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Literature summary for 2.7.1.137 extracted from

  • Baynes, K.C.R.; Beeton, C.A.; Panayotou, G.; Stein, R.; Soos, M.; Hansen, T.; Simpson, H.; O'Rahilly, S.; Shepherd, P.R.; Whitehead, J.P.
    Natural variants of human p85a phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity (2000), Diabetologia, 43, 321-331.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information the Arg409Gln p85a subunit of a natural variant is associated with lower insulin-stimulated phosphoinositide 3-kinase activity compared with wild-type, 15% reduction. The recruitment of Arg409Gln p85a into phosphotyrosine complexes is not significantly impaired. The impaired phosphoinositide 3-kinase activity of the Arg409Gln mutant suggests that it could contribute to the insulin resistance seen in this family. The Met326Ile p85a variant appears to have no functional effect on the insulin-stimulated phosphoinositide 3-kinase activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens plays a central part in the mediation of insulin-stimulated glucose disposal ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?
additional information plays a central part in the mediation of insulin-stimulated glucose disposal Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
p85a phosphoinositide 3-kinase
-
 Homo sapiens