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(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
-
i.e. (S)-RS-8359
-
-
?
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
?
-
i.e. (S)-RS-8359
-
-
?
(+)-biotin (+)-sulfoxide methyl ester + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
(+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine + H2O + O2
?
-
i.e. RS-8359
-
-
?
(1S)-camphor oxime + H2O + 2-hydroxypyrimidine
(1S)-camphor + (1S)-camphor imine + NH3
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
(2E)-hex-2-enal + H2O + O2
(2E)-hex-2-enoic acid + H2O2
-
-
-
?
(2E)-non-2-enal + H2O + O2
(2E)-non-2-enoic acid + H2O2
-
-
-
?
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
-
i.e. S-8359
-
-
?
(S)-RS-8359 + H2O + O2
2-keto-(S)-RS-8359 + H2O2
(Z)-11-hexadecenal + H2O + O2
(Z)-11-hexadecenoic acid + H2O2
-
-
-
-
?
(Z)-7-dodecenal + H2O + O2
(Z)-7-dodecenoic acid + H2O2
-
-
-
-
?
(Z)-7-tetradecenal + H2O + O2
(Z)-7-tetradecenoic acid + H2O2
-
-
-
-
?
(Z)-9-hexadecenal + H2O + O2
(Z)-9-hexadecenoic acid + H2O2
-
-
-
-
?
(Z)-9-tetradecenal + H2O + O2
(Z)-9-tetradecenoic acid + H2O2
-
-
-
-
?
1-methoxy-2-naphthaldehyde + H2O + O2
1-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
1-methyl-acetylpyridine + H2O + ferricyanide
?
-
-
-
-
?
1-naphthaldehyde + H2O + O2
1-naphthalene carboxylic acid + H2O2
-
-
-
?
1-naphthaldehyde + H2O + O2
1-naphthoic acid + H2O2
-
-
-
-
?
1-nitropyrene + H2O + O2
?
-
-
-
?
13-cis-retinal + O2 + H2O
13-cis-retinoate + H2O2
-
-
-
?
2,3-diazanaphthalene + O2
1-phthalazinone
-
-
-
-
?
2,4-dihydroxybenzaldehyde + H2O + O2
2,4-dihydroxybenzoate + H2O2
-
-
-
?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide + H2O + O2
?
-
i.e. c-met inhibitor capmatinib
-
-
?
2-hydroxybenzaldehyde + H2O + O2
2-hydroxybenzoate + H2O2
-
-
-
-
?
2-hydroxypyrimidine + ferricyanide
?
2-hydroxypyrimidine + H2O + ferricyanide + O2
?
-
-
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
2-hydroxypyrimidine + O2 + H2O
?
-
-
-
-
?
2-hydroxypyrimidine + O2 + H2O
? + H2O2
-
-
-
?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
2-methyl-E-2-butenal + H2O + O2
2-methyl-E-2-butenoic acid + H2O2
-
-
-
?
2-methylbenzaldehyde + H2O + O2
2-methylbenzoate + H2O2
2-naphthaldehyde + H2O + O2
2-naphthoic acid + H2O2
-
-
-
-
?
2-pyrimidone + H2O + O2
? + H2O2
-
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
3,4-dihydroxybenzaldehyde + H2O + O2
3,4-dihydroxybenzoate + H2O2
-
38.2% of the rate with benzaldehyde
-
-
?
3,4-dimethoxybenzaldehyde + H2O + O2
3,4-dimethoxybenzoate + H2O2
-
-
-
-
?
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-oxide + electron donor
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine + an electron acceptor
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
-
-
?
3-aminocarbonyl-1-methylpyridinium chloride + H2O + O2
?
-
-
-
-
?
3-hydroxybenzaldehyde + H2O + O2
3-hydroxybenzoate + H2O2
-
-
-
-
?
3-hydroxypropionaldehyde + H2O + O2
3-hydroxypropionate + H2O2
3-methoxy-2-naphthaldehyde + H2O + O2
3-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
3-methoxy-4-hydroxybenzaldehyde + H2O + O2
3-methoxy-4-hydroxybenzoate + H2O2
-
-
-
-
?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
3-methylbenzaldehyde + H2O + O2
3-methylbenzoate + H2O2
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
4-(dimethylamino)-cinnamaldehyde + H2O + O2
?
-
-
-
-
?
4-(dimethylamino)cinnamaldehyde + H2O + O2
4-(dimethylamino)cinnamic acid + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + H2O + O2
?
-
-
-
-
?
4-(dimethylamino)cinnamaldehyde + nitrite + H2O + O2
? + nitric oxide
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
4-hydroxyl-2-nonenal + H2O + O2
4-hydroxy-2-nonenoate + H2O2
-
-
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
4-hydroxypyrimidine + H2O + O2
?
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
4-methylbenzaldehyde + H2O + O2
4-methylbenzoate + H2O2
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoate + H2O2
-
-
-
?
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoic acid + H2O2
-
-
-
-
?
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine + H2O + O2
?
-
i.e. brimonidine
-
-
?
5-fluoropyrimidine + H2O + O2
5-fluorouracil + H2O2
-
-
-
-
?
5-nitroquinoline + H2O + O2
2-oxo-5-nitroquinoline + 5-aminoquinoline + 2-oxo-5-aminoquinoline
-
-
-
?
6-benzylguanine + H2O + O2
?
-
-
-
-
?
6-chloroquinazolin-4(3H)-one + H2O + O2
6-chloroquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-deoxypenciclovir
penciclovir
-
is catalyzed by AOX1
-
-
?
6-deoxypenciclovir + H2O + O2
?
-
-
-
-
?
6-dimethyloamino-2-naphthaldehyde + H2O + O2
6-dimethylamino-2-naphthoic acid + H2O2
-
-
-
-
?
6-ethyl-5H-dibenz(c,e)azepine + H2O + O2
?
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
6-mercaptopurine + H2O + O2
?
-
-
-
-
?
6-methoxy-2-naphthaldehyde + H2O + O2
6-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
6-methoxyquinazolin-4(3H)-one + H2O + O2
6-methoxyquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-methylpurine + H2O + chromate
?
-
-
-
-
?
6-methylquinazolin-4(3H)-one + H2O + O2
6-methylquinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
6-methylthiopurine + H2O + O2
6-methylthio-8-hydroxypurine + H2O2
-
2,6-dichlorophenol indophenol can also act as electron acceptor
-
-
?
6-thioxanthine + H2O + O2
6-thiouric acid + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
7-methoxy-1-naphthaldehyde + H2O + O2
7-methoxy-2-naphthoic acid + H2O2
-
-
-
-
?
9-cis-retinal + O2 + H2O
9-cis-retinoate + H2O2
-
-
-
?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
abscisic aldehyde + O2 + H2O
abscisic acid + H2O2
-
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
acetaldehyde + H2O + O2
acetate + H2O2
acetaldehyde + H2O + O2
acetic acid + H2O2
acetaldehyde + O2 + H2O
acetate + H2O2
acetamiprid + H2O + O2
? + H2O2
-
i.e. (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
acrolein + H2O + O2
?
results indicate that AtraAOX2 also functions as a xenobiotic-degrading enzyme
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
aldicarb + H2O + O2
? + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
allopurinol + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
anthracene-9-carboxaldehyde + H2O + O2
anthracene-9-carboxylate + H2O2
-
-
-
-
?
azelnidipine + H2O + O2
? + H2O2
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
benzaldehyde + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
benzaldehyde + H2O + 2,6-dichlorophenolindophenol
benzoate + reduced 2,6-dichlorophenolindophenol
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
benzaldehyde + H2O + O2
benzoic acid + H2O2
benzaldehyde + O2 + H2O
benzoate + H2O2
benzamidoxime + H2O + 2-hydroxypyrimidine
benzamidine + ?
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
-
-
?
BIBX1382 + H2O + O2
BIBU1476 + ?
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
butanal + H2O + O2
butanoic acid + H2O2
butanal + H2O + O2
butyric acid + H2O2
butylaldehyde + H2O + O2
butanoate + H2O2
butyraldehyde + H2O + O2
butanoate + H2O2
carbazeran + H2O + O2
?
-
-
-
-
?
carbazeran + H2O + O2
? + H2O2
-
-
-
?
carbazeran + H2O + O2
carbazeran phthalazinone + ?
-
high hepatic clearance of 17 to 18 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
chloroacetaldehyde + H2O + O2
chloroacetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
cinchonidine + H2O + O2
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
clonazepam + H2O + O2
? + H2O2
-
-
-
?
clothianidin + H2O + O2
? + H2O2
-
i.e. (2E)-2-[([(2-chloro-1,3-thiazol-5-yl)methyl]amino)(methylamino)methylene]-1-hydroxy-1-oxodiazanium, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
clothianidin + NMNH
nitroso-clothianidin + amino-clothianidin + ?
