Information on EC 1.2.3.1 - aldehyde oxidase

for references in articles please use BRENDA:EC1.2.3.1
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.2.3.1
-
RECOMMENDED NAME
GeneOntology No.
aldehyde oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aldehyde + H2O + O2 = a carboxylate + H2O2
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Valine, leucine and isoleucine degradation
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Tyrosine metabolism
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Tryptophan metabolism
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Vitamin B6 metabolism
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Nicotinate and nicotinamide metabolism
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Retinol metabolism
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Drug metabolism - cytochrome P450
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Metabolic pathways
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
aldehyde:oxygen oxidoreductase
Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6]. The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase) [5,7].
CAS REGISTRY NUMBER
COMMENTARY hide
9029-07-6
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9033-52-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
navel orangeworm
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Nistari strain
UniProt
Manually annotated by BRENDA team
Nistari strain
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
house mosquito, organophosphorus insecticide-resistant strain PelRR, aldehyde oxidase may play a role in insecticide resistance
SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain DSM 12254, aminolytic strain performing thiosulfate dismutation
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Manually annotated by BRENDA team
ATCC 27774
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Manually annotated by BRENDA team
lacks FAD
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
DBA/2 mouse
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Manually annotated by BRENDA team
no activity in Aspergillus nidulans
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Hass avocado
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
KY 4690
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Manually annotated by BRENDA team
12695
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Manually annotated by BRENDA team
strain ATCC10970, enzyme belongs to xanthine oxidase family
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Manually annotated by BRENDA team
strain ATCC10970, enzyme belongs to xanthine oxidase family
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
B0LAZ9, B0LB00, B0LB01
aldehyde oxidase catalyzes the final step in the synthesis of abscisic acid and possibly of indole-3-acetic acid; aldehyde oxidase catalyzes the final step in the synthesis of abscisic acid and possibly of indole-3-acetic acid; aldehyde oxidase catalyzes the final step in the synthesis of abscisic acid and possibly of indole-3-acetic acid; aldehyde oxidase catalyzes the final step in the synthesis of abscisic acid and possibly of indole-3-acetic acid
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
show the reaction diagram
-
i.e. (S)-RS-8359
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?
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
?
show the reaction diagram
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i.e. (S)-RS-8359
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?
(+)-biotin (+)-sulfoxide methyl ester + acetaldehyde + H2O
?
show the reaction diagram
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under anaerobic conditions
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?
(+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
show the reaction diagram
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i.e. RS-8359
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?
(1S)-camphor oxime + H2O + 2-hydroxypyrimidine
(1S)-camphor + (1S)-camphor imine + NH3
show the reaction diagram
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
(2E)-hex-2-enal + H2O + O2
(2E)-hex-2-enoic acid + H2O2
show the reaction diagram
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-
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?
(2E)-non-2-enal + H2O + O2
(2E)-non-2-enoic acid + H2O2
show the reaction diagram
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?
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
show the reaction diagram
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i.e. S-8359
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?
(S)-RS-8359
?
show the reaction diagram
(S)-RS-8359 + H2O + O2
2-keto-(S)-RS-8359 + H2O2
show the reaction diagram
(Z)-11-hexadecenal + H2O + O2
(Z)-11-hexadecenoic acid + H2O2
show the reaction diagram
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?
(Z)-7-dodecenal + H2O + O2
(Z)-7-dodecenoic acid + H2O2
show the reaction diagram
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?
(Z)-7-tetradecenal + H2O + O2
(Z)-7-tetradecenoic acid + H2O2
show the reaction diagram
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?
(Z)-9-hexadecenal + H2O + O2
(Z)-9-hexadecenoic acid + H2O2
show the reaction diagram
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?
(Z)-9-tetradecenal + H2O + O2
(Z)-9-tetradecenoic acid + H2O2
show the reaction diagram
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?
1-methoxy-2-naphthaldehyde + H2O + O2
1-methoxy-2-naphthoic acid + H2O2
show the reaction diagram
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?
