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Information on EC 2.7.11.12 - cGMP-dependent protein kinase and Organism(s) Mus musculus and UniProt Accession P0C605
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2.7.11.12 cGMP-dependent protein kinaseIUBMB Comments
CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates . The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase .
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Word Map
- 2.7.11.12
- cyclase
-
guanylyl
-
guanylate
-
camp-dependent
- phosphodiesterase
- endothelial
- artery
-
natriuretic
- pka
- cardiac
- nitroprusside
- 8-br-cgmp
-
contractile
- atrial
- phosphoprotein
-
myocytes
-
vasodilation
- 8-bromo-cgmp
-
l-name
-
no-induced
- sildenafil
-
vasorelaxation
-
l-type
-
cgmp-mediated
-
vasodilator-stimulated
-
patch-clamp
-
membrane-permeable
- snap
- vasp
-
cell-attached
- monophosphorothioate
- nonoate
-
cgmp-independent
- zaprinast
-
no-cgmp
-
iberiotoxin
-
atp-sensitive
-
1h-1,2,4oxadiazolo4,3-aquinoxalin-1-one
-
large-conductance
- s-nitroso-n-acetylpenicillamine
-
8-bromo-cyclic
-
cgmp-specific
- cak
- drug development
- 8-bromoguanosine
- rp-camps
-
cgmp-inhibited
-
nitrovasodilators
- medicine
- mypt1
- pharmacology
-
no-sensitive
-
oxide-cyclic
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
cgmp-dependent protein kinase, protein kinase g, cyclic gmp-dependent protein kinase, cgkii, pkg-i, cgmp kinase, prkg1, pkg ii, cgk ii, cgmp-dependent protein kinase i, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CGK
CGK 1 alpha
-
-
-
-
CGK 1 beta
-
-
-
-
cGK-II
cGKI
CGKI-alpha
-
-
-
-
cGKI-beta
-
-
-
-
cGKII
cGMP-dependent protein kinase
cGMP-dependent protein kinase I
cGMP-dependent protein kinase II
cGMP-dependent protein kinase type I
-
-
Foraging protein
-
-
-
-
protein kinase G
Type II cGMP-dependent protein kinase
CGK
-
-
-
-
cGKII
-
-
-
-
cGMP-dependent protein kinase
-
-
-
-
protein kinase G
-
-
-
-
Type II cGMP-dependent protein kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (cGMP-dependent)
CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates [3]. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4].
CAS REGISTRY NUMBER
COMMENTARY
141588-27-4
-
141588-27-4
cGMP-dependent protein kinase
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + BAD protein
ADP + BAD phosphoprotein
-
phosphorylation on Ser155 by PKG I
-
-
?
ATP + cysteine-riche protein 2
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
i.e. CRP2, phosphorylation by cGKI and cGKII
-
-
?
ATP + EKRKRTYETF
ADP + phosphorylated EKRKRTYETF
-
p65-derived synthetic peptide substrate
-
-
?
ATP + glycogen synthase kinase-3beta
ADP + phosphorylated glycogen synthase kinase-3beta
-
-
-
?
ATP + GSK-3beta protein
ADP + GSK-3beta phosphoprotein
-
the enzyme phosphorylates GSK-3beta at serine-9 and inactivates it leading to the accumulation of beta-catenin and promoting the process of decidualization
-
-
?
ATP + Kemptide
ADP + phosphorylated Kemptide
-
i.e. LRRASLG
i.e. LRRA-phosphoserine-LG
-
?
ATP + MQLRRPSDRE
ADP + phosphorylated MQLRRPSDRE
-
p65-derived synthetic peptide substrate
-
-
?
ATP + NF-kappaB
ADP + phosphorylated NF-kappaB
-
recombinant human NF-kappaB p49 and p50 expressed in 293T cells
-
-
?
ATP + p65
ADP + phosphorylated p65
-
activity with recombinant wild-type p65 and mutants T305A and S276A
-
-
?
ATP + serine/threonine protein
ADP + serine/threonine phosphorylated protein
-
-
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
ATP + big potassium channel BKCa
ADP + phosphorylated big potassium channel BKCa
-
phosphorylation by cGKI leads to activation of the channel, a mechanism leading to Ca2+-dependent smooth muscle relaxation
-
-
?