-
-
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
crotonaldehyde + H2O + O2
crotonic acid + H2O2
decylaldehyde + H2O + O2
decanoate + H2O2
desmethyl-thiamethoxam + H2O + O2
? + H2O2
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
dibenzyl sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
dinotefuran + H2O + O2
? + H2O2
-
i.e. 1-methyl-2-nitro-3-(tetrahydrofuran-3-ylmethyl)guanidine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
diphenyl sulfoxide + 2,6-dichlorophenolindophenol
?
-
-
-
-
r
diphenyl sulfoxide + acetaldehyde + H2O
?
diphenyl sulfoxide + methylene blue
?
-
-
-
-
r
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
DL-glyceraldehyde + O2 + H2O
glycerate + H2O2
dodecyl aldehyde + H2O + O2
dodecanoic acid + H2O2
-
-
-
?
E,E-2,4-decadienal + 2 H2O + 2 O2
E,E-2,4-decadienoic acid + 2 H2O2
-
-
-
?
E-2-hexenal + H2O + O2
E-2-hexenoic acid + H2O2
-
-
-
?
E-2-octenal + H2O + O2
E-2-octenoic acid + H2O2
-
-
-
?
E-2-pentenal + H2O + O2
E-2-pentenoic acid + H2O2
-
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
ethyl vanillin + H2O + O2
ethyl vanillic acid + H2O2
-
-
-
?
famciclovir + H2O + O2
? + H2O2
-
-
-
?
flunitrazepam + H2O + O2
? + H2O2
-
-
-
?
flutamide + H2O + O2
? + H2O2
-
-
-
?
formaldehyde + H2O + O2
formate + H2O2
formaldehyde + H2O + O2
formic acid + H2O2
formaldehyde + O2 + H2O
formate + H2O2
furfural + H2O + O2
2-furoic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
glutaraldehyde + H2O + O2
? + H2O2
-
-
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
glutaraldehyde + O2 + H2O
glutarate + H2O2
-
-
-
-
?
glyceraldehyde + H2O + O2
2,3-dihydroxypropanoic acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
glycoaldehyde + H2O + O2
hydroxyacetic acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
glycolaldehyde + H2O + O2
hydroxyacetic acid + H2O2
-
-
-
-
?
glyoxal + H2O + O2
? + H2O2
-
-
-
-
?
glyoxal + H2O + O2
glyoxylate + H2O2
heptaldehyde + H2O + O2
heptanoic acid + H2O2
-
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
heptylaldehyde + H2O + O2
heptanoate + H2O2
hexanal + H2O + O2
hexanoic acid + H2O2
hexylaldehyde + H2O + O2
hexanoate + H2O2
hypoxanthine + O2 + H2O
xanthine + H2O2
-
22-26% of the activity compared to purine
-
?
imidacloprid + H2O + O2
? + H2O2
-
i.e. (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
imidacloprid + H2O + O2
nitroso-imidacloprid
-
-
without addition of an electron donor, product is nitroso-imidacloprid
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
imidacloprid + NMNH
nitroso-imidacloprid + amino-imidacloprid + ?
-
-
-
-
?
imipramine N-oxide + electron donor
imipramine + electron acceptor
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde under anaerobic conditions
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
indole 3-carbaldehyde + H2O + O2
indole 3-carboxylate + H2O2
indole-3-acetaldehyde + H2O + O2
indole-3-acetic acid + H2O2
-
-
-
?
indole-3-aldehyde + H2O + O2
indole-3-carboxylate + H2O2
indole-3-aldehyde + H2O + O2
indole-3-carboxylic acid + H2O2
indole-3-aldehyde + O2 + H2O
indole-3-carboxylate + H2O2
isobutyraldehyde + H2O + O2
isobutyric acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
isovaleraldehyde + H2O + O2
isovaleric acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
L-methionine sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
m-tolualdehyde + H2O + O2
m-methylbenzoic acid + H2O2
-
-
-
-
?
methotrexate + H2O + O2
7-hydroxymethotrexate + H2O2
methotrexate + H2O + O2
?
N-(2-(dimethylamino)ethyl)acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
?
n-alkanal + H2O + O2
n-alkanoic acid + H2O2
-
C5-C10, C12, C14 with decreasing activities
-
-
?
n-heptanal + H2O + O2
n-heptanoic acid + H2O2
-
-
-
-
?
n-heptylaldehyde + H2O + O2
heptanoate + H2O2
-
78% of activity with n-hexylaldehyde
-
-
?
n-heptylaldehyde + O2 + H2O
heptanoate + H2O2
-
-
-
-
?
n-hexanal + H2O + O2
n-hexanoic acid + H2O2
-
-
-
-
?
n-hexylaldehyde + H2O + O2
hexanoate + H2O2
-
-
-
-
?
N-methyl-5,6-benzoquinolinium + H2O + ferricyanide
?
-
-
-
-
?
N-methylimidacloprid + H2O + O2
? + H2O2
-
i.e. (2E)-1-[(6-chloropyridin-3-yl)methyl]-3-methyl-N-nitroimidazolidin-2-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
N-methylnicotinamide + electron acceptor + H2O
?
-
electron acceptors i.e.: dichlorophenolindophenol, nitro blue tetrazolium, ferricyanide, diaphorase activity
-
-
?
N-methylphenanthridinium + H2O + ferricyanide
N-methyl-6-phenanthridone + ferrocyanide
-
-
-
-
?
N-methylphthalazinium + O2 + H2O
?
-
-
-
-
?
N-methylquinolinium + H2O + electron donor
N-methyl-4-quinolone and N-methyl-2-quinolone + electron acceptor
n-pentanal + H2O + O2
n-pentanoic acid + H2O2
-
-
-
-
?
N-phenylquinolinium + H2O + electron donor
N-phenyl-4-quinolone and N-phenyl-2-quinolone + electron acceptor
n-valeraldehyde + O2 + H2O
valerate + H2O2
-
-
-
-
?
N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
?
-
-
-
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
DACA-9(10H)-acridone + H2O2
-
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide i.e. DACA, an experimental antitumor agent
-
-
?
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
?
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide-9-(10H)-acridone + H2O2
-
antitumor drug
-
-
?
N1-methyl-nicotineamide + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
N1-methylnicotinamide + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + ?
-
variations in the ratio of the amount of pyridones to the total amount of NMN and pyridones in urine are closely related to the enzyme activity
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
N1-propylnicotinamide + H2O + O2
N1-propyl-2-pyridone-5-carboxamide + N1-propyl-4-pyridone-3-carboxamide + H2O2
NADH + nitrite + H2O + O2
? + nitric oxide
-
in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide. NADH reacts with aldehyde oxidase at the FAD site of the enzyme
-
-
?
nifedipine + H2O + O2
? + H2O2
-
-
-
?
nilutamide + H2O + O2
? + H2O2
-
-
-
?
nimesulide + H2O + O2
? + H2O2
-
-
-
?
nimetazepam + H2O + O2
? + H2O2
-
-
-
?
nimodipine + H2O + O2
? + H2O2
-
-
-
?
nitenpyram + H2O + O2
? + H2O2
-
i.e. (E)-N-[(6-chloropyridin-3-yl)methyl]-N-ethyl-N'-methyl-2-nitroethylene-1,1-diamine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, partial inactivation of neonicotinoid insecticide substrate
-
-
?
nitenpyram + NMNH
nitroso-nitenpyram + amino-nitenpyram + ?
-
-
-
-
?
nithiazine + H2O + O2
? + H2O2
-
i.e. (2Z)-2-(nitromethylene)-1,3-thiazinane, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, partial inactivation of neonicotinoid insecticide substrate
-
-
?
nonanal + H2O + O2
nonanoic acid + H2O2
o-tolualdehyde + H2O + O2
o-methylbenzoic acid + H2O2
-
-
-
-
?
O6-benzylguanine + H2O + O2
O6-benzyl-8-oxoguanine + ?
octanal + H2O + O2
octanoic acid + H2O2
-
-
-
?
octylaldehyde + H2O + O2
octanoate + H2O2
octylaldehyde + O2 + H2O
octanoate + H2O2
-
-
-
-
?
p-aminobenzamidine + H2O + O2
?
-
-
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
p-dimethyl aminocinnamaldehyde + H2O + O2
? + H2O2
-
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
p-methoxybenzaldehyde + H2O + O2
p-methoxybenzoate + H2O2
-
-
-
-
?
p-tolualdehyde + H2O + O2
p-methylbenzoic acid + H2O2
-
-
-
-
?
pentanal + H2O + O2
pentanoic acid + H2O2
PF-4217903 + H2O + O2
?
-
-
-
-
?
PF-945863 + H2O + O2
?