1-methyl-acetylpyridine + H2O + ferricyanide
?
show the reaction diagram
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?
1-naphthaldehyde + H2O + O2
1-naphthalene carboxylic acid + H2O2
show the reaction diagram
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?
1-naphthaldehyde + H2O + O2
1-naphthoic acid + H2O2
show the reaction diagram
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?
1-nitropyrene + H2O + O2
?
show the reaction diagram
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?
13-cis-retinal + O2 + H2O
13-cis-retinoate + H2O2
show the reaction diagram
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?
2,3-diazanaphthalene + O2
1-phthalazinone
show the reaction diagram
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?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
show the reaction diagram
2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide + H2O + O2
?
show the reaction diagram
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i.e. c-met inhibitor capmatinib
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?
2-hydroxybenzaldehyde + H2O + O2
2-hydroxybenzoate + H2O2
show the reaction diagram
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?
2-hydroxypyrimidine + ferricyanide
?
show the reaction diagram
2-hydroxypyrimidine + H2O + ferricyanide + O2
?
show the reaction diagram
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?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
show the reaction diagram
2-hydroxypyrimidine + O2 + H2O
?
show the reaction diagram
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?
2-hydroxypyrimidine + O2 + H2O
? + H2O2
show the reaction diagram
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?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
show the reaction diagram
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?
2-methylbenzaldehyde + H2O + O2
2-methylbenzoate + H2O2
show the reaction diagram
2-naphthaldehyde + H2O + O2
2-naphthoic acid + H2O2
show the reaction diagram
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?
2-pyrimidone + H2O + O2
? + H2O2
show the reaction diagram
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?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
show the reaction diagram
3,4-dihydroxybenzaldehyde + H2O + O2
3,4-dihydroxybenzoate + H2O2
show the reaction diagram
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38.2% of the rate with benzaldehyde
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?
3,4-dimethoxybenzaldehyde + H2O + O2
3,4-dimethoxybenzoate + H2O2
show the reaction diagram
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?
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-oxide + electron donor
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine + an electron acceptor
show the reaction diagram
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electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
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?
3-aminocarbonyl-1-methylpyridinium chloride + H2O + O2
?
show the reaction diagram
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?
3-hydroxybenzaldehyde + H2O + O2
3-hydroxybenzoate + H2O2
show the reaction diagram
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?
3-hydroxypropionaldehyde + H2O + O2
3-hydroxypropionate + H2O2
show the reaction diagram
3-methoxy-2-naphthaldehyde + H2O + O2
3-methoxy-2-naphthoic acid + H2O2
show the reaction diagram
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?
3-methoxy-4-hydroxybenzaldehyde + H2O + O2
3-methoxy-4-hydroxybenzoate + H2O2
show the reaction diagram
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?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
show the reaction diagram
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?
3-methylbenzaldehyde + H2O + O2
3-methylbenzoate + H2O2
show the reaction diagram
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
show the reaction diagram
4-(dimethylamino)-cinnamaldehyde + H2O + O2
?
show the reaction diagram
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?
4-(dimethylamino)cinnamaldehyde + H2O + O2
?
show the reaction diagram
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?
4-(dimethylamino)cinnamaldehyde + nitrite + H2O + O2
? + nitric oxide
show the reaction diagram
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide
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?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
show the reaction diagram
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
show the reaction diagram
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?
4-hydroxyl-2-nonenal + H2O + O2
4-hydroxy-2-nonenoate + H2O2
show the reaction diagram
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?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
show the reaction diagram
4-hydroxypyrimidine + H2O + O2
?
show the reaction diagram
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ferricyanide as electron acceptor under aerobic conditions
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?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
show the reaction diagram
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?
4-methylbenzaldehyde + H2O + O2
4-methylbenzoate + H2O2
show the reaction diagram
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoic acid + H2O2
show the reaction diagram
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-
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?
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine + H2O + O2
?
show the reaction diagram
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i.e. brimonidine
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?
5-fluoropyrimidine + H2O + O2
5-fluorouracil + H2O2
show the reaction diagram
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?