ATP + big potassium channel BKCa
ADP + phosphorylated big potassium channel BKCa
-
phosphorylation by cGKI
-
-
?
ATP + FoxO1a
ADP + phosphorylated FoxO1a
-
interaction of enzyme with FocO1a is involved in regulation of myoblast cell fusion during myogenesis
-
-
?
ATP + FoxO1a
ADP + phosphorylated FoxO1a
-
enzyme expression is activated by FoxO1a which is then phosphorylated by cGKI for feedback inhibition of FoxO1a DNA binding, phosphorylation of Ser152-155 and Ser184, and weakly of Ser266 and Ser268
-
-
?
ATP + IRAG
ADP + phosphorylated IRAG
-
phosphorylation by cGKIbeta mediates the inhibition of inositol-1,4,5-trisphosphate-dependent Ca2+-release, one mechanism leading to smooth muscle relaxation, involved in platelet aggregation
-
-
?
ATP + IRAG
ADP + phosphorylated IRAG
-
i.e. inositol-1,4,5-trisphosphate-receptor-associated cGMP kinase substrate, phosphorylation by cGKIbeta
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
-
phosphorylation leads to stimulation of the sarcoendoplasmic reticulum pump Ca2+-ATPase, i.e. SERCA
-
-
?
ATP + Rho
ADP + phosphorylated rho
-
phosphorylation leads to inhibition of Rho
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
-
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
i.e. VASP, phosphorylation at Ser239 by cGKI
-
-
?
additional information
?
-
the cGMP/cGMP-dependent protein kinase I signaling pathway plays an important role in spinal nociceptive processing and interacts with cysteine-rich protein 2
-
-
?
additional information
?
-
-
cGK is a key enzyme in the nitric oxide-cGMP and natriuretic signalling cascades, it modulates smooth muscle relaxation, platelet aggregation, renin release, intestinal secretion, learning amd memory, cGKII is involved in androsterone homeostasis, pleiotropic effets of the enzyme on diverse tissues, overview
-
-
?
additional information
?
-
-
cGKI mediates NO signaling and plays a proatherogenic role in vascular smooth muscle cells, enzyme activation in primary smoothe muscle cells results in increased levels of proliferation and vascular cell adhesion molecule-1, peroxisome proliferato-activated receptor gamma, and phosphatidylinositol 3-kinase/Akt signaling, and in decreased plasminogen activator inhibitor 1 mRNA, overview
-
-
?
additional information
?
-
-
PKGII modulates mPer1 and mPer2 gene induction, not by phosphorylation of CREB at Ser133, and influences phase shifts of the circadian clock, regulation model, overview
-
-
?
additional information
?
-
-
sequential activation of p38 and ERK pathways by the enzyme leading to activation of the platelet integrin alphaIIb beta3
-
-
?
additional information
?
-
-
the enzyme mediates an exocytosis pathway via glycoprotein Ib-IX, and an aggregation-dependent platelet secretion pathway important for amplifying platelet activation, in stabilizing thrombi, and in arteriosclerosis and vascular remodeling, signaling mechanism activating the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation at serines 110, 114, 117, 126, and 445 and at Thr109 in vitro and in vivo
-
-
?
additional information
?
-
-
no activity with the cAMP-responsive element binding protein, i.e. CREB
-
-
?
additional information
?
-
-
cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview
-
-
?
additional information
?
-
-
PKG phosphorylates several substrates and interacts, by engaging its N-terminal, with numerous proteins
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + BAD protein
ADP + BAD phosphoprotein
-
phosphorylation on Ser155 by PKG I
-
-
?
ATP + big potassium channel BKCa
ADP + phosphorylated big potassium channel BKCa
-
phosphorylation by cGKI leads to activation of the channel, a mechanism leading to Ca2+-dependent smooth muscle relaxation
-
-
?
ATP + cysteine-riche protein 2
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
i.e. CRP2, phosphorylation by cGKI and cGKII
-
-
?
ATP + FoxO1a
ADP + phosphorylated FoxO1a
-
interaction of enzyme with FocO1a is involved in regulation of myoblast cell fusion during myogenesis
-
-
?
ATP + GSK-3beta protein
ADP + GSK-3beta phosphoprotein
-
the enzyme phosphorylates GSK-3beta at serine-9 and inactivates it leading to the accumulation of beta-catenin and promoting the process of decidualization
-
-
?
