Cloned (Comment) | Organism |
---|---|
genotyping | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | identification of hot-spot mutations in gene PIK2CA encoding the catalytic subunit p110alpha of PI3K, gain-of-function mutations allowing the mutant enzyme to constitutvely activate AKT signaling and induce oncogenic transformation in vitro and in vivo, the mutations lead to exchanges in the helical and kinase domains, overview. The gain of function induced by helical domain mutations require RAS-Gtp binding, while the kinase domain mutation is active in absence of RAS-Gtp binding, but depends on the interaction with p85, moleculr mechanisms, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene PIK3CA encoding the catalytic subunit p110alpha of PI3K | - |
Synonyms | Comment | Organism |
---|---|---|
PI3K | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | gene PIK3CA, encoding the catalytic subunit p110alpha of PI3K, is mutated in about 12% of all human cancers, as single point mutations of hot-spot mutation with exchange of three positions, overview | Homo sapiens |
physiological function | the enzyme activates Akt signaling | Homo sapiens |