Cloned (Comment) | Organism |
---|---|
DNA sequence determination of isozyme PKGIalpha, functional co-expression of His-tagged enzyme in 293T cells with human NF-kappaB p49 and p50, NF-kappaB activates PKG, which increases 5fold transactivation activity of p65 from consensus sites but not from a nonconsensus NF-kappaB reporter | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Rp-8-pCPT-cGMPS | - |
Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
isozyme PKGIalpha | - |
Mus musculus | - |
BALB/c mice, isozyme PKGIalpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | native purified from lung or recombinant | Bos taurus | - |
kidney | - |
Mus musculus | - |
lung | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + EKRKRTYETF | p65-derived synthetic peptide substrate | Mus musculus | ADP + phosphorylated EKRKRTYETF | - |
? | |
ATP + Kemptide | i.e. LRRASLG | Mus musculus | ADP + phosphorylated Kemptide | i.e. LRRA-phosphoserine-LG | ? | |
ATP + Kemptide | i.e. LRRASLG | Bos taurus | ADP + phosphorylated Kemptide | i.e. LRRA-phosphoserine-LG | ? | |
ATP + MQLRRPSDRE | p65-derived synthetic peptide substrate | Mus musculus | ADP + phosphorylated MQLRRPSDRE | - |
? | |
ATP + NF-kappaB | recombinant human NF-kappaB p49 and p50 expressed in 293T cells | Mus musculus | ADP + phosphorylated NF-kappaB | - |
? | |
ATP + NF-kappaB | recombinant human NF-kappaB p49 and p50 expressed in 293T cells | Bos taurus | ADP + phosphorylated NF-kappaB | - |
? | |
ATP + p65 | activity with recombinant wild-type p65 and mutants T305A and S276A | Mus musculus | ADP + phosphorylated p65 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cyclic GMP-dependent kinase | - |
Mus musculus |
cyclic GMP-dependent kinase | - |
Bos taurus |
PKG | - |
Mus musculus |
PKG | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Mus musculus |
22 | - |
assay at room temperature | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.9 | - |
assay at, substrate Kemptide | Mus musculus |
6.9 | - |
assay at, substrate Kemptide | Bos taurus |
7.5 | - |
assay at, substrate NF-kappaB | Mus musculus |
7.5 | - |
assay at, substrate NF-kappaB | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Bos taurus |