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Literature summary for 2.7.11.12 extracted from

  • Lee, J.H.; Li, S.; Liu, T.; Hsu, S.; Kim, C.; Woods, V.L.; Casteel, D.E.
    The amino terminus of cGMP-dependent protein kinase Ibeta increases the dynamics of the proteins cGMP-binding pockets (2011), Int. J. Mass Spectrom., 302, 44-52.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PKG Ialpha and Ibeta are largely cytosolic enzymes Mus musculus 5829
-
membrane isozyme PKG II Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + BAD protein Mus musculus phosphorylation on Ser155 by PKG I ADP + BAD phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
gene prkg1, encoding isozyme PKG I in two splice variants, PKG Ialpha and Ibeta, and gene prkg2 encoding isozyme PKG II
-

Source Tissue

Source Tissue Comment Organism Textmining
MC-3T3 cell
-
Mus musculus
-
MLO-Y4 cell osteocyte-like cells Mus musculus
-
osteoblast primary Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + BAD protein phosphorylation on Ser155 by PKG I Mus musculus ADP + BAD phosphoprotein
-
?

Synonyms

Synonyms Comment Organism
PKG
-
Mus musculus
PKG I
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus silencing of PKG I or PKG II by siRNA targeting down

General Information

General Information Comment Organism
metabolism requirement for NO/cGMP/PKG signaling downstream of 17beta-estradiol for prevention of etoposide-induced death of MLO-Y4 osteocyte-like cells. BAD phosphorylation on Ser136 and Ser155 by Akt and PKG I, respectively, regulate BAD interaction with Bcl-2. NO activates soluble guanylate cyclase, generating cGMP, which in turn regulates cGMP-dependent protein kinases and phosphodiesterases. Estradiol-induced Akt and ERK activation in osteocytes is mediated by NO/cGMP/PKG II, and Akt is necessary for the anti-apoptotic effect of estradiol Mus musculus
physiological function PKG II is necessary for BAD Ser136 phosphorylation by Akt, allowing direct phosphorylation of Ser155 by PKG Ialpha. PKGIalpha and PKGII are independently required for estradiol- and cGMP-mediated protection against apoptosis, role of NO/cGMP signaling in 17beta-estradiol regulation of osteocyte survival Mus musculus