Reference on EC 2.7.1.137 - phosphatidylinositol 3-kinase and Organism(s) Homo sapiens and UniProt Accession P48736
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vanhaesebroeck, B.; Welham, M.J.; Kotani, K.; Stein, R.; Warne, P.H.; Zvelebil, M.J.; Higashi, K.; Volinia, S.; Downward, J.; Waterfield, M.D.
P110delta, a novel phosphoinositide 3-kinase in leukocytes
Proc. Natl. Acad. Sci. USA
94
4330-4335
1997
Homo sapiens (O00329)
Arcaro, A.; Zvelebil, M.J.; Wallasch, C.; Ullrich, A.; Waterfield, M.D.; Domin, J.
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
Mol. Cell. Biol.
20
3817-3830
2000
Homo sapiens
Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.
Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity
J. Biol. Chem.
273
33082-33090
1998
Homo sapiens, Homo sapiens (O00750)
Axelsson, L.; Hellberg, C.; Melander, F.; Smith, D.; Zheng, L.; Andersson, T.
Clustering of b2-Integrins on Human Neutrophils Activates Dual Signaling Pathways to PtdIns 3-Kinase
Exp. Cell Res.
256
257-263
2000
Homo sapiens
Bavelloni, A.; Santi, S.; Sirri, A.; Riccio, M.; Faenza, I.; Zini, N.; Cecchi, S.; Ferri, A.; Auron, P.; Maraldi, N.M.; Marmiroli, S.
Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells
J. Cell Sci.
112
631-640
1999
Homo sapiens
-
Baynes, K.C.R.; Beeton, C.A.; Panayotou, G.; Stein, R.; Soos, M.; Hansen, T.; Simpson, H.; O'Rahilly, S.; Shepherd, P.R.; Whitehead, J.P.
Natural variants of human p85a phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity
Diabetologia
43
321-331
2000
Homo sapiens
Beckwith, M.; Fenton, R.G.; Katona, I.M.; Longo, D.L.
Phosphatidylinositol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human b-lymphoma cell line
Blood
87
202-210
1996
Homo sapiens
Blondeau, F.; Laporte, J.; Bodin, S.; Superti-Furga, G.; Payrastre, B.; Mandel, J.L.
Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway
Hum. Mol. Genet.
9
2223-2229
2000
Homo sapiens, Rattus norvegicus
Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C.; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
J. Biol. Chem.
272
19236-19241
1997
Homo sapiens, Homo sapiens (O00329), Mus musculus, Mus musculus (O35940)
Dadi, H.; Ke, S.; Roifman, C.M.
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity
Blood
84
1579-1586
1994
Homo sapiens
Domin, J.; Pages, F.; Volinia, S.; Rittenhouse, S.E.; Zvelebil, M.J.; Stein, R.C.; Waterfield, M.D.
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
Biochem. J.
326
139-147
1997
Homo sapiens
-
Hardy, S.; Langelier, Y.; Prentki, M.
Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects
Cancer Res.
60
6353-6358
2000
Homo sapiens
Hauert, A.B.; Martinelli, S.; Marone, C.; Niggli, V.
Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis
Int. J. Biochem. Cell Biol.
34
838-854
2002
Homo sapiens
Herrera-Velit, P.; Reiner, N.E.
Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes
J. Immunol.
156
1157-1165
1996
Homo sapiens
Knall, C.; Young, S.; Nick, J.A.; Buhl, A.M.; Worthen, G.S.; Johnson, G.L.
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils
J. Biol. Chem.
271
2832-2838
1996
Homo sapiens
Krymskaya, V.P.; Hoffman, R.; Eszterhas, A.; Kane, S.; Ciocca, V.; Panettieri, R.A., Jr.
EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells
Am. J. Physiol.
276
L246-L255
1999
Homo sapiens
Liang, J.; Chen, J.K.; Schreiber, S.L.; Clardy, J.
Crystal structure of PI3K SH3 domain at 2.0.ANG. resolution
J. Mol. Biol.
257
632-643
1996
Homo sapiens
Marshall, A.J.; Krahn, A.K.; Ma, K.; Duronio, V.; Hou, S.
TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor
Mol. Cell. Biol.
22
5479-5491
2002
Homo sapiens
Pellegatta, F.; Chierchia, S.L.; Zocchi, M.R.
Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils
J. Biol. Chem.
273
27768-27771
1998
Homo sapiens
Phillips, W.A.; St.Clair, F.; Munday, A.D.; Thomas, R.J.S.; Mitchell, C.A.
Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
Cancer
83
41-47
1998
Homo sapiens
Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P.
Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor
J. Biol. Chem.
275
10093-10098
2000
Homo sapiens
Stoyanov, B.; Volinia, S.; Hanck, T.; Rubio, I.; Loubtchenkov, M.; Malek, D.; Stoyanova, S.; Vanhaesebroeck, B.; Dhand, R.; et al.
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
Science
269
690-693
1995
Homo sapiens, Homo sapiens (P48736)
Volinia, S.; Dhand, R.; Vanhaesebroeck, B.; MacDougall, L.; Stein, R.; Zvelebil, M.J.; Domin, J.; Panaretou, C.; Waterfield, M.D.
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
EMBO J.
14
3339-3348
1995
Homo sapiens
Yu, Y.; Sato, J.D.
MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
J. Cell. Physiol.
178
235-246
1999
Homo sapiens
Zhou, J.H.; Broussard, S.R.; Strle, K.; Freund, G.G.; Johnson, R.W.; Dantzer, R.; Kelley, K.W.
IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase
J. Immunol.
167
4436-4442
2001
Homo sapiens
Zini, N.; Ognibene, A.; Bavelloni, A.; Santi, S.; Sabatelli, P.; Baldini, N.; Scotlandi, K.; Serra, M.; Maraldi, N.M.
Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells
Histochem. Cell Biol.
106
457-464
1996
Homo sapiens
Brown, R.A.; Ho, L.K.; Weber-Hall, S.J.; Shipley, J.M.; Fry, M.J.
Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K
Biochem. Biophys. Res. Commun.
233
537-544
1997
Homo sapiens (O00750), Homo sapiens
McWhirter, J.R.; Galasso, D.L.; Wang, J.Y.
A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins
Mol. Cell. Biol.
13
7587-7595
1993
Homo sapiens (P42338)
Rozycka, M.; Lu, Y.J.; Brown, R.A.; Lau, M.R.; Shipley, J.M.; Fry, M.J.
cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12
Genomics
54
569-574
1998
Homo sapiens (O75747)
Stirdivant, S.M.; Ahern, J.; Conroy, R.R.; Barnett, S.F.; Ledder, L.M.; Oliff, A.; Heimbrook, D.C.
Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase
Bioorg. Med. Chem.
5
65-74
1997
Homo sapiens (P42336)
Volinia, S.; Hiles, I.; Ormondroyd, E.; Nizetic, D.; Antonacci, R.; Rocchi, M.; Waterfield, M.D.
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene
Genomics
24
472-477
1994
Schizosaccharomyces pombe (O14356), Schizosaccharomyces pombe (Q9Y7K2), Homo sapiens (P42336), Homo sapiens
Srivastava, R.; Ratheesh, A.; Gude, R.K.; Rao, K.V.K.; Panda, D.; Subrahmanyam, G.
Resveratrol inhibits type II phosphatidylinositol 4-kinase: A key component in pathways of phosphoinositide turn over
Biochem. Pharmacol.
70
1048-1055
2005
Homo sapiens
Alaimo, P.J.; Knight, Z.A.; Shokat, K.M.
Targeting the gatekeeper residue in phosphoinositide 3-kinases
Bioorg. Med. Chem.
13
2825-2836
2005
Saccharomyces cerevisiae, Homo sapiens
Jones, D.R.; Paneda, C.; Villar, A.V.; Alonso, A.; Goni, F.M.; Butikofer, P.; Brodbeck, U.; Shepherd, P.R.; Varela-Nieto, I.
Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases
FEBS Lett.
579
59-65
2005
Homo sapiens
Anderson, K.E.; Jackson, S.P.
Class I phosphoinositide 3-kinases
Int. J. Biochem. Cell Biol.
35
1028-1033
2003
Homo sapiens, Mammalia
Curnock, A.P.; Ward, S.G.