6-benzylguanine + H2O + O2
?
show the reaction diagram
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?
6-chloroquinazolin-4(3H)-one + H2O + O2
6-chloroquinazoline-2,4(1H,3H)-dione + H2O2
show the reaction diagram
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?
6-deoxypenciclovir
penciclovir
show the reaction diagram
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is catalyzed by AOX1
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?
6-deoxypenciclovir + H2O + O2
?
show the reaction diagram
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?
6-dimethyloamino-2-naphthaldehyde + H2O + O2
6-dimethylamino-2-naphthoic acid + H2O2
show the reaction diagram
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?
6-ethyl-5H-dibenz(c,e)azepine + H2O + O2
?
show the reaction diagram
-
2,6-dichlorophenol-indophenol as electron acceptor
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?
6-mercaptopurine + H2O + O2
?
show the reaction diagram
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?
6-methoxy-2-naphthaldehyde + H2O + O2
6-methoxy-2-naphthoic acid + H2O2
show the reaction diagram
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?
6-methoxyquinazolin-4(3H)-one + H2O + O2
6-methoxyquinazoline-2,4(1H,3H)-dione + H2O2
show the reaction diagram
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?
6-methylpurine + H2O + chromate
?
show the reaction diagram
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?
6-methylquinazolin-4(3H)-one + H2O + O2
6-methylquinazoline-2,4(1H,3H)-dione + H2O2
show the reaction diagram
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-
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?
6-methylthiopurine + H2O + O2
6-methylthio-8-hydroxypurine + H2O2
show the reaction diagram
-
2,6-dichlorophenol indophenol can also act as electron acceptor
-
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?
6-thioxanthine + H2O + O2
6-thiouric acid + H2O2
show the reaction diagram
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-
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?
7-methoxy-1-naphthaldehyde + H2O + O2
7-methoxy-2-naphthoic acid + H2O2
show the reaction diagram
-
-
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?
9-cis-retinal + O2 + H2O
9-cis-retinoate + H2O2
show the reaction diagram
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-
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?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
show the reaction diagram
abscisic aldehyde + O2 + H2O
abscisic acid + H2O2
show the reaction diagram
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-
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?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
show the reaction diagram
acetaldehyde + H2O + O2
acetate + H2O2
show the reaction diagram
acetaldehyde + H2O + O2
acetic acid + H2O2
show the reaction diagram
acetaldehyde + O2 + H2O
acetate + H2O2
show the reaction diagram
acetamiprid + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
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?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
show the reaction diagram
acrolein + H2O + O2
?
show the reaction diagram
results indicate that AtraAOX2 also functions as a xenobiotic-degrading enzyme
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
show the reaction diagram
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
show the reaction diagram
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
show the reaction diagram
allopurinol + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
?
anthracene-9-carboxaldehyde + H2O + O2
anthracene-9-carboxylate + H2O2
show the reaction diagram
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
show the reaction diagram
benzaldehyde + 2,6-dichlorophenol indophenol
?
show the reaction diagram
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
benzaldehyde + H2O + 2,6-dichlorophenolindophenol
benzoate + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
show the reaction diagram
benzaldehyde + H2O + O2
benzoic acid + H2O2
show the reaction diagram
benzaldehyde + O2 + H2O
benzoate + H2O2
show the reaction diagram
benzamidoxime + H2O + 2-hydroxypyrimidine
benzamidine + ?
show the reaction diagram
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
-
-
?
