Literature summary for 2.7.1.137 extracted from

Wang, J.; Rajput, A.; Kan, J.L.; Rose, R.; Liu, X.Q.; Kuropatwinski, K.; Hauser, J.; Beko, A.; Dominquez, I.; Sharratt, E.A.; Brattain, L.; Levea, C.; Sun, F.L.; Keane, D.M.; Gibson, N.W.; Brattain, M.G.
Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma (2009), J. Biol. Chem., 284, 10912-10922.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Ron kinase	Ron plays an essential role in maintaining malignant phenotypes of colon cancer cells through regulating mutant PI3K activity	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
H1047R	HCT-116 cells are heterozygous for gain of function mutant PIK3CA catalytic subunit	Homo sapiens
additional information	RNA interference-mediated knockdown of Ron kinase in a highly tumorigenic colon cancer HCT116 cell line leads to reduced proliferation as compared with the control cells and inhibits mutant phosphatidylinositol 3-kinase, phenotype, overview. Ron kinase knockout reduces metastasis in diverse human cancer cell lines, overview	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol	Homo sapiens	-	ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic cancer cell	-	Homo sapiens	-
HCT-116 cell	HCT-116 cells are heterozygous for gain of function mutant PIK3CA H1047R	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol	-	Homo sapiens	ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate	-	?

Subunits

Subunits	Comment	Organism
heterodimer	the regulatory p85 subunit of PI3K stabilizes catalytic subunit p110, but also inhibits its lipid kinase activity	Homo sapiens

Synonyms

Synonyms	Comment	Organism
PI3K	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at room temperature	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)