-
-
-
-
?
phenanthrene-9-carboxaldehyde + H2O + O2
phenanthrene-9-carboxylate + H2O2
-
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
phenanthridine + H2O + O2
6-phenantridone + H2O2
phenanthridine + H2O + O2
?
phenanthridine + H2O + O2
phenanthridinone + H2O2
phenanthridine + O2 + H2O
?
-
-
-
-
?
phenothiazine sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetate + H2O2
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
phenylpropionaldehyde + H2O + O2
phenylpropionic acid + H2O2
-
-
-
?
phthalaldehyde + H2O + O2
phthalic acid + H2O2
-
13% of activity with n-hexylaldehyde
-
-
?
phthalazine + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
phthalazine + ferricyanide
1-phthalazinone + ferrocyanide
-
-
-
-
?
phthalazine + ferricyanide
?
-
-
-
-
?
phthalazine + H2O + 2,6-dichlorophenol indophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
phthalazine + H2O + O2
? + H2O2
phthalazine + O2 + H2O
1-phthalazinone + H2O2
propanal + H2O + O2
propanoic acid + H2O2
propionaldehyde + H2O + O2
propionate + H2O2
propionaldehyde + H2O + O2
propionic acid + H2O2
protocatechualdehyde + H2O + O2
protocatechuic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
pteridine + H2O + O2
?
-
-
-
-
?
purine + O2 + H2O
? + H2O2
purine derivative + H2O + ferricyanide
oxidized purine derivative + ?
-
various purine derivatives are listed, this enzyme catalyzes usually a ring methine group vicinal to a ring nitrogen
-
-
?
pyrazolo[3,4-d]pyrimidine + H2O + ferricyanide
oxidized pyrazolo[3,4-d]pyrimidine + ?
-
various pyrazolo[3,4-d]pyrimidines are listed, this enzyme catalyzes usually a ring methine group vicinal to a ring nitrogen
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
quinazolin-4(3H)-one + H2O + O2
quinazoline-2,4(1H,3H)-dione + H2O2
-
-
-
-
?
quinazoline + H2O + O2
?
-
-
-
-
?
quinazoline + H2O + O2
? + H2O2
-
-
-
?
quinine + H2O + O2
?
-
-
-
?
quinoline + H2O + electron donor
?
quinoline + H2O + O2
? + H2O2
-
-
-
?
retinal + O2 + H2O
retinoate + H2O2
retinal + O2 + H2O
retinoic acid + H2O2
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
retinaldehyde + H2O + O2
retinoic acid + H2O2
-
-
-
?
retinaldehyde + O2 + H2O
retinoic acid + H2O2
salicylaldehyde + H2O + O2
salicylic acid + H2O2
salicylaldoxime + H2O + 2-hydroxypyrimidine
salicylaldehyde + NH3 + ?
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
terephthalaldehyde + H2O + O2
terephthalic acid + H2O2
-
45% of activity with n-hexylaldehyde
-
-
?
thiacloprid + H2O + O2
? + H2O2
-
i.e. ((2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene)cyanamide, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, little inactivation of neonicotinoid insecticide substrate
-
-
?
thiamethoxam + H2O + O2
? + H2O2
-
i.e. (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine, enzyme system coupled with Drosophila nicotinic acetylcholine receptor, strong inactivation of neonicotinoid insecticide substrate
-
-
?
tropylium tetrafluoroborate + H2O + ferricyanide
tropone + ?
-
other electron acceptors as dichloroindophenol and chromate
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
valeraldehyde + H2O + O2
valeric acid + H2O2
vanillin + H2O + O2
vanillic acid + H2O2
vanillin + O2 + H2O
vanillic acid + H2O2
veratraldehyde + H2O + O2
veratranoate + H2O2
veratraldehyde + H2O + O2
veratric acid + H2O2
-
18% of activity with n-hexylaldehyde
-
-
?
xanthine + H2O + O2
? + H2O2
xanthine + O2 + H2O
urate + H2O2
-
low activity
-
?
XK-469 + H2O + O2
3-oxo-XK-469 + ?
-
hepatic clearance less than 4.3 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
XK-469 + H2O + O2
?
-
-
-
-
?
Z-3-hexenal + H2O + O2
Z-3-hexenoic acid + H2O2
-
-
-
?
Z11Z13-16Ald + H2O + O2
? + H2O2
low AtraAOX2 activity
-
-
?
zaleplon + H2O + O2
5-oxozaleplon + ?
-
hepatic clearance less than 4.3 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
zaleplon + H2O + O2
?
-
-
-
-
?
zebularine + H2O + O2
uridine + H2O2
zoniporide + H2O + O2
2-oxozoniporide + H2O2
-
i.e. 1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl guanidine
-
-
?
zoniporide + H2O + O2
?
-
-
-
-
?
additional information
?
-
(S)-RS-8359
?
enzyme shows a biphasic pattern in EadieHofstee plots of the (S)-enantiospecific 2-oxidation activity of RS-8359
-
-
?
(S)-RS-8359
?
-
enzyme shows a monophasic pattern in Eadie-Hofstee plots of the (S)-enantiospecific 2-oxidation activity of RS-8359
-
-
?
(S)-RS-8359 + H2O + O2
2-keto-(S)-RS-8359 + H2O2
i.e. 4-([(7S)-7-hydroxy-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]amino)benzonitrile, reversible inhibitor of monoamine oxidase A. Remarkable strain differences in activity on substrate, correlating in part with expressed levels of protein
-
-
?
(S)-RS-8359 + H2O + O2
2-keto-(S)-RS-8359 + H2O2
Donryu rats show a dimorphic pattern for the 2-oxidation activity of RS-8359
-
-
?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
-
51% of activity with formaldehyde
-
-
?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
-
350% of activity with formaldehyde
-
-
?
2-ethylbutylaldehyde + H2O + O2
2-ethylbutanoate + H2O2
-
170% of activity with formaldehyde
-
-
?
2-hydroxypyrimidine + ferricyanide
?
-
-
-
-
?
2-hydroxypyrimidine + ferricyanide
?
-
-
-
-
?
2-hydroxypyrimidine + ferricyanide
?
-
-
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
-
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
diphenylsulfoxide as electron acceptor under anaerobic conditions
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
-
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
-
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
-
-
-
?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
-
-
-
-
?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
-
-
-
?
2-methylbenzaldehyde + H2O + O2
2-methylbenzoate + H2O2
-
7% of activity with n-hexylaldehyde
-
-
?
2-methylbenzaldehyde + H2O + O2
2-methylbenzoate + H2O2
-
7% of activity with n-hexylaldehyde
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
-
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
-
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
-
-
-
-
?
3 brimonidine + 4 H2O + 4 O2
2-oxobrimonidine + 3-oxobrimonidine + 2,3-dioxobrimonidine + 4 H2O2
-
-
-
-
?
3-hydroxypropionaldehyde + H2O + O2
3-hydroxypropionate + H2O2
-
-
-
-
?
3-hydroxypropionaldehyde + H2O + O2
3-hydroxypropionate + H2O2
-
-
-
-
?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
-
-
-
-
?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
-
-
-
?
3-methylbenzaldehyde + H2O + O2
3-methylbenzoate + H2O2
-
42% of activity with n-hexylaldehyde
-
-
?
3-methylbenzaldehyde + H2O + O2
3-methylbenzoate + H2O2
-
42% of activity with n-hexylaldehyde
-
-
?
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
-
i.e. RS-8359, 2-oxidation of the S-enantiomer
-
-
?
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine + H2O + O2
? + H2O2
-
i.e. RS-8359, 2-oxidation of the S-enantiomer
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
-
typical substrate spectrum of aldehyde oxidase
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
-
-
-
?
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
-
-
-
-
?
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
-
-
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
-
12-13% of the activity compared to purine
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O
4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
-
i.e. allopurinol
-
?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
-
-
-
-
?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
-
-
-
?
4-methylbenzaldehyde + H2O + O2
4-methylbenzoate + H2O2
-
40% of activity with n-hexylaldehyde
-
-
?
4-methylbenzaldehyde + H2O + O2
4-methylbenzoate + H2O2
-
40% of activity with n-hexylaldehyde
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
-
-
-
-
?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
-
four aldehyde oxidases are known that have varying affinities to abscisic aldehyde. AOdelta, endcoded by AAO3 specifically catalyses this step in rosette leaves
-
-
?
abscisic aldehyde + H2O + O2
abscisic acid + H2O2
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
-
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
-
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
-
-
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
35% of activity with formaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
is a poor substrate of AOH1
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
is a poor substrate of AOX1
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
350% of activity with formaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
51% of activity with n-hexylaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
51% of activity with n-hexylaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
170% of activity with formaldehyde
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
-
-
-
-
r
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
Megalodesulfovibrio gigas
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
-
?
acetaldehyde + O2 + H2O
acetate + H2O2
-
-
-
-
?
acetaldehyde + O2 + H2O
acetate + H2O2
-
-
-
-
?
acetaldehyde + O2 + H2O
acetate + H2O2
-
-
-
-
?
acetaldehyde + O2 + H2O
acetate + H2O2
-
-
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
-
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
-
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
-
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
other electron acceptors are N-methylnicotinamide, butyraldehyde and benzaldehyde
the corresponding ketimine is an intermediate
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
-
-
-
?