BIBX1382 + H2O + O2
BIBU1476 + ?
show the reaction diagram
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
bombykal + H2O + O2
?
show the reaction diagram
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
show the reaction diagram
butanal + H2O + O2
butyric acid + H2O2
show the reaction diagram
butylaldehyde + H2O + O2
butanoate + H2O2
show the reaction diagram
butyraldehyde + H2O + O2
butanoate + H2O2
show the reaction diagram
-
-
-
-
?
carbazeran + H2O + O2
?
show the reaction diagram
-
-
-
-
?
carbazeran + H2O + O2
carbazeran phthalazinone + ?
show the reaction diagram
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
chloroacetaldehyde + H2O + O2
chloroacetic acid + H2O2
show the reaction diagram
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
cinchonidine + H2O + O2
?
show the reaction diagram
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
show the reaction diagram
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
show the reaction diagram
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
show the reaction diagram
clothianidin + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (2E)-2-[([(2-chloro-1,3-thiazol-5-yl)methyl]amino)(methylamino)methylene]-1-hydroxy-1-oxodiazanium, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
clothianidin + NMNH
nitroso-clothianidin + amino-clothianidin + ?
show the reaction diagram
-
-
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
show the reaction diagram
-
32% of activity with n-hexylaldehyde
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
show the reaction diagram
decylaldehyde + H2O + O2
decanoate + H2O2
show the reaction diagram
desmethyl-thiamethoxam + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
dibenzyl sulfoxide + acetaldehyde + H2O
?
show the reaction diagram
-
under anaerobic conditions
-
-
?
dinotefuran + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. 1-methyl-2-nitro-3-(tetrahydrofuran-3-ylmethyl)guanidine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
diphenyl sulfoxide + acetaldehyde + H2O
?
show the reaction diagram
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
show the reaction diagram
DL-glyceraldehyde + O2 + H2O
glycerate + H2O2
show the reaction diagram
dodecyl aldehyde + H2O + O2
dodecanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
show the reaction diagram
formaldehyde + H2O + O2
formate + H2O2
show the reaction diagram
formaldehyde + H2O + O2
formic acid + H2O2
show the reaction diagram
formaldehyde + O2 + H2O
formate + H2O2
show the reaction diagram
formate + O2
CO2 + H2O2
show the reaction diagram
-
-
-
-
?
furfural + H2O + O2
2-furoic acid + H2O2
show the reaction diagram
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
glutaraldehyde + H2O + O2
? + H2O2
show the reaction diagram
-
-
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
show the reaction diagram
glutaraldehyde + O2 + H2O
glutarate + H2O2
show the reaction diagram
-
-
-
-
?
glyceraldehyde + H2O + O2
2,3-dihydroxypropanoic acid + H2O2
show the reaction diagram
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
glycoaldehyde + H2O + O2
hydroxyacetic acid + H2O2
show the reaction diagram
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
glycolaldehyde + H2O + O2
hydroxyacetic acid + H2O2
show the reaction diagram
-
-
-
-
?
glyoxal + H2O + O2
? + H2O2
show the reaction diagram
-
-
-
-
?
glyoxal + H2O + O2
glyoxylate + H2O2
show the reaction diagram
heptaldehyde + H2O + O2
heptanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
show the reaction diagram
heptylaldehyde + H2O + O2
heptanoate + H2O2
show the reaction diagram
hexanal + H2O + O2
hexanoic acid + H2O2
show the reaction diagram
hexylaldehyde + H2O + O2
hexanoate + H2O2
show the reaction diagram
hypoxanthine + O2 + H2O
xanthine + H2O2
show the reaction diagram
-
22-26% of the activity compared to purine
-
?
imidacloprid + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
imidacloprid + H2O + O2
nitroso-imidacloprid
show the reaction diagram
-
-
without addition of an electron donor, product is nitroso-imidacloprid
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
show the reaction diagram
imidacloprid + NMNH
nitroso-imidacloprid + amino-imidacloprid + ?
show the reaction diagram
-
-
-
-
?
imipramine N-oxide + electron donor
imipramine + electron acceptor
show the reaction diagram
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
show the reaction diagram
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
show the reaction diagram
indole 3-carbaldehyde + H2O + O2
indole 3-carboxylate + H2O2
show the reaction diagram
indole-3-aldehyde + H2O + O2
indole-3-carboxylate + H2O2
show the reaction diagram
indole-3-aldehyde + H2O + O2
indole-3-carboxylic acid + H2O2
show the reaction diagram
indole-3-aldehyde + O2 + H2O
indole-3-carboxylate + H2O2
show the reaction diagram
isobutyraldehyde + H2O + O2
isobutyric acid + H2O2
show the reaction diagram
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
isovaleraldehyde + H2O + O2
isovaleric acid + H2O2
show the reaction diagram
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
L-methionine sulfoxide + acetaldehyde + H2O
?
