylbenzenesulfonamide
-
-
N-(6-methoxy-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
-
N-(6-methoxy-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
N-(6-methyl-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
linear mixed-type inhibition, shows in vivo antihyperglycemic activity
N-(6-methyl-1,3-benzothiazol-2-yl)benzenesulfonamide
-
-
potassium bisperoxo(1,10-phenanthroline)oxovanadate(V)
-
i.e. [bpV(phen)], the peroxovanadium compound is a stable, potent and selective protein tyrosine phosphatase inhibitor. It protects dorsal column sensory axons and white matter and rescues sensory-evoked potentials in vivo after treatement with PTP or spinal cord injury, overview
regucalcin
-
regulatory protein in intracellular signaling
-
H3VO4
-
-
H3VO4
-
no effect on PTP-I but PTP-III inhibited
additional information
-
in absence of externally added Ca2+, no effect of ethylene glycol bis(2-amino-ethylether) N,N,N,N-tetracetic acid or trifluoperazine. Not inhibitory: okadaic acid
-
additional information
-
inhibitor docking studies with PTP-1B, overview
-
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Tamura, S.; Suzuki, Y.; Kikuchi, K.; Tsuiki, S.
Identification and characterization of Mg2+-dependent phosphotyrosyl protein phosphatase from rat liver cytosol
Biochem. Biophys. Res. Commun.
140
212-218
1986
Rattus norvegicus
brenda
Okada, M.; Owada, K.; Nakagawa, H.
[Phosphotyrosine]protein phosphatase in rat brain. A major [phosphotyrosine]protein phosphatase is a 23 kDa protein distinct from acid phosphatase
Biochem. J.
239
155-162
1986
Rattus norvegicus
brenda
Brunati, A.M.; Pinna, L.A.
Isolation and partial characterization of distinct species of phosphotyrosyl protein phosphatases from rat spleen
Biochem. Biophys. Res. Commun.
133
929-936
1985
Rattus norvegicus
brenda
Gallis, B.; Bornstein, P.; Brautigan., D.L.
Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells
Proc. Natl. Acad. Sci. USA
78
6689-6693
1981
Rattus norvegicus
brenda
Foulkes, J.G.; Howard, R.F.; Ziemiecki, A.
Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine
FEBS Lett.
130
197-200
1981
Rattus norvegicus
brenda
Foulkes, J.G.
Phosphotyrosyl-protein phosphatases
Curr. Top. Microbiol. Immunol.
107
163-180
1983
Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Nishiwaki, T.; Maeda, N.; Noda, M.
Characterization and developmental regulation of proteoglycan-type protein-tyrosine phosphatase xi/RPTPbeta isoforms
J. Biochem.
123
458-467
1998
Rattus norvegicus
brenda
Shintani, T.; Maeda, N.; Nishiwaki, T.; Noda, M.
Characterization of rat receptor-like protein tyrosine phosphatase gamma isoforms
Biochem. Biophys. Res. Commun.
230
419-4235
1997
Rattus norvegicus
brenda
Zhang, Z.Y.
Kinetic and mechanistic characterization of a mammalian protein-tyrosine phosphatase, PTP1
J. Biol. Chem.
270
11199-11204
1995
Rattus norvegicus
brenda
Pot, D.A.; Woodford, T.A.; Remboutsika, E.; Haun, R.S.; Dixon, J.E.
Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase
J. Biol. Chem.
266
19688-19696
1991
Rattus norvegicus (Q64604)
brenda
Chengalvala, M.V.; Bapat, A.R.; Hurlburt, W.W.; Kostek, B.; Gonder, D.S.; Mastroeni, R.A.; Frail, D.E.
Biochemical characterization of osteo-testicular protein tyrosine phosphatase and its functional significance in rat primary osteoblasts
Biochemistry
40
814-821
2001
Rattus norvegicus
brenda
Calera, M.R.; Vallega, G.; Pilch, P.F.
Dynamics of protein-tyrosine phosphatases in rat adipocytes
J. Biol. Chem.
275
6308-6312
2000
Rattus norvegicus
brenda
Seligman, J.; Zipser, Y.; Kosower, N.S.
Tyrosine phosphorylation, thiol status, and protein tyrosine phosphatase in rat epididymal spermatozoa
Biol. Reprod.
71
1009-1015
2004
Rattus norvegicus
brenda
Fukaya, Y.; Yamaguchi, M.
Characterization of protein tyrosine phosphatase activity in rat liver microsomes: suppressive effect of endogenous regucalcin in transgenic rats
Int. J. Mol. Med.
14
427-432
2004
Rattus norvegicus
brenda
Easton, J.B.; Royer, A.R.; Middlemas, D.S.
The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor
J. Neurochem.
97
834-845
2006
Rattus norvegicus
brenda
Santos, M.A.; Santos, S.M.; Matozo, H.C.; Portugal, R.V.; Iuliano, R.; Fusco, A.; Polikarpov, I.
Expression, purification, and characterization of rat protein tyrosine phosphatase eta catalytic domain
Protein Expr. Purif.
41
113-120
2005
Rattus norvegicus
brenda
Matozo, H.C.; Nascimento, A.S.; Santos, M.A.; Iuliano, R.; Fusco, A.; Polikarpov, I.
Crystallization and preliminary X-ray diffraction analysis of rat protein tyrosine phosphatase eta
Acta Crystallogr. Sect. F
62
923-925
2006
Rattus norvegicus
brenda
Noordman, Y.E.; Jansen, P.A.; Hendriks, W.J.
Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells
J. Mol. Signal.
1
2006
2006
Mus musculus, Rattus norvegicus
brenda
Braithwaite, S.P.; Xu, J.; Leung, J.; Urfer, R.; Nikolich, K.; Oksenberg, D.; Lombroso, P.J.; Shamloo, M.
Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia
Eur. J. Neurosci.
27
2444-2452
2008
Rattus norvegicus
brenda
Navarrete-Vazquez, G.; Paoli, P.; Leon-Rivera, I.; Villalobos-Molina, R.; Medina-Franco, J.L.; Ortiz-Andrade, R.; Estrada-Soto, S.; Camici, G.; Diaz-Coutino, D.; Gallardo-Ortiz, I.; Martinez-Mayorga, K.; Moreno-Diaz, H.
Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity
Bioorg. Med. Chem.
17
3332-3341
2009
Rattus norvegicus
brenda
Fukuda, S.; Ohta, T.; Sakata, S.; Morinaga, H.; Ito, M.; Nakagawa, Y.; Tanaka, M.; Matsushita, M.
Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551
Diabetes Obes. Metab.
12
299-306
2010
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Nakashima, S.; Arnold, S.A.; Mahoney, E.T.; Sithu, S.D.; Zhang, Y.P.; D'Souza, S.E.; Shields, C.B.; Hagg, T.
Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats
J. Neurosci.
28
7293-7303
2008
Rattus norvegicus
brenda
Motohashi, S.; Koizumi, K.; Honda, R.; Maruyama, A.; Palmer, H.E.; Mashima, K.
Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners
Cell. Immunol.
289
128-134
2014
Rattus norvegicus
brenda