Development and characterization of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling
J. Immunol. Methods
273
29-41
2003
Homo sapiens
Meier, T.I.; Cook, J.A.; Thomas, J.E.; Radding, J.A.; Horn, C.; Lingaraj, T.; Smith, M.C.
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms
Protein Expr. Purif.
35
218-224
2004
Homo sapiens
Zhang, X.; Mi, J.; Wetsel, W.C.; Davidson, C.; Xiong, X.; Chen, Q.; Ellinwood, E.H.; Lee, T.H.
PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity
Biochem. Biophys. Res. Commun.
340
1144-1150
2006
Homo sapiens, Rattus norvegicus
Johnson, E.E.; Overmeyer, J.H.; Gunning, W.T.; Maltese, W.A.
Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes
J. Cell Sci.
119
1219-1232
2006
Homo sapiens (Q8NEB9), Homo sapiens
Zeng, X.; Overmeyer, J.H.; Maltese, W.A.
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
J. Cell Sci.
119
259-270
2006
Homo sapiens
Howlett, K.F.; Sakamoto, K.; Yu, H.; Goodyear, L.J.; Hargreaves, M.
Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise
Metab. Clin. Exp.
55
1046-1052
2006
Homo sapiens
Vogt, P.K.; Kang, S.; Elsliger, M.A.; Gymnopoulos, M.
Cancer-specific mutations in phosphatidylinositol 3-kinase
Trends Biochem. Sci.
32
342-349
2007
Homo sapiens
Xing, C.; Zhu, B.; Liu, H.; Yao, H.; Zhang, L.
Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901
Acta Biochim. Biophys. Sin. (Shanghai)
40
194-201
2008
Homo sapiens
von Vietinghoff, S.; Choi, M.; Rolle, S.; Luft, F.C.; Kettritz, R.
Febrile temperatures control antineutrophil cytoplasmic autoantibody-induced neutrophil activation via inhibition of phosphatidylinositol 3-kinase/Akt
Arthritis Rheum.
56
3149-3158
2007
Homo sapiens
Liu, P.; Xu, B.; Li, J.; Lu, H.
LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway
Biochem. Biophys. Res. Commun.
377
187-190
2008
Homo sapiens
Tamburini, J.; Chapuis, N.; Bardet, V.; Park, S.; Sujobert, P.; Willems, L.; Ifrah, N.; Dreyfus, F.; Mayeux, P.; Lacombe, C.; Bouscary, D.
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways
Blood
111
379-382
2008
Homo sapiens
Terragni, J.; Graham, J.R.; Adams, K.W.; Schaffer, M.E.; Tullai, J.W.; Cooper, G.M.
Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors
BMC Cell Biol.
9
6
2008
Homo sapiens
Opel, D.; Westhoff, M.A.; Bender, A.; Braun, V.; Debatin, K.M.; Fulda, S.
Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis
Cancer Res.
68
6271-6280
2008
Homo sapiens
Schnell, C.R.; Stauffer, F.; Allegrini, P.R.; OReilly, T.; McSheehy, P.M.; Dartois, C.; Stumm, M.; Cozens, R.; Littlewood-Evans, A.; Garcia-Echeverria, C.; Maira, S.M.
Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
Cancer Res.
68
6598-6607
2008
Homo sapiens
Kawaguchi, W.; Itamochi, H.; Kigawa, J.; Kanamori, Y.; Oishi, T.; Shimada, M.; Sato, S.; Shimogai, R.; Sato, S.; Terakawa, N.
Simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma
Cancer Sci.
98
2002-2008
2007
Homo sapiens
Qureshi, H.Y.; Ahmad, R.; Sylvester, J.; Zafarullah, M.
Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes
Cell. Signal.
19
1643-1651
2007
Homo sapiens
Sabnis, G.; Goloubeva, O.; Jelovac, D.; Schayowitz, A.; Brodie, A.
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens
Clin. Cancer Res.
13
2751-2757
2007
Homo sapiens
Uchida, M.; Iwase, M.; Takaoka, S.; Yoshiba, S.; Kondo, G.; Watanabe, H.; Ohashi, M.; Nagumo, M.; Shintani, S.
Enhanced susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in oral squamous cell carcinoma cells treated with phosphatidylinositol 3-kinase inhibitors
Int. J. Oncol.
