Literature summary for 2.7.1.137 extracted from

Iwase, M.; Yoshiba, S.; Uchid, M.; Takaoka, S.; Kurihara, Y.; Ito, D.; Hatori, M.; Shintani, S.
Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors (2007), Int. J. Oncol., 31, 1141-1147.

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Application

Application	Comment	Organism
medicine	inhibition of PI 3-K enhances the susceptibility of oral squamous cell carcinoma cells to anticancer drug-mediated apoptosis through regulation of expression and post-translational modification of both pro- and antiapoptotic proteins. These findings could potentially lead to new strategies for improving the efficacy of anticancer drugs in oral squamous cell carcinoma cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
LY294002	inhibition of PI 3-K enhances the susceptibility of oral squamous cell carcinoma cells to anticancer drug-mediated apoptosis through regulation of expression and post-translational modification of both pro- and antiapoptotic proteins	Homo sapiens
Wortmannin	inhibition of PI 3-K enhances the susceptibility of oral squamous cell carcinoma cells to anticancer drug-mediated apoptosis through regulation of expression and post-translational modification of both pro- and antiapoptotic proteins	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HSC-2 cell	-	Homo sapiens	-
oral squamous cell carcinoma cell line	HSC-2	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PI 3-K	-	Homo sapiens

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Release 2023.1 (January 2023)