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
-
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
-
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
-
8% of activity with formaldehyde
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
-
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
-
140% of activity with formaldehyde
-
-
?
acrolein + H2O + O2
acrylic acid + H2O2
-
130% of activity with formaldehyde
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
AOH1 from the liver of CD1 mice is capable of oxidizing all-trans retinaldehyde
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
AOH2 from the mouse Harderian gland and AOH3 from the mouse Bowman's gland are all capable of oxidizing all-trans retinaldehyde with equal efficiency
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
-
-
-
?
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
-
-
-
-
?
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
-
-
-
?
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
-
-
-
?
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
130% of activity with formaldehyde
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
160% of activity with formaldehyde
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
41% of activity with n-hexylaldehyde
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
410% of activity with formaldehyde
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
diphenylsulfoxide as electron acceptor under anaerobic conditions and ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
chromate as electron acceptor
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
benzaldehyde + O2 + H2O
benzoate + H2O2
-
-
-
-
?
benzaldehyde + O2 + H2O
benzoate + H2O2
-
-
-
-
?
benzaldehyde + O2 + H2O
benzoate + H2O2
-
-
-
-
?
benzaldehyde + O2 + H2O
benzoate + H2O2
-
-
-
-
?
benzaldehyde + O2 + H2O
benzoate + H2O2
-
-
-
-
?
benzaldehyde + O2 + H2O
benzoate + H2O2
-
-
-
-
?
bombykal + H2O + O2
?
-
-
-
?
bombykal + H2O + O2
?
-
-
-
?
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
butanal + H2O + O2
butanoic acid + H2O2
-
-
-
?
butanal + H2O + O2
butanoic acid + H2O2
-
-
-
?
butanal + H2O + O2
butyric acid + H2O2
-
-
-
-
?
butanal + H2O + O2
butyric acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
butanal + H2O + O2
butyric acid + H2O2
-
ferricyanide as electron donor under aerobic conditions
-
-
?
butanal + H2O + O2
butyric acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
butanal + H2O + O2
butyric acid + H2O2
-
-
-
-
?
butanal + H2O + O2
butyric acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
-
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
31% of activity with formaldehyde
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
-
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
360% of activity with formaldehyde
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
-
-
-
?
butylaldehyde + H2O + O2
butanoate + H2O2
-
260% of activity with formaldehyde
-
-
?
butyraldehyde + H2O + O2
butanoate + H2O2
-
-
-
-
?
butyraldehyde + H2O + O2
butanoate + H2O2
-
-
-
-
r
cinchonidine + H2O + O2
?
-
wild type monkey AOX1 is not able to oxidize chinchonidine, but mutant enzyme V1085A does
-
-
?
cinchonidine + H2O + O2
?
-
rabbit AOX1 has an extremely high Vmax value toward cinchonidine
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
44.2% of the rate with benzaldehyde
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
170% of activity with formaldehyde
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
240% of activity with formaldehyde
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
410% of activity with formaldehyde
-
-
?
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
-
N1-methylnicotinamide and acetaldehyde as electron acceptors under anaerobic conditions
-
-
?
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylindenyl]indene-3-acetic acid + electron acceptor + H2O
5-fluoro-2-methyl-1-[p-(methylthio)benzylindenyl]indene-3-acetic acid + ?
-
N1-methylnicotinamide and acetaldehyde as electron acceptors under anaerobic conditions
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
low AtraAOX2 activity
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
210% of activity with formaldehyde
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
260% of activity with formaldehyde
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
13% of activity with n-hexylaldehyde
-
-
?
citral + H2O + O2
(2E)-3,7-dimethylocta-2,6-dienoic acid + H2O2
-
430% of activity with formaldehyde
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
-
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
-
32% of activity with n-hexylaldehyde
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
-
61% of activity with formaldehyde
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
-
230% of activity with formaldehyde
-
-
?
crotonaldehyde + H2O + O2
crotonic acid + H2O2
-
340% of activity with formaldehyde
-
-
?
decylaldehyde + H2O + O2
decanoate + H2O2
-
41% of activity with formaldehyde
-
-
?
decylaldehyde + H2O + O2
decanoate + H2O2
-
52% of activity with formaldehyde
-
-
?
decylaldehyde + H2O + O2
decanoate + H2O2
-
400% of activity with formaldehyde
-
-
?
diphenyl sulfoxide + acetaldehyde + H2O
?
-
-
-
-
?
diphenyl sulfoxide + acetaldehyde + H2O
?
-
under anaerobic conditions
-
-
?
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
-
28% of activity with formaldehyde
-
-
?
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
-
77% of activity with formaldehyde
-
-
?
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
-
5% of activity with n-hexylaldehyde
-
-
?
DL-glyceraldehyde + H2O + O2
DL-glycerate + H2O2
-
73% of activity with formaldehyde
-
-
?
DL-glyceraldehyde + O2 + H2O
glycerate + H2O2
-
-
-
-
?
DL-glyceraldehyde + O2 + H2O
glycerate + H2O2
-
-
-
-
?
DL-glyceraldehyde + O2 + H2O
glycerate + H2O2
-
-
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
electron donors are 2-hydroxypyrimidine, N1-methylnicotinamide, benzaldehyde or butyraldehyde
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
formaldehyde + H2O + O2
formate + H2O2
-
-
-
-
?
formaldehyde + H2O + O2
formate + H2O2
-
-
-
-
?
formaldehyde + H2O + O2
formate + H2O2
-
-
-
-
?
formaldehyde + H2O + O2
formate + H2O2
-
2% of activity with n-hexylaldehyde, aldehyde oxidase might be effective for the removal of formaldehyde contained in wastewater
-
-
?
formaldehyde + H2O + O2
formate + H2O2
-
-
-
-
?
formaldehyde + H2O + O2
formic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
formaldehyde + H2O + O2
formic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
formaldehyde + H2O + O2
formic acid + H2O2
-
-
-
-
?
formaldehyde + H2O + O2
formic acid + H2O2
-
-
-
-
?
formaldehyde + O2 + H2O
formate + H2O2
-
-
-
-
?
formaldehyde + O2 + H2O
formate + H2O2
-
-
-
-
?
formaldehyde + O2 + H2O
formate + H2O2
-
-
-
-
?
formate + O2
CO2 + H2O2
-
-
-
-
?
formate + O2
CO2 + H2O2
-
-
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
-
18% of activity with formaldehyde
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
-
64% of activity with formaldehyde
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
-
30% of activity with n-hexylaldehyde
-
-
?
glutaraldehyde + H2O + O2
glutarate + H2O2
-
20% of activity with formaldehyde
-
-
?
glyoxal + H2O + O2
glyoxylate + H2O2
-
-
-
-
?
glyoxal + H2O + O2
glyoxylate + H2O2
-
-
-
-
?
glyoxal + H2O + O2
glyoxylate + H2O2
-
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
-
-
-
?
heptylaldehyde + H2O + O2
heptanoate + H2O2
-
76% of activity with formaldehyde
-
-
?
heptylaldehyde + H2O + O2
heptanoate + H2O2
-
350% of activity with formaldehyde
-
-
?
heptylaldehyde + H2O + O2
heptanoate + H2O2
-
480% of activity with formaldehyde
-
-
?
hexanal + H2O + O2
hexanoic acid + H2O2
-
-
-
?
hexanal + H2O + O2
hexanoic acid + H2O2
-
-
-
?
hexanal + H2O + O2
hexanoic acid + H2O2
-
-
-
-
ir
hexanal + H2O + O2
hexanoic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
hexanal + H2O + O2
hexanoic acid + H2O2
-
-
-
?
hexanal + H2O + O2
hexanoic acid + H2O2
-
-
-
-
?
hexylaldehyde + H2O + O2
hexanoate + H2O2
-
74% of activity with formaldehyde
-
-
?
hexylaldehyde + H2O + O2
hexanoate + H2O2
-
-
-
-
?
hexylaldehyde + H2O + O2
hexanoate + H2O2
-
360% of activity with formaldehyde
-
-
?
hexylaldehyde + H2O + O2
hexanoate + H2O2
-
-
-
-
?
hexylaldehyde + H2O + O2
hexanoate + H2O2
-
430% of activity with formaldehyde
-
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 2.0 to 1.8
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 26 to 50
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 80 to 41
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
-
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 10 to 269
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
in presence of N-methylnicotinamide, ratio of amino- to nitroso-products is 23 to 14
-
?
imidacloprid + H2O + O2 + N-methylnicotinamide
nitroso-imidacloprid + amino-imidacloprid + H2O2 + ?