ATP + IRAG
ADP + phosphorylated IRAG
-
phosphorylation by cGKIbeta mediates the inhibition of inositol-1,4,5-trisphosphate-dependent Ca2+-release, one mechanism leading to smooth muscle relaxation, involved in platelet aggregation
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
-
phosphorylation leads to stimulation of the sarcoendoplasmic reticulum pump Ca2+-ATPase, i.e. SERCA
-
-
?
ATP + Rho
ADP + phosphorylated rho
-
phosphorylation leads to inhibition of Rho
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
-
-
-
?
additional information
?
-
the cGMP/cGMP-dependent protein kinase I signaling pathway plays an important role in spinal nociceptive processing and interacts with cysteine-rich protein 2
-
-
?
additional information
?
-
-
cGK is a key enzyme in the nitric oxide-cGMP and natriuretic signalling cascades, it modulates smooth muscle relaxation, platelet aggregation, renin release, intestinal secretion, learning amd memory, cGKII is involved in androsterone homeostasis, pleiotropic effets of the enzyme on diverse tissues, overview
-
-
?
additional information
?
-
-
cGKI mediates NO signaling and plays a proatherogenic role in vascular smooth muscle cells, enzyme activation in primary smoothe muscle cells results in increased levels of proliferation and vascular cell adhesion molecule-1, peroxisome proliferato-activated receptor gamma, and phosphatidylinositol 3-kinase/Akt signaling, and in decreased plasminogen activator inhibitor 1 mRNA, overview
-
-
?
additional information
?
-
-
PKGII modulates mPer1 and mPer2 gene induction, not by phosphorylation of CREB at Ser133, and influences phase shifts of the circadian clock, regulation model, overview
-
-
?
additional information
?
-
-
sequential activation of p38 and ERK pathways by the enzyme leading to activation of the platelet integrin alphaIIb beta3
-
-
?
additional information
?
-
-
the enzyme mediates an exocytosis pathway via glycoprotein Ib-IX, and an aggregation-dependent platelet secretion pathway important for amplifying platelet activation, in stabilizing thrombi, and in arteriosclerosis and vascular remodeling, signaling mechanism activating the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation at serines 110, 114, 117, 126, and 445 and at Thr109 in vitro and in vivo
-
-
?
additional information
?
-
-
cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview
-
-
?
additional information
?
-
-
PKG phosphorylates several substrates and interacts, by engaging its N-terminal, with numerous proteins
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
required for e.g. inhibition of inositol-1,4,5-trisphosphate-dependent Ca2+-release
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Rp-8-Br-pCPT-cGMPS
-
i.e. Rp-8-bromo-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate
KT5823
-
staurosporine analogue, inhibits in vitro by selective blockage of ATP binding
Rp-8-Br-PET-cGMPS
-
beta-phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphorothioate
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Bay412272
-
YC1 analogue, stimulates the enzyme in a NO-dependent manner, inhibition of phosphodiesterase 5
FoxO1a
-
directly activates enzyme expression binding to DNA in skeletal muscle
-
Sp-8-pCPT-PET-cGMPS
-
the compound significantly increases protein phosphorylation by 250%
-
YC1
-
i.e. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole, hem-dependent activation of cGK, inhibition of phosphodiesterase 5
cGMP
-
-
additional information
cGKI can be activated by natriuretic peptide receptor-B dependent cGMP production
-
additional information
-
cGKI can be activated by natriuretic peptide receptor-B dependent cGMP production
-
additional information
-
cGKII is upregulated by aldosterone inducation e.g. via low salt diet, NO induces cGMP production and thus increases enzyme activity, cGK is also activates via increased cGMP level by inhibition of the phosphodiesterase 5 by sildenafil, vardenafil, and taladafil, or by inhibition of Ca2+/calmodulin-specific cGMP-dependent phosphodiesterase 1
-
additional information
-
NO induces cGMP production and thus increases enzyme activity
-
additional information
-
NO, from NO donor sodium nitroprusside, induces cGMP production and thus increases enzyme activity
-
additional information
-
the enzyme mediates NO antiatherogenic and proatherogenic effects
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
-
distribution of cGKI isozymes in brain and eye, overview
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
when coexpressed with Rab11b wild type and S20V, cGK-II is predominantly localized to the plasma membrane
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
physiological function
additional information
-
the PKG-Ialpha isoform is more sensitive to ubiquitination compared with the PKG-Ibeta isoform
metabolism
-
molecular mechanisms governing the transcriptional and posttranscriptional regulation of PKG-I expression in vascular smooth muscle cells, overview
metabolism
-
requirement for NO/cGMP/PKG signaling downstream of 17beta-estradiol for prevention of etoposide-induced death of MLO-Y4 osteocyte-like cells. BAD phosphorylation on Ser136 and Ser155 by Akt and PKG I, respectively, regulate BAD interaction with Bcl-2. NO activates soluble guanylate cyclase, generating cGMP, which in turn regulates cGMP-dependent protein kinases and phosphodiesterases. Estradiol-induced Akt and ERK activation in osteocytes is mediated by NO/cGMP/PKG II, and Akt is necessary for the anti-apoptotic effect of estradiol