show the reaction diagram
-
under anaerobic conditions
-
-
?
m-tolualdehyde + H2O + O2
m-methylbenzoic acid + H2O2
show the reaction diagram
-
-
-
-
?
methotrexate + H2O + O2
7-hydroxymethotrexate + H2O2
show the reaction diagram
methotrexate + H2O + O2
?
show the reaction diagram
n-alkanal + H2O + O2
n-alkanoic acid + H2O2
show the reaction diagram
-
C5-C10, C12, C14 with decreasing activities
-
-
?
n-heptanal + H2O + O2
n-heptanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
n-heptylaldehyde + H2O + O2
heptanoate + H2O2
show the reaction diagram
-
78% of activity with n-hexylaldehyde
-
-
?
n-heptylaldehyde + O2 + H2O
heptanoate + H2O2
show the reaction diagram
-
-
-
-
?
n-hexanal + H2O + O2
n-hexanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
n-hexylaldehyde + H2O + O2
hexanoate + H2O2
show the reaction diagram
-
-
-
-
?
N-methyl-5,6-benzoquinolinium + H2O + ferricyanide
?
show the reaction diagram
-
-
-
-
?
N-methylimidacloprid + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (2E)-1-[(6-chloropyridin-3-yl)methyl]-3-methyl-N-nitroimidazolidin-2-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
N-methylnicotinamide + electron acceptor + H2O
?
show the reaction diagram
-
electron acceptors i.e.: dichlorophenolindophenol, nitro blue tetrazolium, ferricyanide, diaphorase activity
-
-
?
N-methylphenanthridinium + H2O + ferricyanide
N-methyl-6-phenanthridone + ferrocyanide
show the reaction diagram
-
-
-
-
?
N-methylphthalazinium + O2 + H2O
?
show the reaction diagram
-
-
-
-
?
N-methylquinolinium + H2O + electron donor
N-methyl-4-quinolone and N-methyl-2-quinolone + electron acceptor
show the reaction diagram
n-pentanal + H2O + O2
n-pentanoic acid + H2O2
show the reaction diagram
-
-
-
-
?
N-phenylquinolinium + H2O + electron donor
N-phenyl-4-quinolone and N-phenyl-2-quinolone + electron acceptor
show the reaction diagram
n-valeraldehyde + O2 + H2O
valerate + H2O2
show the reaction diagram
-
-
-
-
?
N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
?
show the reaction diagram
-
-
-
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
show the reaction diagram
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
DACA-9(10H)-acridone + ?
show the reaction diagram
-
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide i.e. DACA, an experimental antitumor agent
-
-
?
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide-9-(10H)-acridone + H2O2
show the reaction diagram
-
antitumor drug
-
-
?
N1-methyl-nicotineamide + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
?
N1-methylnicotinamide + 2,6-dichlorophenol indophenol
?
show the reaction diagram
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + ?
show the reaction diagram
-
variations in the ratio of the amount of pyridones to the total amount of NMN and pyridones in urine are closely related to the enzyme activity
-
-
-
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
show the reaction diagram
N1-propylnicotinamide + H2O + O2
N1-propyl-2-pyridone-5-carboxamide + N1-propyl-4-pyridone-3-carboxamide + H2O2
show the reaction diagram
NADH + nitrite + H2O + O2
? + nitric oxide
show the reaction diagram
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide. NADH reacts with aldehyde oxidase at the FAD site of the enzyme
-
-
?
nitenpyram + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (E)-N-[(6-chloropyridin-3-yl)methyl]-N-ethyl-N'-methyl-2-nitroethylene-1,1-diamine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, partial inactivation of neonicotinoid insecticide substrate
-
-
?
nitenpyram + NMNH
nitroso-nitenpyram + amino-nitenpyram + ?
show the reaction diagram
-
-
-
-
?
nithiazine + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (2Z)-2-(nitromethylene)-1,3-thiazinane, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, partial inactivation of neonicotinoid insecticide substrate
-
-
?
nonanal + H2O + O2
nonanoic acid + H2O2
show the reaction diagram
-
-
-
?
o-tolualdehyde + H2O + O2
o-methylbenzoic acid + H2O2
show the reaction diagram
-
-
-
-
?
