Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidylinositol | Homo sapiens | hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network | ADP + phosphatidylinositol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NEB9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
U-251 cell | glioblastoma cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidylinositol | - |
Homo sapiens | ADP + phosphatidylinositol 3-phosphate | - |
? | |
ATP + 1-phosphatidylinositol | hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network | Homo sapiens | ADP + phosphatidylinositol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hVps34 | - |
Homo sapiens |
type III phosphatidylinositol 3-kinase | - |
Homo sapiens |