-
-
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
-
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
-
20% of activity with formaldehyde
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
-
8% of activity with formaldehyde
-
-
?
indol-3-carboxyaldehyde + H2O + O2
indol-3-carboxylic acid + H2O2
-
100% of activity with formaldehyde
-
-
?
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
-
48.0% of the rate with benzaldehyde
-
-
?
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
-
-
-
?
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
indole 3-carbaldehyde + H2O + O2
indole 3-carboxylate + H2O2
-
-
-
-
?
indole 3-carbaldehyde + H2O + O2
indole 3-carboxylate + H2O2
-
2,6-dichlorophenol-indophenol also as electron acceptor
-
-
?
indole-3-aldehyde + H2O + O2
indole-3-carboxylate + H2O2
-
-
-
-
?
indole-3-aldehyde + H2O + O2
indole-3-carboxylate + H2O2
-
-
-
?
indole-3-aldehyde + H2O + O2
indole-3-carboxylic acid + H2O2
-
-
-
-
?
indole-3-aldehyde + H2O + O2
indole-3-carboxylic acid + H2O2
-
-
-
-
?
indole-3-aldehyde + H2O + O2
indole-3-carboxylic acid + H2O2
-
-
-
-
?
indole-3-aldehyde + H2O + O2
indole-3-carboxylic acid + H2O2
-
-
-
-
?
indole-3-aldehyde + O2 + H2O
indole-3-carboxylate + H2O2
-
-
-
-
?
indole-3-aldehyde + O2 + H2O
indole-3-carboxylate + H2O2
-
-
-
-
?
methotrexate + H2O + O2
7-hydroxymethotrexate + H2O2
-
-
-
?
methotrexate + H2O + O2
7-hydroxymethotrexate + H2O2
-
-
-
?
methotrexate + H2O + O2
7-hydroxymethotrexate + H2O2
-
-
-
-
?
methotrexate + H2O + O2
?
-
-
-
-
?
methotrexate + H2O + O2
?
-
-
-
?
N-methylquinolinium + H2O + electron donor
N-methyl-4-quinolone and N-methyl-2-quinolone + electron acceptor
-
-
-
-
?
N-methylquinolinium + H2O + electron donor
N-methyl-4-quinolone and N-methyl-2-quinolone + electron acceptor
-
electron donors are ferricyanide and cytochrome c
-
-
?
N-phenylquinolinium + H2O + electron donor
N-phenyl-4-quinolone and N-phenyl-2-quinolone + electron acceptor
-
-
-
-
?
N-phenylquinolinium + H2O + electron donor
N-phenyl-4-quinolone and N-phenyl-2-quinolone + electron acceptor
-
electron donors are ferricyanide and cytochrome c
-
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
diphenylsulfoxide as electron acceptor under anaerobic conditions and ferricyanide as electron acceptor under aerobic conditions
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
potassium ferricyanide acts as electron acceptor
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
chromate as electron acceptor, reduction of chromate
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
cytochrome c reduction under aerobic conditions
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
N1-propylnicotinamide + H2O + O2
N1-propyl-2-pyridone-5-carboxamide + N1-propyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-propylnicotinamide + H2O + O2
N1-propyl-2-pyridone-5-carboxamide + N1-propyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
nonanal + H2O + O2
nonanoic acid + H2O2
-
-
-
?
nonanal + H2O + O2
nonanoic acid + H2O2
-
-
-
?
O6-benzylguanine + H2O + O2
O6-benzyl-8-oxoguanine + ?
-
-
-
-
?
O6-benzylguanine + H2O + O2
O6-benzyl-8-oxoguanine + ?
-
hepatic clearance of 11.2 to 12.8 ml/(min * kg)
product identification by high-resolution mass spectrometry
-
?
octylaldehyde + H2O + O2
octanoate + H2O2
-
64% of activity with formaldehyde
-
-
?
octylaldehyde + H2O + O2
octanoate + H2O2
-
350% of activity with formaldehyde
-
-
?
octylaldehyde + H2O + O2
octanoate + H2O2
-
430% of activity with formaldehyde
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
-
40.2% of the rate with benzaldehyde
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
-
180% of activity with formaldehyde
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
-
190% of activity with formaldehyde
-
-
?
p-anisaldehyde + H2O + O2
p-anisic acid + H2O2
-
500% of activity with formaldehyde
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
-
54.8% of the rate with benzaldehyde
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
-
200% of activity with formaldehyde
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
-
-
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
-
250% of activity with formaldehyde
-
-
?
p-hydroxybenzaldehyde + H2O + O2
p-hydroxybenzoate + H2O2
-
320% of activity with formaldehyde
-
-
?
pentanal + H2O + O2
pentanoic acid + H2O2
-
-
-
?
pentanal + H2O + O2
pentanoic acid + H2O2
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
-
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
-
-
-
?
phenanthridine + H2O + O2
6-phenantridone + H2O2
-
-
-
?
phenanthridine + H2O + O2
6-phenantridone + H2O2
-
-
-
-
?
phenanthridine + H2O + O2
6-phenantridone + H2O2
-
products are about 85-90% hydrogen peroxide and 6-10% superoxide anion
-
-
?
phenanthridine + H2O + O2
6-phenantridone + H2O2
-
oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine
-
-
?
phenanthridine + H2O + O2
?
-
-
-
?
phenanthridine + H2O + O2
?
activity of rabbit liver aldehyde oxidase characterized in nine water-miscible organic mixtures i.e. phosphate buffer mixed with N-N-dimethylformamide, acetonitrile, tetrahydrofuran, 1-propanol, 2-propanol, ethanol, pyridine, dioxane, and methanol
-
-
?
phenanthridine + H2O + O2
?
-
inhibitory effects of 15 flavonoids on the activity of rat liver aldehyde oxidase assessed, glycosylated flavonoids show relatively weaker inhibition, quantitative structureactivity relationship studies performed to elucidate the important structural properties responsible for the observed inhibitory effects
-
-
?
phenanthridine + H2O + O2
?
-
inhibitory effects of 15 flavonoids on the activity of rat liver aldehyde oxidase assessed, glycosylated flavonoids show relatively weaker inhibition, quantitative structureactivity relationship studies performed to elucidate the important structural properties responsible for the observed inhibitory effects
-
-
?
phenanthridine + H2O + O2
phenanthridinone + H2O2
-
-
-
?
phenanthridine + H2O + O2
phenanthridinone + H2O2
-
-
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetate + H2O2
-
26% of activity with formaldehyde
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetate + H2O2
-
130% of activity with formaldehyde
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetate + H2O2
-
230% of activity with formaldehyde
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
-
?
phthalazine + H2O + O2
? + H2O2
-
-
-
-
?
phthalazine + H2O + O2
? + H2O2
-
-
-
?
phthalazine + O2 + H2O
1-phthalazinone + H2O2
-
-
-
-
?
phthalazine + O2 + H2O
1-phthalazinone + H2O2
-
-
-
-
?
propanal + H2O + O2
propanoic acid + H2O2
highest AtraAOX2 activity
-
-
?
propanal + H2O + O2
propanoic acid + H2O2
-
-
-
?
propanal + H2O + O2
propanoic acid + H2O2
-
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
23% of activity with formaldehyde
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
340% of activity with formaldehyde
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
220% of activity with formaldehyde
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
-
-
-
-
r
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
ferricyanide and 2,6-dichlorophenol-indophenol as electron acceptor under aerobic conditions
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
Megalodesulfovibrio gigas
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
-
?
purine + O2 + H2O
? + H2O2
-
-
-
?
purine + O2 + H2O
? + H2O2
-
best substrate tested
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
-
-
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
-
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
-
-
-
-
?
quinoline + H2O + electron donor
?
-
-
-
-
?
quinoline + H2O + electron donor
?
-
ferricyanide as electron donor under aerobic conditions
-
-
?
quinoline + H2O + electron donor
?
-
chromate as electron donor
-
-
?
quinoline + H2O + electron donor
?
-
ferricyanide and cytochrome c as electron donor
-
-
?
retinal + O2 + H2O
retinoate + H2O2
-
-
-
?
retinal + O2 + H2O
retinoate + H2O2
-
-
-
?
retinal + O2 + H2O
retinoate + H2O2
-
-
-
?
retinal + O2 + H2O
retinoate + H2O2
-
-
-
?
retinal + O2 + H2O
retinoate + H2O2
-
involved in vitamin A metabolism, increased activity of cells in hyperthyroidism, decreased activity of cells in hypothyroidism
-
?
retinal + O2 + H2O
retinoate + H2O2
-
activity is dependent on vitamin A levels of tissues
-
?
retinal + O2 + H2O
retinoic acid + H2O2
-
-
-
?
retinal + O2 + H2O
retinoic acid + H2O2
-
-
-
?
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
-
?
