Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Wortmannin | PI3K-C2a is refractory to | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | essential divalent cation in lipid kinase assays | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity | ? | - |
? | |
additional information | Homo sapiens PI3K-C2alpha | class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
enzyme form PI3K-C2a and PI3K-C2b | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | carcinoma-derived A431 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidylinositol | - |
Homo sapiens | ADP + phosphatidylinositol 3-phosphate | - |
? | |
ATP + 1-phosphatidylinositol | - |
Homo sapiens PI3K-C2alpha | ADP + phosphatidylinositol 3-phosphate | - |
? | |
additional information | class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity | Homo sapiens | ? | - |
? | |
additional information | class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity | Homo sapiens PI3K-C2alpha | ? | - |
? |