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Literature summary for 3.1.3.48 extracted from

  • Navarrete-Vazquez, G.; Paoli, P.; Leon-Rivera, I.; Villalobos-Molina, R.; Medina-Franco, J.L.; Ortiz-Andrade, R.; Estrada-Soto, S.; Camici, G.; Diaz-Coutino, D.; Gallardo-Ortiz, I.; Martinez-Mayorga, K.; Moreno-Diaz, H.
    Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity (2009), Bioorg. Med. Chem., 17, 3332-3341.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-chloro-N-(6-ethoxy-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-chloro-N-(6-methoxy-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-chloro-N-(6-methyl-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-chloro-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-fluoro-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-methoxy-N-(6-methoxy-1,3-benzothiazol -2-yl)benzenesulfonamide
-
Rattus norvegicus
4-methoxy-N-(6-methyl-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-methoxy-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-methyl-N-(6-methyl-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-methyl-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
4-nitro-N-(6-nitro-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
benzenesulfonamide
-
Rattus norvegicus
additional information inhibitor docking studies with PTP-1B, overview Rattus norvegicus
N-(4-([(6-ethoxy-1,3-benzothiazol-2-yl)amino]sulfonyl)phenyl)acetamide
-
Rattus norvegicus
N-(4-([(6-methoxy-1,3-benzothiazol-2-yl)amino]sulfonyl)phenyl)acetamide
-
Rattus norvegicus
N-(4-([(6-methyl-1,3-benzothiazol-2-yl)amino]sulfonyl)phenyl)acetamide
-
Rattus norvegicus
N-(4-[[(6-nitro-1,3-benzothiazol-2-yl)amino]sulfonyl]-phenyl)acetamide
-
Rattus norvegicus
N-(6-chloro-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
Rattus norvegicus
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-methoxybenzenesulfonamide
-
Rattus norvegicus
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-methylbenzenesulfonamide
-
Rattus norvegicus
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-nitrobenzene sulfonamide linear mixed-type inhibition, shows in vivo antihyperglycemic activity Rattus norvegicus
N-(6-ethoxy-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
N-(6-fluoro-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
Rattus norvegicus
N-(6-methoxy-1,3-benzothiazol-2-yl)-4-methylbenzenesulfonamide
-
Rattus norvegicus
N-(6-methoxy-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
Rattus norvegicus
N-(6-methoxy-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus
N-(6-methyl-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide linear mixed-type inhibition, shows in vivo antihyperglycemic activity Rattus norvegicus
N-(6-methyl-1,3-benzothiazol-2-yl)benzenesulfonamide
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Wistar rats
-

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0071
-
N-(6-methyl-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
Rattus norvegicus
0.0204
-
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-nitrobenzene sulfonamide
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0195
-
-
Rattus norvegicus N-(6-methyl-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
0.0409
-
-
Rattus norvegicus N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-nitrobenzene sulfonamide