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
?
retinaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
-
?
retinaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
Megalodesulfovibrio gigas
-
2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
22% of activity with formaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
120% of activity with formaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
8% of activity with n-hexylaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
8% of activity with n-hexylaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
260% of activity with formaldehyde
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
-
56% of activity with formaldehyde
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
-
360% of activity with formaldehyde
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
-
67% of activity with n-hexylaldehyde
-
-
?
valeraldehyde + H2O + O2
valerate + H2O2
-
350% of activity with formaldehyde
-
-
?
valeraldehyde + H2O + O2
valeric acid + H2O2
-
ferricyanide as electron acceptor under aerobic conditions
-
-
?
valeraldehyde + H2O + O2
valeric acid + H2O2
-
-
-
-
?
valeraldehyde + H2O + O2
valeric acid + H2O2
-
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
low AtraAOX2 activity
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
43.3% of the rate with benzaldehyde
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
Q84IX9; Q84IY0 andQ84IX8
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
17% of activity with n-hexylaldehyde
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
-
?
vanillin + O2 + H2O
vanillic acid + H2O2
-
-
-
-
?
vanillin + O2 + H2O
vanillic acid + H2O2
-
-
-
-
?
vanillin + O2 + H2O
vanillic acid + H2O2
-
-
-
-
?
veratraldehyde + H2O + O2
veratranoate + H2O2
-
120% of activity with formaldehyde
-
-
?
veratraldehyde + H2O + O2
veratranoate + H2O2
-
220% of activity with formaldehyde
-
-
?
veratraldehyde + H2O + O2
veratranoate + H2O2
-
610% of activity with formaldehyde
-
-
?
xanthine + H2O + O2
? + H2O2
lowest AtraAOX2 activity
-
-
?
xanthine + H2O + O2
? + H2O2
-
-
-
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
zonisamide + H2O + O2
?
-
-
-
-
?
zonisamide + H2O + O2
?
-
-
-
-
?
additional information
?
-
AtraAOX2 shows strong activity on aldehyde substrates derived from plants, but weak activity on Z11Z1316Ald, AtraAOX2 does not degrade the carbamate insecticide aldicarb
-
-
?
additional information
?
-
-
AtraAOX2 shows strong activity on aldehyde substrates derived from plants, but weak activity on Z11Z1316Ald, AtraAOX2 does not degrade the carbamate insecticide aldicarb
-
-
?
additional information
?
-
-
no substrate: citral, hexanal
-
-
?
additional information
?
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
no substrates: glycolate and alcohols such as ethanol, 1-propanol, 2-methoxyethanol, ethylene glycol and glycerol
-
-
?
additional information
?
-
-
no substrate: zebularine
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
-
also electron acceptors are dibenzyl sulfoxide, phenothiazine sulfoxide, D-biotin methyl ester d-sulfoxide and quinoline N-oxide
-
-
?
additional information
?
-
-
no substrate: xanthine, allopurinol, isoquinoline
-
-
?
additional information
?
-
-
no substrate: xanthine, allopurinol, isoquinoline
-
-
?
additional information
?
-
enzyme is devoid of xanthine oxidase or hypoxanthine oxidase activity
-
-
?
additional information
?
-
enzyme is devoid of xanthine oxidase or hypoxanthine oxidase activity
-
-
?
additional information
?
-
-
enzyme is devoid of xanthine oxidase or hypoxanthine oxidase activity
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
no substrate: 6-nitroquinazoinone
-
-
?
additional information
?
-
-
hepatic clearance for substrates of aldehyde oxidase i.e. BIBX1382, carbazeran, O6-benzylguanine, zaleplon, and XK-469 is investigated using cryopreserved hepatocytes
confirmation of aldehyde oxidase mediated metabolism via incubations in the presence of water containing the 18-O isotope and corresponding isotope patterns in mass spectra
-
?
additional information
?
-
-
catalyzes the last step of indole-3-acetic acid biosynthesis. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of enzyme expression and activity may be involved in regulation of nodule development
-
-
?
additional information
?
-
-
the enzyme catalyzes the last step of indole-3-acetic acid biosynthesis in plants, in the root nodules. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of aldehyde oxidase expression and activity are involved in regulation of nodule development
-
-
?
additional information
?
-
enzyme may be involved in degradation of aldehyde odorant compounds such as pheromones or plants volatiles
-
-
?
additional information
?
-
-
enzyme may be involved in degradation of aldehyde odorant compounds such as pheromones or plants volatiles
-
-
?
additional information
?
-
-
catalyzes the last step of indole-3-acetic acid biosynthesis. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of enzyme expression and activity may be involved in regulation of nodule development
-
-
?
additional information
?
-
-
no substrate: heptaldehyde
-
-
?
additional information
?
-
-
the enzyme catalyzes the last step of indole-3-acetic acid biosynthesis in plants, in the root nodules. Local synthesis of indole-3-acetic acid in the root nodule meristem and modulation of aldehyde oxidase expression and activity are involved in regulation of nodule development
-
-
?
additional information
?
-
-
enzyme plays an important role in detoxification of the toxic heterocycles synthesized by certain plants
-
-
?
additional information
?
-
Q84IX9; Q84IY0 andQ84IX8
no substrates: xanthine and N'-methylnicotinamide
-
-
-
additional information
?
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
no substrate: xanthine, hypoxanthine
-
-
?
additional information
?
-
-
no substrate: xanthine, hypoxanthine
-
-
?
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
-
electron acceptors are molecular oxygen, several dyes, ferricyanide, silicomolybdate and organic nitro compounds
-
-
?
additional information
?
-
-
various imidazole, pyrazole, pyridine, pyrazine, pyrimidine, purine, quinoline and pteridine derivatives are substrates for this enzyme, preferences of substitutions are discussed
-
-
?
additional information
?
-
-
various unsubstituted aglycones and some ribonucleosides of various purine analogs are also substrates for this enzyme
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
isoforms AO-alpha and AO-beta cannot oxidize abscisic aldehyde
-
-
?
additional information
?
-
isoforms AO-alpha and AO-beta cannot oxidize abscisic aldehyde
-
-
?
additional information
?
-
isoforms AO-alpha and AO-beta cannot oxidize abscisic aldehyde
-
-
?
additional information
?
-
isoforms AO-alpha and AO-beta cannot oxidize abscisic aldehyde
-
-
?
additional information
?
-
enzyme oxidizes both sex pheromone compounds as well as plant-derived aldehydes with distinct activities
-
-
-
additional information
?
-
-
enzyme oxidizes both sex pheromone compounds as well as plant-derived aldehydes with distinct activities
-
-
-
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
enzyme is of interest as a source of the reactive oxygen species, hydrogen peroxide and the superoxide anion
-
-
?
additional information
?
-
-
a wide variety of xenobiotics may serve as electron acceptors instead of molecular oxygen. Enzyme reduces nitroguanidines to both nitroso- and aminoguanidines, while nitromethylens are reduced only to the corrsponding nitroso metabolites. Reduction of nitroguanidines to amino metabolites depends on enzyme concentration
-
-
?
additional information
?
-
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
low and negligible quinine-oxidizing activity
-
-
?
additional information
?
-
-
phenanthridine N-oxide is not metabolized by the enzyme
-
-
?
additional information
?
-
-
enzyme may be involved in synthesis of reactive oxygen species during water stress
-
-
?
additional information
?
-
-
enzyme produces H2O2, but not O2, and requires a Moco sulfurase domain
-
-
?
additional information
?
-
-
no activities toward N1-methylnicotinamide, quinoline, xanthine, methanol, and ethanol
-
-
?
additional information
?
-
-
no activities toward N1-methylnicotinamide, quinoline, xanthine, methanol, and ethanol
-
-
?
additional information
?
-
-
oxidation of substrates by aldehyde oxidase appears to be due primarily to the electronic effects of the substituents
-
-
?
additional information
?
-
-
3(4,5-dimethylthiazolyl-2)2,5-diphenyltetrazolium-bromide, ferricyanide and cytochrome c can also act as electron acceptors, the latter two are not so efficient
-
-
?
