Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cGMP | - |
Mus musculus | |
cGMP | - |
Bos taurus |
Application | Comment | Organism |
---|---|---|
additional information | data obtained with Rp-8-Br-PET-cGMPS as cGKI inhibitor should be interpreted with caution and not be used as sole evidence to dissect the role of cGKI in signaling processes | Mus musculus |
additional information | data obtained with Rp-8-Br-PET-cGMPS as cGKI inhibitor should be interpreted with caution and not be used as sole evidence to dissect the role of cGKI in signaling processes | Bos taurus |
Cloned (Comment) | Organism |
---|---|
cGKIalpha and cGKIbeta are cloned for expression in Sf9 insect cells | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KT5823 | - |
Bos taurus | |
KT5823 | - |
Mus musculus | |
Rp-8-Br-PET-cGMPS | beta-phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphorothioate | Bos taurus | |
Rp-8-Br-PET-cGMPS | beta-phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphorothioate | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Mus musculus | - |
ADP + a phosphoprotein | - |
? | |
ATP + a protein | Bos taurus | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by affinity chromatography | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Mus musculus | - |
vascular smooth muscle cell | VSMC | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Mus musculus | ADP + a phosphoprotein | - |
? | |
ATP + a protein | - |
Bos taurus | ADP + a phosphoprotein | - |
? | |
ATP + GRTGRRNSI-amide | assay substrate | Bos taurus | ADP + phosphorylated GRTGRRNSI-amide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGKI | isoforms alpha and beta | Mus musculus |
cGKI | isoforms alpha and beta | Bos taurus |
cGMP-dependent protein kinase type I | - |
Mus musculus |
cGMP-dependent protein kinase type I | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
activity assay | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00003 | - |
Rp-8-Br-PET-cGMPS | cGKI alpha | Bos taurus | |
0.00005 | - |
Rp-8-Br-PET-cGMPS | cGKI beta | Bos taurus |