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Literature summary for 2.7.11.12 extracted from

  • Collins, S.P.; Uhler, M.D.
    Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription (1999), J. Biol. Chem., 274, 8391-8404.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
S79D replacement of an autophosphorylated Ser79 of cGKIbeta with an aspartic acid results in a mutant kinase with constitutive kinase activity in vitro and in vivo. The cGKIbetaS79D mutant localized to the cytoplasm and is only a weak activator of CRE-dependent gene transcription Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P0C605
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein autophosphorylation Mus musculus ADP + phosphoprotein
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?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase 1, beta isozyme
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
cGMP dependent on Mus musculus