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(Z)1,11-hexadecadien-3-one
-
slight inhibition
1-benzyl-3-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]thiourea
-
comparison with inhibition of xanthine oxidase
2,4-dinitrophenol
50 microM, 41.7% residual AtraAOX2 activity
2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine
-
comparison with inhibition of xanthine oxidase
2-(methylthio)-6-nitro-3-phenyl-3,4-dihydroquinazoline
-
comparison with inhibition of xanthine oxidase
2-Aminobenzaldehyde
-
complete inhibition at 5 mM, partially reversed by retinal
2-Hydroxy-1,4-naphthoquinone
-
specific inhibitor of enzyme in vitro, 50% inhibition of phenanthridine oxidation at 0.0093 mM
2-mercaptoethanol
-
40% inhibition at 5 mM
3,4,5-trimethoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
3,4,5-trimethoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
3,4-Dihydroxybenzaldehyde
-
0.01 mM, 50% and 76% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM, 87% inhibition of 2-hydroxy-benzaldehyde oxidation
3,4-dimethoxy-2-phenylethylamine
-
0.1 mM and 1 mM, 48% and 100% inhibition of benzaldehyde oxidation, respectively
3,4-dimethoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
3,4-dimethoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
3-benzyl-2-(methylthio)-3,4-dihydroquinazolin-6-amine
-
comparison with inhibition of xanthine oxidase
3-benzyl-2-(methylthio)-6-nitro-3,4-dihydroquinazoline
-
comparison with inhibition of xanthine oxidase
3-benzyl-6-nitro-3,4-dihydroquinazoline-2-thiol
-
comparison with inhibition of xanthine oxidase
3-ethyl-2-(methylthio)-6-nitro-3,4-dihydroquinazoline
-
comparison with inhibition of xanthine oxidase
3-ethyl-6-nitro-3,4-dihydroquinazoline-2-thiol
-
comparison with inhibition of xanthine oxidase
3-Hydroxy-4-methoxybenzaldehyde
-
0.1 mM, 87% and 85% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM, 87% inhibition of 2-hydroxy-benzaldehyde oxidation
4'-(9-acridinylamino)methanesulfonaniside
-
dose-dependent inhibition, no complete inhibition
4'-(9-acrydinylamino)methanesulfon-m-anisidide
-
competitive inhibitor
4'-(9-acrydinylamino)methanesulfon-o-anisidide
-
-
4-bromo-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzenesulfonamide
-
comparison with inhibition of xanthine oxidase
4-hydroxy-3-methoxy-2-phenylethylamine
-
0.1 mM and 1 mM, 21% and 55% inhibition of benzaldehyde oxidation, respectively
4-hydroxymercuribenzoate
50 microM, 55.3% residual AtraAOX2 activity
4-methoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
4-methoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
4-methyl-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
4-methyl-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
6-nitro-3-phenyl-3,4-dihydroquinazoline-2-thiol
-
comparison with inhibition of xanthine oxidase
8-hydroxyquinoline
-
1 mM, 20% residual activity
9-aminoacridine
-
competitive inhibitor
acetaldehyde
-
77% inhibition at 5 mM, partially reversed by retinal
adiponectin
downregulates AOX1 expression by activating peroxisome proliferator-activated receptor-alpha
-
alpha,alpha'-dipyridyl
-
1 mM, 49% residual activity
amidol
-
complete inhibition of sulfoxide reductase and aldehyde oxidase activity at 0.2 mM
amitriptyline
-
0.00026 mM, 50% inhibition
amlodipine
-
0.0055 mM, 50% inhibition
amodiaquine
-
0.00074 mM, 50% inhibition
antimycin A
10 microM, 45.6% residual AtraAOX2 activity
aspartate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
azide
-
slight inhibition
beta-ecdysone
50 microM, 30.1% residual AtraAOX2 activity
catechol
-
0.1 mM and 1 mM, 64% and 98% inhibition of benzaldehyde oxidation, respectively
cimetidine
-
0.5 mM, 50% inhibition of reaction without added electron donor
clomipramine
-
0.00048 mM, 50% inhibition
CuSO4
-
85% inhibition at 0.1 mM
cyclobenzaprine
-
0.0031 mM, 50% inhibition
Digitonin
125 microM, 69.9% residual AtraAOX2 activity
diphenylsulfoxide
-
85% inhibition at 0.1 mM, it serves as an inhibitor in presence of other electron acceptors
dithiothreitol
-
45% and 92% inhibition at 0.1 mM and 1 mM respectively
dopamine
-
0.1 mM, 80% and 93% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM and 1 mM, 59% and 100% inhibition of benzaldehyde oxidation, respectively
DTT
-
more than 50% inhibition at 1.6 mM
ellagic acid
-
noncompetitive
epigallocatechin gallate
-
competitive
erythromycin
-
0.015 mM, 50% inhibition
estrogen
reduces liver aldehyde oxidase activity of male animals; reduces liver aldehyde oxidase activity of male animals; reduces liver aldehyde oxidase activity of male animals; reduces liver aldehyde oxidase activity of male animals; reduces liver aldehyde oxidase activity of male animals
Fe2+
-
1 mM, no residual activity
felodipine
-
0.00030 mM, 50% inhibition
glutamate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels; neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
hydrazine
-
1 mM, 28% residual activity
hydroxyamine
-
1 mM, 52% residual activity
hydroxytoluene
-
butylated, 50% inhibition at 1 mM
iodoacetate
-
31% inhibition at 1 mM
ketoconazole
-
0.0035 mM, 50% inhibition
L-Dopa
-
0.1 mM and 1 mM, 39% and 94% inhibition of benzaldehyde oxidation, respectively
loperamide
-
0.010 mM, 50% inhibition
loratidine
-
0.00049 mM, 50% inhibition
loxapine
-
0.0023 mM, 50% inhibition
maprotiline
-
0.0014 mM, 50% inhibition
methadone
0.1 mM, 68% inhibition
metoclopramide
-
0.031 mM, 50% inhibition
MgCl2
-
1 mM, 62% residual activity
Mo5+
-
1 mM, 6% residual activity
N-hydroxy-2-acetylamino-biphenyl
-
15%, 51% and 88% inhibition at 0.001 mM, 0.01 mM and 0.1 mM respectively
N-hydroxy-2-acetylamino-fluorene
-
38% and 88% inhibition at 0.001 mM and 0.01 mM respectively, protection against inhibition in the presence of dithiothreitol, cysteine and glutathione, noncompetitive inhibitor
N-hydroxy-2-propionylamino-fluorene
-
25% and 52% inhibition at 0.001 mM and 0.01 mM respectively
N-hydroxyphenacetin
-
4%, 27% and 44% inhibition at 0.001 mM, 0.01 mM and 0.1 mM respectively
N-methylnicotinamide
-
competitive inhibition
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine
-
comparison with inhibition of xanthine oxidase
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine
-
comparison with inhibition of xanthine oxidase
N-[(1E)-(3,4-dimethoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine
-
comparison with inhibition of xanthine oxidase
N-[(1E)-(3,4-dimethoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine
-
comparison with inhibition of xanthine oxidase
N-[(1E)-(4-methoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine
-
comparison with inhibition of xanthine oxidase
N-[(1E)-(4-methoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine
-
comparison with inhibition of xanthine oxidase
N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide
-
comparison with inhibition of xanthine oxidase
nitrate
-
moderate inhibitor
noradrenaline
-
0.1 mM, 51% and 95% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM and 1 mM, 90% and 100% inhibition of benzaldehyde oxidation, respectively
norclomipramine
-
0.00060 mM, 50% inhibition
nortriptyline
-
0.00085 mM, 50% inhibition
olanzapine
-
0.0060 mM, 50% inhibition
ondansetron
-
0.0021 mM, 50% inhibition
p-benzoquinone
-
strong inhibitor
p-chloromercuribenzoic acid
p-dimethylaminocinnamaldehyde
-
effective inhibitor, more pronounced at higher pH values
p-hydroxymercuribenzoate
-
complete inhibition at 3 mM, reversed by DTT
perphenazine
-
0.00003 mM, 50% inhibition
phosphate
-
moderate inhibitor
potassium cyanide
1 mM, 71.8% residual AtraAOX2 activity
promazine
-
0.0016 mM, 50% inhibition
propafenone
-
0.0025 mM, 50% inhibition
propyl 3,4,5-trihydroxybenzoate
-
91% inhibition at 3 mM
Pyridine
non-linear inhibition
quinocrine
-
59-63% inhibition of sulfoxide reductase and aldehyde oxidase activity at 0.1 mM
quinolinic acid
-
competitive
retinol
-
complete inhibition at 0.5 mM
rotenone
