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Literature summary for 2.7.11.12 extracted from

  • Li, Z.; Zhang, G.; Feil, R.; Han, J.; Du, X.
    Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3 (2006), Blood, 107, 965-972.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cGMP
-
 Homo sapiens
8-pCPT-GMP
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information PKG-I knockout mutant mice show no induction of p38 by thrombin Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
KT5823
-
 Homo sapiens
additional information PKG-I inhibition leads to abolished induction of p38 by thrombin Homo sapiens
Rp-8-Br-PET-cGMPS PKG-I inhibition leads to abolished induction of p38 by thrombin Homo sapiens
Rp-pCPT-cGMPS
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus sequential activation of p38 and ERK pathways by the enzyme leading to activation of the platelet integrin alphaIIb beta3 ?
-
 ?
additional information Homo sapiens sequential activation of p38 and ERK pathways by the enzyme leading to activation of the platelet integrin alphaIIb beta3 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Mus musculus
-
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information sequential activation of p38 and ERK pathways by the enzyme leading to activation of the platelet integrin alphaIIb beta3 Mus musculus ?
-
 ?
additional information sequential activation of p38 and ERK pathways by the enzyme leading to activation of the platelet integrin alphaIIb beta3 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKG
-
 Mus musculus
PKG
-
 Homo sapiens