O6-benzylguanine + H2O + O2
O6-benzyl-8-oxoguanine + ?
show the reaction diagram
octylaldehyde + H2O + O2
octanoate + H2O2
show the reaction diagram
octylaldehyde + O2 + H2O
octanoate + H2O2
show the reaction diagram
-
-
-
-
?
p-aminobenzamidine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
show the reaction diagram
p-dimethyl aminocinnamaldehyde + H2O + O2
? + H2O2
show the reaction diagram
-
-
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
show the reaction diagram
p-methoxybenzaldehyde + H2O + O2
p-methoxybenzoate + H2O2
show the reaction diagram
-
-
-
-
?
p-tolualdehyde + H2O + O2
p-methylbenzoic acid + H2O2
show the reaction diagram
-
-
-
-
?
PF-4217903 + H2O + O2
?
show the reaction diagram
-
-
-
-
?
PF-945863 + H2O + O2
?
show the reaction diagram
-
-
-
-
?
phenanthrene-9-carboxaldehyde + H2O + O2
phenanthrene-9-carboxylate + H2O2
show the reaction diagram
-
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
show the reaction diagram
phenanthridine + H2O + O2
6-phenantridone + H2O2
show the reaction diagram
phenanthridine + H2O + O2
?
show the reaction diagram
phenanthridine + H2O + O2
phenanthridinone + H2O2
show the reaction diagram
-
-
-
-
?
phenanthridine + O2 + H2O
?
show the reaction diagram
-
-
-
-
?
phenothiazine sulfoxide + acetaldehyde + H2O
?
show the reaction diagram
-
under anaerobic conditions
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetate + H2O2
show the reaction diagram
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
show the reaction diagram
phthalaldehyde + H2O + O2
phthalic acid + H2O2
show the reaction diagram
-
13% of activity with n-hexylaldehyde
-
-
?
phthalazine + 2,6-dichlorophenol indophenol
?
show the reaction diagram
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
phthalazine + ferricyanide
1-phthalazinone + ferrocyanide
show the reaction diagram
-
-
-
-
?
phthalazine + ferricyanide
?
show the reaction diagram
-
-
-
-
?
phthalazine + H2O + 2,6-dichlorophenol indophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
show the reaction diagram
phthalazine + H2O + O2
? + H2O2
show the reaction diagram
phthalazine + O2 + H2O
1-phthalazinone + H2O2
show the reaction diagram
propanal + H2O + O2
propanoic acid + H2O2
show the reaction diagram
highest AtraAOX2 activity
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
show the reaction diagram
propionaldehyde + H2O + O2
propionic acid + H2O2
show the reaction diagram
protocatechualdehyde + H2O + O2
protocatechuic acid + H2O2
show the reaction diagram
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
pteridine + H2O + O2
?
show the reaction diagram
-
-
-
-
-
purine + O2 + H2O
? + H2O2
show the reaction diagram
-
best substrate tested
-
?
purine derivative + H2O + ferricyanide
oxidized purine derivative + ?
show the reaction diagram
-
various purine derivatives are listed, this enzyme catalyzes usually a ring methine group vicinal to a ring nitrogen
-
-
?
pyrazolo[3,4-d]pyrimidine + H2O + ferricyanide
oxidized pyrazolo[3,4-d]pyrimidine + ?
show the reaction diagram
-
various pyrazolo[3,4-d]pyrimidines are listed, this enzyme catalyzes usually a ring methine group vicinal to a ring nitrogen
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
show the reaction diagram
quinazolin-4(3H)-one + H2O + O2
quinazoline-2,4(1H,3H)-dione + H2O2
show the reaction diagram
-
-
-
-
?