30
1163-1171
2007
Homo sapiens
Iwase, M.; Yoshiba, S.; Uchid, M.; Takaoka, S.; Kurihara, Y.; Ito, D.; Hatori, M.; Shintani, S.
Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors
Int. J. Oncol.
31
1141-1147
2007
Homo sapiens
Pan, M.H.; Lin, C.C.; Lin, J.K.; Chen, W.J.
Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling
J. Agric. Food Chem.
55
5030-5037
2007
Homo sapiens
Tsoyi, K.; Park, H.B.; Kim, Y.M.; Chung, J.I.; Shin, S.C.; Lee, W.S.; Seo, H.G.; Lee, J.H.; Chang, K.C.; Kim, H.J.
Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway
J. Agric. Food Chem.
56
8969-8974
2008
Homo sapiens
Tzatsos, A.; Tsichlis, P.N.
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794
J. Biol. Chem.
282
18069-18082
2007
Homo sapiens
Havasi, A.; Li, Z.; Wang, Z.; Martin, J.L.; Botla, V.; Ruchalski, K.; Schwartz, J.H.; Borkan, S.C.
Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism
J. Biol. Chem.
283
12305-12313
2008
Homo sapiens
Lindemann, M.J.; Hu, Z.; Benczik, M.; Liu, K.D.; Gaffen, S.L.
Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
J. Biol. Chem.
283
14100-14108
2008
Homo sapiens
Mostefai, H.A.; Agouni, A.; Carusio, N.; Mastronardi, M.L.; Heymes, C.; Henrion, D.; Andriantsitohaina, R.; Martinez, M.C.
Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells
J. Immunol.
180
5028-5035
2008
Homo sapiens
Popa-Nita, O.; Rollet-Labelle, E.; Thibault, N.; Gilbert, C.; Bourgoin, S.G.; Naccache, P.H.
Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase
J. Leukoc. Biol.
82
763-773
2007
Homo sapiens
Ren, M.; Guan, Q.; Zhong, X.; Gong, B.; Sun, Y.; Xin, W.; Guo, J.; Wang, H.; Gao, L.; Zhao, J.
Phosphatidylinositol 3-kinase/nuclear factor-kappaB signaling pathway is involved in the regulation of IGF-I on Fas-associated death domain-like interleukin-1-converting enzyme-inhibitory protein expression in cultured FRTL thyroid cells
J. Mol. Endocrinol.
38
619-625
2007
Homo sapiens
Ito, K.; Caramori, G.; Adcock, I.M.
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
J. Pharmacol. Exp. Ther.
321
1-8
2007
Homo sapiens
Howes, A.L.; Chiang, G.G.; Lang, E.S.; Ho, C.B.; Powis, G.; Vuori, K.; Abraham, R.T.
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
Mol. Cancer Ther.
6
2505-2514
2007
Homo sapiens
Maira, S.M.; Stauffer, F.; Brueggen, J.; Furet, P.; Schnell, C.; Fritsch, C.; Brachmann, S.; Chene, P.; De Pover, A.; Schoemaker, K.; Fabbro, D.; Gabriel, D.; Simonen, M.; Murphy, L.; Finan, P.; Sellers, W.; Garcia-Echeverria, C.
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Mol. Cancer Ther.
7
1851-1863
2008
Homo sapiens
Shen, J.; Jiang, J.; Wei, Y.; Zhou, L.; Liu, D.; Zhou, J.; Gu, J.
Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis
Mol. Cell. Biochem.
304
361-367
2007
Homo sapiens
Wang, X.; Yue, P.; Chan, C.B.; Ye, K.; Ueda, T.; Watanabe-Fukunaga, R.; Fukunaga, R.; Fu, H.; Khuri, F.R.; Sun, S.Y.
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation
Mol. Cell. Biol.
27
7405-7413
2007
Homo sapiens
Xie, P.; Williams, D.S.; Atilla-Gokcumen, G.E.; Milk, L.; Xiao, M.; Smalley, K.S.; Herlyn, M.; Meggers, E.; Marmorstein, R.
Structure-based design of an Organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity
ACS Chem. Biol.
3
305-316
2008
Homo sapiens
Mitchell, C.; Kabolizadeh, P.; Ryan, J.; Roberts, J.D.; Yacoub, A.; Curiel, D.T.; Fisher, P.B.; Hagan, M.P.; Farrell, N.P.; Grant, S.; Dent, P.
Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling
Mol. Pharmacol.
72
704-714
2007
Homo sapiens
Ding, Y.; Choi, K.J.; Kim, J.H.; Han, X.; Piao, Y.; Jeong, J.H.; Choe, W.; Kang, I.; Ha, J.; Forman, H.J.; Lee, J.; Yoon, K.S.; Kim, S.S.
Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation
Am. J. Pathol.
172
1529-1541
2008
Homo sapiens
Liu, H.; Li, H.; Guo, L.; Li, M.; Li, C.; Wang, S.; Jiang, W.; Liu, X.; McNutt, M.A.; Li, G.
Mechanisms involved in phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes
Biochem. Pharmacol.
79
516-523
2010
Homo sapiens
Batra-Safferling, R.; Granzin, J.; Moedder, S.; Hoffmann, S.; Willbold, D.
Structural studies of the phosphatidylinositol 3-kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding
Biol. Chem.
391
33-42
2009
Homo sapiens
Wu, J.; Ding, W.G.; Matsuura, H.; Tsuji, K.; Zang, W.J.; Horie, M.
Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel
Br. J. Pharmacol.
156
377-387
2009
Homo sapiens
Sarveswaran, S.; Myers, C.E.; Ghosh, J.
MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: Synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase
Cancer Lett.
291
167-176
2009
Homo sapiens
Eichhorn, P.J.; Gili, M.; Scaltriti, M.; Serra, V.; Guzman, M.; Nijkamp, W.; Beijersbergen, R.L.; Valero, V.; Seoane, J.; Bernards, R.; Baselga, J.
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
Cancer Res.
68
9221-9230
2008
Homo sapiens
Baryawno, N.; Sveinbjoernsson, B.; Eksborg, S.; Chen, C.S.; Kogner, P.; Johnsen, J.I.
Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth
Cancer Res.
70
266-276
2010
Homo sapiens
Zhao, L.; Vogt, P.K.
Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (PI3K): Differential interactions with the regulatory subunit p85 and with RAS
Cell Cycle
9
596-600
2010
Homo sapiens
Montenegro, D.E.; Franklin, T.; Moscinski, L.C.; Zuckerman, K.S.; Hu, X.T.
TGFbeta inhibits GM-CSF-induced phosphorylation of ERK and MEK in human myeloid leukaemia cell lines via inhibition of phosphatidylinositol 3-kinase (PI3-k)
Cell Prolif.
42
1-9
2009
Homo sapiens
Kang, M.H.; Kim, J.S.; Seo, J.E.; Oh, S.C.; Yoo, Y.A.
BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway
Exp. Cell Res.
316
24-37
2010
Homo sapiens
Rivard, N.
Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function
Front. Biosci.
14
510-522
2009
Canis lupus familiaris, Homo sapiens
Kinoshita, H.; Matsuda, N.; Kaba, H.; Hatakeyama, N.; Azma, T.; Nakahata, K.; Kuroda, Y.; Tange, K.; Iranami, H.; Hatano, Y.
Roles of phosphatidylinositol 3-kinase-Akt and NADPH oxidase in adenosine 5-triphosphate-sensitive K+ channel function impaired by high glucose in the human artery
Hypertension
52
507-513
2008
Homo sapiens
Wang, J.; Rajput, A.; Kan, J.L.; Rose, R.; Liu, X.Q.; Kuropatwinski, K.; Hauser, J.; Beko, A.; Dominquez, I.; Sharratt, E.A.; Brattain, L.; Levea, C.; Sun, F.L.; Keane, D.M.; Gibson, N.W.; Brattain, M.G.
Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma
J. Biol. Chem.
284
10912-10922
2009
Homo sapiens
Scholl, S.; Bondeva, T.; Liu, Y.; Clement, J.H.; Hoeffken, K.; Wetzker, R.
Additive effects of PI3-kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of phosphatidylinositol 3-kinase gamma
J. Cancer Res. Clin. Oncol.
134
861-872
2008
Homo sapiens
McLaughlin, N.J.; Banerjee, A.; Khan, S.Y.; Lieber, J.L.; Kelher, M.R.; Gamboni-Robertson, F.; Sheppard, F.R.; Moore, E.E.; Mierau, G.W.; Elzi, D.J.; Silliman, C.C.
Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils
J. Immunol.
180
8192-8203
2008
Homo sapiens
Lau, C.; Wang, X.; Song, L.; North, M.; Wiehler, S.; Proud, D.; Chow, C.W.
Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization
J. Immunol.
180
870-880
2008
Homo sapiens
Ayral-Kaloustian, S.; Gu, J.; Lucas, J.; Cinque, M.; Gaydos, C.; Zask, A.; Chaudhary, I.; Wang, J.; Di, L.; Young, M.; Ruppen, M.; Mansour, T.S.; Gibbons, J.J.; Yu, K.
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates
J. Med. Chem.
53
452-459
2009
Homo sapiens, Mus musculus
Pereira, R.I.; Leitner, J.W.; Erickson, C.; Draznin, B.
Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3-kinase
Life Sci.
83
638-643
2008
Homo sapiens, Mus musculus
Itakura, E.; Kishi, C.; Inoue, K.; Mizushima, N.
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
Mol. Biol. Cell
19
5360-5372
2008
Homo sapiens, Homo sapiens (Q6ZNE5), Homo sapiens (Q9P2Y5)
Fernandes, A.F.; Bian, Q.; Jiang, J.K.; Thomas, C.J.; Taylor, A.; Pereira, P.; Shang, F.
Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells
Mol. Biol. Cell
20
3690-3699
2009
Homo sapiens
Hu, J.; Xia, X.; Cheng, A.; Wang, G.; Luo, X.; Reed, M.F.; Fojo, T.; Oetting, A.; Gong, J.; Yen, P.M.
A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy
Mol. Cancer Ther.
7
3719-3728
2008
Homo sapiens
Akashi, T.; Yamori, T.
Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS
Proteome Sci.
7
14
2009
Homo sapiens
Marwick, J.A.; Chung, K.F.; Adcock, I.M.
Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
Ther. Adv. Respir. Dis.
2009
1-16
2010
Homo sapiens
Chan, G.; Bivins-Smith, E.R.; Smith, M.S.; Yurochko, A.D.
NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes
Virus Res.
144
329-333
2009
Homo sapiens
Karam, M.; Lassarre, C.; Legay, C.; Ricort, J.M.
Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway
Biochim. Biophys. Acta
1823
558-569
2012
Homo sapiens
Zheng, W.; Gorre, N.; Shen, Y.; Noda, T.; Ogawa, W.; Lundin, E.; Liu, K.
Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
EMBO Rep.
11
890-895
2010
Homo sapiens (Q8NEB9)
Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
J. Biol. Chem.
285
10850-10861
2010
Homo sapiens, Mus musculus
Venkatareddy, M.; Verma, R.; Kalinowski, A.; Patel, S.R.; Shisheva, A.; Garg, P.
Distinct requirements for vacuolar protein sorting 34 downstream effector phosphatidylinositol 3-phosphate 5-kinase in podocytes versus proximal tubular cells
J. Am. Soc. Nephrol.
27
2702-2719
2016
Homo sapiens (Q8NEB9)
Mirzaa, G.M.; Conti, V.; Timms, A.E.; Smyser, C.D.; Ahmed, S.; Carter, M.; Barnett, S.; Hufnagel, R.B.; Goldstein, A.; Narumi-Kishimoto, Y.; Olds, C.; Collins, S.; Johnston, K.; Deleuze, J.F.; Nitschke, P.; Friend, K.; Harris, C.; Goetsch, A.; Martin, B.; Boyle, E.A.; Parrini, E.; Mei, D.; Tattini, L.; Slavotinek, A.; Blair, E.; Barnett, C.; Shendure, J.; Chelly, J.; Dobyns, W.B.; Guerrini, R.
Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study
Lancet Neurol.
14
1182-1195
2015
Homo sapiens (O00459), Homo sapiens
Burrows, N.; Williams, J.; Telfer, B.A.; Resch, J.; Valentine, H.R.; Fitzmaurice, R.J.; Eustace, A.; Irlam, J.; Rowling, E.J.; Hoang-Vu, C.; West, C.M.; Brabant, G.; Williams, K.J.
Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas
Oncotarget
7
63106-63123
2016
Homo sapiens