physiological function
-
cGMP-dependent protein kinase type I is an essential regulator of cellular function in blood vessels throughout the body
physiological function
-
PKG II is necessary for BAD Ser136 phosphorylation by Akt, allowing direct phosphorylation of Ser155 by PKG Ialpha. PKGIalpha and PKGII are independently required for estradiol- and cGMP-mediated protection against apoptosis, role of NO/cGMP signaling in 17beta-estradiol regulation of osteocyte survival
physiological function
-
PKG-I is a serine/threonine-specific protein kinase that is activated by the NO/sGC/cGMP system. PKG-I is involved in many cell functions, such as relaxation, platelet aggregation, remodelling, hypertrophy, apoptosis, differentiation, neuronal plasticity, and erectile dysfunction
physiological function
the enzyme present in cardiac smooth muscle cells or activated cardiac myofibroblasts is an important regulator of cardiac fibrosis
physiological function
-
type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium
physiological function
-
the enzyme has potential functions during decidualization
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KGP1_MOUSE
671
0
76350
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
additional information
-
the PKG-Ialpha isoform is more sensitive to ubiquitination compared with the PKG-Ibeta isoform
phosphoprotein
-
the enzyme performs autophosphorylation at serines 110, 114, 117, 126, and 445 and at Thr109, phosphorylation at Ser110 and Ser97 of the recombinant enzyme expressed in Sf9 insect cells, phosphorylation site mapping
phosphoprotein
-
PKG-I isoforms undergo autophosphorylation, in response to sustained activation/autophosphorylation, PKG-I might becomes ubiquitinated and degraded
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
S79D
replacement of an autophosphorylated Ser79 of cGKIbeta with an aspartic acid results in a mutant kinase with constitutive kinase activity in vitro and in vivo. The cGKIbetaS79D mutant localized to the cytoplasm and is only a weak activator of CRE-dependent gene transcription
C43S
-
the mutant enzyme is less responsive to cGMP-induced activation with about 5fold reduced affinity for cGMP compared to the wild type enzyme
additional information
additional information
-
construction of PKGI knockout mutant mice, phenotype analysis, platelet secretion, platelet aggregation, and Ca2+ mobilization are affected
additional information
-
construction of tissue-specific cGK-knockout mice causing several dysfunction phenotypes, overview
additional information
-
PKG-I knockout mutant mice show no induction of p38 by thrombin
additional information
-
PKGII-deficient mice are defective in renal functiona regulation, and in resetting the circadian clock because light induction of mPer2 gene in the hypothalamus is strongly reduced in the early peroid of the night, whereas mPer1 gene induction is elevated
additional information
-
primary myoblast of enzyme-deficient mice mutants show excessive cell fusion
additional information
-
during ischemia and reperfusion in vivo, mice with a cardiac myocyte-restricted deletion of PKG I display a more pronounced interaction of TAB1 with p38MAPK and a stronger phosphorylation of p38 MAPK in the myocardial area at risk during reperfusion and more apoptotic cardiac myocytes in the infarct border zone as compared to wild-type littermates
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination of isozyme PKGIalpha, functional co-expression of His-tagged enzyme in 293T cells with human NF-kappaB p49 and p50, NF-kappaB activates PKG, which increases 5fold transactivation activity of p65 from consensus sites but not from a nonconsensus NF-kappaB reporter
-
expression of His-tagged cGKII in Spodoptera frugiperda Sf9 cells using the baculovirus infection system
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
cGMP-dependent protein kinase activity is restored in vascular smooth muscle cells by transfection of primary mouse aortic smooth muscle cells with an expression vector coding for the catalytic domain of bovine PKG
-
cGMP-dependent protein kinase is downregulated in vessels from diabetic animals or in vascular smooth muscle cells exposed to high-glucose conditions
-
down-regulation of PKG-Ialpha protein occurs after chronic activation in murine aortic smooth muscle cells by the cGMP analogue in normoxic conditions
-
the enzyme has a gradually increased expression pattern during peri-implantation and artificial decidualization, and the enzyme expression is induced by estrogen and progesterone in the ovariectomized mouse uteri and primary cultured uterine stromal cells
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
additional information
-
data obtained with Rp-8-Br-PET-cGMPS as cGKI inhibitor should be interpreted with caution and not be used as sole evidence to dissect the role of cGKI in signaling processes
medicine
cGKII deficiency leads to dwarfism in mice as consequence of an elongated growth plate and impaired chondrocyte hypertrophy
medicine
-
all-D-YGRKKRRQRRRPPLRKKKKKH may help our understanding of how blood vessels constrict and dilate and may also aid the development of new strategies and therapeutic agents targeted to the prevention and treatment of vascular disorders
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Uhler, M.D.
Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain
J. Biol. Chem.
268
13586-13591
1993
Mus musculus (Q61410), Mus musculus
Collins, S.P.; Uhler, M.D.
Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription
J. Biol. Chem.
274
8391-8404
1999
Mus musculus (P0C605)
Li, Z.; Zhang, G.; Feil, R.; Han, J.; Du, X.
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3
Blood
107
965-972
2006
Homo sapiens, Mus musculus
Oster, H.; Werner, C.; Magnone, M.C.; Mayser, H.; Feil, R.; Seeliger, M.W.; Hofmann, F.; Albrecht, U.
cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock
Curr. Biol.
13
725-733
2003
Mus musculus
Schlossmann, J.; Hofmann, F.
cGMP-dependent protein kinases in drug discovery
Drug Discov. Today
10
627-634
2005
Homo sapiens, Mus musculus, Rattus norvegicus
He, B.; Weber, G.F.
Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation
Eur. J. Biochem.
270
2174-2185
2003
Bos taurus, Mus musculus
Koeppen, M.; Feil, R.; Siegl, D.; Feil, S.; Hofmann, F.; Pohl, U.; de Wit, C.
cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
Hypertension
44
952-955
2004
Mus musculus
Vaandrager, A.B.; Hogema, B.M.; Edixhoven, M.; van den Burg, C.M.; Bot, A.G.; Klatt, P.; Ruth, P.; Hofmann, F.; Van Damme, J.; Vandekerckhove, J.; de Jonge, H.R.
Autophosphorylation of cGMP-dependent protein kinase type II
J. Biol. Chem.
278
28651-28658
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Li, Z.; Zhang, G.; Marjanovic, J.A.; Ruan, C.; Du, X.
A platelet secretion pathway mediated by cGMP-dependent protein kinase
J. Biol. Chem.
279
42469-42475
2004
Homo sapiens, Mus musculus
Bois, P.R.; Brochard, V.F.; Salin-Cantegrel, A.V.; Cleveland, J.L.; Grosveld, G.C.
FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion
Mol. Cell. Biol.
25
7645-7656
2005
Mus musculus
Feil, S.; Zimmermann, P.; Knorn, A.; Brummer, S.; Schlossmann, J.; Hofmann, F.; Feil, R.
Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina
Neuroscience
135
863-868
2005
Mus musculus
Wolfsgruber, W.; Feil, S.; Brummer, S.; Kuppinger, O.; Hofmann, F.; Feil, R.
A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells
Proc. Natl. Acad. Sci. USA
100
13519-13524
2003
Mus musculus
Fiedler, B.; Feil, R.; Hofmann, F.; Willenbockel, C.; Drexler, H.; Smolenski, A.; Lohmann, S.M.; Wollert, K.C.
cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes
J. Biol. Chem.
281
32831-32840
2006
Mus musculus, Mus musculus C57BL/6, Rattus norvegicus
Yuasa, K.; Yamagami, S.; Nagahama, M.; Tsuji, A.
Trafficking of cGMP-dependent protein kinase II via interaction with Rab11
Biochem. Biophys. Res. Commun.
