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Literature summary for 3.1.3.48 extracted from

  • Zhang, Z.Y.
    Kinetic and mechanistic characterization of a mammalian protein-tyrosine phosphatase, PTP1 (1995), J. Biol. Chem., 270, 11199-11204.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
phosphate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.892
-
4-nitrophenyl phosphate pH 5.5 Rattus norvegicus
0.953
-
4-methylumbelliferyl phosphate pH 5.5 Rattus norvegicus
1.19
-
1-naphthyl phosphate pH 7.5 Rattus norvegicus
1.88
-
1-naphthyl phosphate pH 5.5 Rattus norvegicus
2.01
-
phosphotyrosine pH 5.5 Rattus norvegicus
2.04
-
Phenyl phosphate pH 5.5 Rattus norvegicus
2.41
-
4-methylumbelliferyl phosphate pH 7.5 Rattus norvegicus
5.05
-
4-nitrophenyl phosphate pH 7.5 Rattus norvegicus
18.3
-
Phenyl phosphate pH 7.5 Rattus norvegicus
21.7
-
phosphotyrosine pH 7.5 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol the PTPase family contains both cell surface transmembrane receptor forms and cytolasmic nonreceptor forms. The receptor forms generally have an extracellular domain, a single transmembrane region, and one or two cytoplasmic PTPase domains. The intracellular PTPases contain a single catalytic domain and various amino- or carboxy-terminal extensions including SH2-domains that may have targeting or regulatory functions. The catalytic domain is the only structural element with an amino acid sequence identical among all PTPases from bacteria to mammals Rattus norvegicus 5829
-
plasma membrane the PTPase family contains both cell surface transmembrane receptor forms and cytoplasmic nonreceptor forms. The receptor forms generally have an extracellular domain, a single transmembrane region, and one or two cytoplasmic PTPase domains. The intracellular PTPases contain a single catalytic domain and various amino- or carboxy-terminal extensions including SH2-domains that may have targeting or regulatory functions. The catalytic domain is the only structural element with an amino acid sequence identical among all PTPases from bacteria to mammals Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-naphthyl phosphate + H2O
-
Rattus norvegicus 1-naphthol + phosphate
-
?
4-methylumbelliferyl phosphate + H2O
-
Rattus norvegicus 4-methylumbelliferone + phosphate
-
?
4-nitrophenyl phosphate + H2O
-
Rattus norvegicus 4-nitrophenol + phosphate
-
?
additional information protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity Rattus norvegicus ?
-
?
phenyl phosphate + H2O
-
Rattus norvegicus phenol + phosphate
-
?
phosphotyrosine + H2O
-
Rattus norvegicus tyrosine + phosphate
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.34
-
1-naphthyl phosphate pH 7.5 Rattus norvegicus
5.32
-
1-naphthyl phosphate pH 5.5 Rattus norvegicus
10.1
-
4-methylumbelliferyl phosphate pH 7.5 Rattus norvegicus
11.6
-
4-nitrophenyl phosphate pH 7.5 Rattus norvegicus
11.8
-
Phenyl phosphate pH 7.5 Rattus norvegicus
13.1
-
phosphotyrosine pH 7.5 Rattus norvegicus
64.9
-
Phenyl phosphate pH 5.5 Rattus norvegicus
72.9
-
phosphotyrosine pH 5.5 Rattus norvegicus
75.3
-
4-nitrophenyl phosphate pH 5.5 Rattus norvegicus
79.9
-
4-methylumbelliferyl phosphate pH 5.5 Rattus norvegicus