quinazoline + H2O + O2
?
show the reaction diagram
-
-
-
-
-
quinine + H2O + O2
?
show the reaction diagram
-
-
-
?
quinoline + H2O + electron donor
?
show the reaction diagram
retinal + O2 + H2O
retinoate + H2O2
show the reaction diagram
retinal + O2 + H2O
retinoic acid + H2O2
show the reaction diagram
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
show the reaction diagram
-
-
-
-
?
retinaldehyde + H2O + O2
retinoic acid + H2O2
show the reaction diagram
-
-
-
?
retinaldehyde + O2 + H2O
retinoic acid + H2O2
show the reaction diagram
-
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
show the reaction diagram
salicylaldoxime + H2O + 2-hydroxypyrimidine
salicylaldehyde + NH3 + ?
show the reaction diagram
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
terephthalaldehyde + H2O + O2
terephthalic acid + H2O2
show the reaction diagram
-
45% of activity with n-hexylaldehyde
-
-
?
thiacloprid + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. ((2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene)cyanamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
thiamethoxam + H2O + O2
? + H2O2
show the reaction diagram
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
tropylium tetrafluoroborate + H2O + ferricyanide
tropone + ?
show the reaction diagram
-
other electron acceptors as dichloroindophenol and chromate
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
show the reaction diagram
valeraldehyde + H2O + O2
valeric acid + H2O2
show the reaction diagram
vanillin + H2O + O2
vanillic acid + H2O2
show the reaction diagram
vanillin + O2 + H2O
vanillic acid + H2O2
show the reaction diagram
veratraldehyde + H2O + O2
veratranoate + H2O2
show the reaction diagram
veratraldehyde + H2O + O2
veratric acid + H2O2
show the reaction diagram
-
18% of activity with n-hexylaldehyde
-
-
?
xanthine + H2O + O2
? + H2O2
show the reaction diagram
xanthine + O2 + H2O
urate + H2O2
show the reaction diagram
-
low activity
-
?
XK-469 + H2O + O2
3-oxo-XK-469 + ?
show the reaction diagram
-
hepatic clearance less than 4.3 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
XK-469 + H2O + O2
?
show the reaction diagram
-
-
-
-
?
Z11Z13-16Ald + H2O + O2
? + H2O2
show the reaction diagram
low AtraAOX2 activity
-
-
?
zaleplon + H2O + O2
5-oxozaleplon + ?
show the reaction diagram
-
hepatic clearance less than 4.3 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
zaleplon + H2O + O2
?
show the reaction diagram
-
-
-
-
?
zebularine + H2O + O2
uridine + H2O2
show the reaction diagram
zoniporide + H2O + O2
2-oxozoniporide + H2O2
show the reaction diagram
-
i.e. 1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl guanidine
-
-
?
zoniporide + H2O + O2
?
show the reaction diagram
-
-
-
-
?
zonisamide + H2O + O2
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
13-cis-retinal + O2 + H2O
13-cis-retinoate + H2O2
show the reaction diagram
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
show the reaction diagram
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
show the reaction diagram
9-cis-retinal + O2 + H2O
9-cis-retinoate + H2O2
show the reaction diagram
-
-
-
?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
show the reaction diagram
-
four aldehyde oxidases are known that have varying affinities to abscisic aldehyde. AOdelta, endcoded by AAO3 specifically catalyses this step in rosette leaves
-
-
?
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
show the reaction diagram
hypoxanthine + O2 + H2O
xanthine + H2O2
show the reaction diagram
-
22-26% of the activity compared to purine
-
?
purine + O2 + H2O
? + H2O2
show the reaction diagram
-
best substrate tested
-
?
retinal + O2 + H2O
retinoate + H2O2
show the reaction diagram
xanthine + O2 + H2O
urate + H2O2
show the reaction diagram
-
low activity
-
?
additional information
?
-