374
522-526
2008
Mus musculus
Kawasaki, Y.; Kugimiya, F.; Chikuda, H.; Kamekura, S.; Ikeda, T.; Kawamura, N.; Saito, T.; Shinoda, Y.; Higashikawa, A.; Yano, F.; Ogasawara, T.; Ogata, N.; Hoshi, K.; Hofmann, F.; Woodgett, J.R.; Nakamura, K.; Chung, U.I.; Kawaguchi, H.
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
J. Clin. Invest.
118
2506-2515
2008
Mus musculus (Q61410), Mus musculus
Schmidtko, A.; Gao, W.; Sausbier, M.; Rauhmeier, I.; Sausbier, U.; Niederberger, E.; Scholich, K.; Huber, A.; Neuhuber, W.; Allescher, H.D.; Hofmann, F.; Tegeder, I.; Ruth, P.; Geisslinger, G.
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain
J. Neurosci.
28
1320-1330
2008
Mus musculus (P0C605)
Schmidtko, A.; Gao, W.; Koenig, P.; Heine, S.; Motterlini, R.; Ruth, P.; Schlossmann, J.; Koesling, D.; Niederberger, E.; Tegeder, I.; Friebe, A.; Geisslinger, G.
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I
J. Neurosci.
28
8568-8576
2008
Mus musculus (P0C605), Mus musculus
Wang, S.; Li, Y.
Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation
Am. J. Physiol. Heart Circ. Physiol.
297
H2075-H2083
2009
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Nickl, C.K.; Raidas, S.K.; Zhao, H.; Sausbier, M.; Ruth, P.; Tegge, W.; Brayden, J.E.; Dostmann, W.R.
(D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha
Biochim. Biophys. Acta
1804
524-532
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Valtcheva, N.; Nestorov, P.; Beck, A.; Russwurm, M.; Hillenbrand, M.; Weinmeister, P.; Feil, R.
The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells
J. Biol. Chem.
284
556-562
2009
Bos taurus, Mus musculus
Sellak, H.; Choi, C.S.; Dey, N.B.; Lincoln, T.M.
Transcriptional and post-transcriptional regulation of cGMP-dependent protein kinase (PKG-I): pathophysiological significance
Cardiovasc. Res.
97
200-207
2013
Bos taurus, Oryctolagus cuniculus, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Lee, J.H.; Li, S.; Liu, T.; Hsu, S.; Kim, C.; Woods, V.L.; Casteel, D.E.
The amino terminus of cGMP-dependent protein kinase Ibeta increases the dynamics of the proteins cGMP-binding pockets
Int. J. Mass Spectrom.
302
44-52
2011
Mus musculus
Leiss, V.; Illison, J.; Domes, K.; Hofmann, F.; Lukowski, R.
Expression of cGMP-dependent protein kinase type I in mature white adipocytes
Biochem. Biophys. Res. Commun.
452
151-156
2014
Mus musculus
Wang, R.; Kwon, I.K.; Singh, N.; Islam, B.; Liu, K.; Sridhar, S.; Hofmann, F.; Browning, D.D.
Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium
Cell Death Differ.
21
427-437
2014
Mus musculus
Vallur, R.; Kalbacher, H.; Feil, R.
Catalytic activity of cGMP-dependent protein kinase type I in intact cells is independent of N-terminal autophosphorylation
PLoS ONE
9
e98946
2014
Mus musculus
Patrucco, E.; Domes, K.; Sbroggio, M.; Blaich, A.; Schlossmann, J.; Desch, M.; Rybalkin, S.D.; Beavo, J.A.; Lukowski, R.; Hofmann, F.
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis
Proc. Natl. Acad. Sci. USA
111
12925-12929
2014
Mus musculus (Q8I719), Mus musculus
Zhang, Y.; Yan, L.; Liu, J.; Cui, S.; Qiu, J.
cGMP-dependent protein kinase II determines beta-catenin accumulation that is essential for uterine decidualization in mice
Am. J. Physiol. Cell Physiol.
317
C1115-C1127
2019
Mus musculus
Kalyanaraman, H.; Zhuang, S.; Pilz, R.B.; Casteel, D.E.
The activity of cGMP-dependent protein kinase Ialpha is not directly regulated by oxidation-induced disulfide formation at cysteine 43
J. Biol. Chem.
292
8262-8268
2017
Mus musculus
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