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Literature summary for 3.1.3.48 extracted from

  • Motohashi, S.; Koizumi, K.; Honda, R.; Maruyama, A.; Palmer, H.E.; Mashima, K.
    Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners (2014), Cell. Immunol., 289, 128-134.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Rattus norvegicus
-
[a protein]-tyrosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein aggregation of the high-affinity IgE receptor FceRI induces the phosphorylation of PTP-PEST at Ser39, thus resulting in the suppression of enzyme activity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
basophilic leukemia cell
-
Rattus norvegicus
-
RBL-2H3 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[a protein]-tyrosine phosphate + H2O
-
Rattus norvegicus [a protein]-tyrosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase-PEST
-
Rattus norvegicus
PTP-PEST
-
Rattus norvegicus
PTPN12
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus PTP-PEST mRNA expression is significantly induced upon the high-affinity IgE receptor FceRI-crosslinking up

General Information

General Information Comment Organism
physiological function protein tyrosine phosphatase-PEST regulates mast cell-activating signals in protein tyrosine phosphatase activity-dependent and -independent manners Rattus norvegicus