10 microM, 89.3% residual AtraAOX2 activity
salmeterol
-
0.0099 mM, 50% inhibition
scopoletin
-
moderate inhibition, effect on superoxide anion formation is more pronounced than effect on hydrogen peroxide formation or substrate oxidation
selenium
-
enzyme activity towards substrates (S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine and vanillin is increased by selenium deficiency to 250% of initial rate, and this corresponds to an increase of Aox1 protein level, but not to a decrease in mRNA level
siRNA
knock-down of AOX1 in HepG2 cells, significantly reduces ABCA1-dependent lipid efflux and enhances phagocytic uptake of microspheres similar to ABCA1 deficiency, without affecting ABCA1 mRNA and protein levels
-
Sodium azide
5 mM, 52.4% residual AtraAOX2 activity
superoxid dismutase
-
complete inhibition at 0.001 mM
-
tacrine
-
0.0050 mM, 50% inhibition
thioridazine
-
0.00016 mM, 50% inhibition
Trifluperazine
-
0.00024 mM, 50% inhibition
verapamil
-
0.0035 mM, 50% inhibition
Zn2+
-
1 mM, 67% residual activity
5-benzylacyclouridine
-
50% inhibition at about 0.25 mM
5-benzylacyclouridine
-
50% inhibition at about 0.8 mM
5-benzylacyclouridine
-
50% inhibition at about 0.8 mM
5-benzylacyclouridine
-
50% inhibition at about 0.3 mM
allopurinol
-
45% inhibition at 0.25 mM
allopurinol
-
at 0.01 mM, 13% inhibition of 0.1 mM substrate benzaldehyde, 6% inhibition of 0.05 mM substrate phenanthridine, 7% inhibition of 0.05 mM substrate vanillin
allopurinol
does not affect the extent of the oxidation reactions of 5-nitroquinoline but instead increases the amount of reductive metabolite produced by around 60%
Amytal
-
54% inhibition at 1 mM
Amytal
-
48% inhibition at 0.2 mM
arsenite
-
82-95% inhibition of sulfoxide reductase and aldehyde oxidase activity at 0.1 mM
arsenite
-
65% inhibition at 20 mM
benzamidine
-
75% inhibition at 0.1 mM
benzamidine
-
1 mM, 58% inhibition
beta-carboline
-
-
beta-carboline
a far better inhibitor of mouse AOH1 than AOX1; a far better inhibitor of mouse AOH1 than AOX1
beta-estradiol
50 microM, 60.2% residual AtraAOX2 activity
beta-estradiol
-
90% inhibition at 0.02 mM
beta-estradiol
-
51% inhibition at 0.004 mM
chlorpromazine
-
-
chlorpromazine
-
80% inhibition of sulfoxide reductase and aldehyde oxidase activity at 0.2 mM
chlorpromazine
-
0.1 mM, about 95% inhibition
chlorpromazine
-
0.00057 mM, 50% inhibition
chlorpromazine
-
94% inhibition at 0.1 mM
chlorpromazine
-
0.5 mM, 48% inhibition of reaction without added electron donor
clozapine
-
0.0044 mM, 50% inhibition
Cu2+
-
1 mM, 95% inhibition
Cu2+
-
1 mM, 4% residual activity
dicoumarol
-
-
dicoumarol
-
33% inhibition of sulfoxide reductase and aldehyde oxidase activity at 0.01 mM
dicoumarol
-
43% inhibition at 0.1 mM
domperidone
-
0.0030 mM, 50% inhibition
estradiol
-
0.00029 mM, 50% inhibition
estradiol
-
uncompetitive, with no inhibition towards the tested CYP450 enzymes
ethanol
2% (v/v), 62.1% residual AtraAOX2 activity
ethanol
-
0.75 M, 40% inhibition
ethinyl estradiol
-
0.00057 mM, 50% inhibition
fenofibrate
-
in mature adipocytes, enzyme expression is reduced in presence of 50 microM fenofibrate
fenofibrate
-
in mature adipocytes, enzyme expression is reduced in presence of 50 microM fenofibrate
hesperetin
-
-
hydralazine
-
upon coincubation of BIBX1382, carbazeran, and O6-benzylguanine with 50 microM hydralazine, metabolic clearance is substantially attenuated
hydralazine
-
100 microM reduces enzyme activity by as much as 96%
hydralazine
inhibits all three reactions of 5-nitroquinoline
Isopropanol
2% (v/v), 67.9% residual AtraAOX2 activity
Isopropanol
-
moderate inhibitor
isovanillin
-
1 mM, approx. 96% inhibition after 120 min
KCN
-
-
KCN
-
complete inhibition at 1 mM when preincubated for 5 min
KCN
-
95% inhibition of sulfoxide reductase and aldehyde oxidase activity at 0.25 mM
KCN
-
95% inhibition at 1 mM
KCN
-
46% inhibition at 0.2 mM
KCN
-
59% inhibition at 0.2 mM
KCN
-
1 mM, 18% inhibition of reaction without added electron donor
menadione
100 microM, 63.1% residual AtraAOX2 activity
menadione
-
complete inhibition at 0.1 mM
menadione
-
95% inhibition at 0.02 mM
menadione
-
at 0.01 mM, 80% inhibition of 0.1 mM substrate benzaldehyde, 96% inhibition of 0.05 mM substrate phenanthridine, 89% inhibition of 0.05 mM substrate vanillin
menadione
-
0.1 mM, about 95% inhibition
menadione
-
inhibitory versus substrates vanillin and phenanthridine, activating versus substrate xanthine
menadione
-
noncompetitive
menadione
-
0.00020 mM, 50% inhibition
menadione
-
specific inhibitor of aldehyde oxidase
menadione
-
91.5% inhibition at 0.01 mM
menadione
-
slight inhibition at 0.005 mM
menadione
-
0.006 mM, 0.0042 mM, 0.0026 mM, 0.001 mM, 0.0014 mM and 0.0008 mM, 50% inhibition of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide oxidation in male swiss CD mouse, CB57BI/6J, female swiss CD mouse, nude mouse, nude mouse tumor bearing and C129/C57 muse, respectively
menadione
-
0.005 mM, 74% inhibition; 0.005 mM, 87% inhibition
menadione
-
complete inhibition at 0.05 mM
menadione
-
complete inhibition of tropylium ion oxidation at 0.003 mM
menadione
-
59% inhibition at 0.2 mM
menadione
-
0.2 mM, 78% inhibition of reaction without added electron donor
menadione
-
standard aldehyde oxidase inhibitor
methanol
2% (v/v), 33.9% residual AtraAOX2 activity
methanol
-
0.75 M, 62% inhibition
morin
-
-
myricetin
-
inhibition of both aldehyde oxidase and xanthine oxidase
naringenin
-
-
norharman
-
50% inhibition at 0.01 mM
norharman
-
slight inhibition at 0.02 mM
norharmane
-
0.02 mM, 87% inhibition
p-chloromercuribenzoate
-
1 mM, 88% inhibition
p-chloromercuribenzoate
-
1 mM, 94% inhibition
p-chloromercuribenzoate
-
1 mM, 90% inhibition
p-chloromercuribenzoic acid
-
-
p-chloromercuribenzoic acid
-
95% inhibition of sulfoxide reductase and aldehyde oxidase activity at 0.1 mM
p-chloromercuribenzoic acid
-
96% inhibition at 0.1 mM
p-chloromercuribenzoic acid
-
61% inhibition at 0.05 mM
palmitic acid
-
enzyme expression is reduced in 3T3-L1 cells differentiated in presence of 400 microM palmitic acid
palmitic acid
-
enzyme expression is reduced in 3T3-L1 cells differentiated in presence of 400 microM palmitic acid
phenylhydrazine
-
1 mM, 6% residual activity
phenylhydrazine
-
1 mM, 12% residual activity
Promethazine
-
0.00051 mM, 50% inhibition
Promethazine
-
0.5 mM, 28% inhibition of reaction without added electron donor
quercetin
-
at 0.01 mM, 96% inhibition of 0.1 mM substrate benzaldehyde, 69% inhibition of 0.05 mM substrate phenanthridine, 91% inhibition of 0.05 mM substrate vanillin. Mixed type inhibition for all three substrates
quercetin
-
inhibition of both aldehyde oxidase and xanthine oxidase
quercetin
-
mixed type inhibition
quetiapine
-
0.0014 mM, 50% inhibition
quetiapine
-
additionally shows inhibition towards the major CYP450 enzymes tested
Quinacrine
1 mM, 34.9% residual AtraAOX2 activity
Quinacrine
-
0.0033 mM, 50% inhibition
Quinacrine
-
74% inhibition at 0.1 mM
Quinacrine
-
45% inhibition at 0.002 mM
Quinacrine
-
76% inhibition at 1 mM, partially reversed by FAD
raloxifene
-
0.000003 mM, 50% inhibition
raloxifene
-
50% inhibition at about 8 nM
raloxifene
-
specific inhibitor of aldehyde oxidase, complete inhibition at 0.01 mM
raloxifene
-
additionally acts as non-specific inhibitor of all major tested CYP450 enzymes
raloxifene
-
50% inhibition at about 500 nM
raloxifene
-
50% inhibition at about 500 nM
raloxifene
-
50% inhibition above 1100 nM
raloxifene
-
aldehyde oxidase inhibitor, significantly decreases NO generation from nitrite in heart or liver
raloxifene
-
inhibits substrate binding at the molybdenum site of the enzyme
rutin
-
at 0.01 mM, 52% inhibition of 0.1 mM substrate benzaldehyde, 27% inhibition of 0.05 mM substrate phenanthridine, 34% inhibition of 0.05 mM substrate vanillin. Mixed type inhibition for benzaldehyde and vanillin, non-competitive with phenanthridine
SKF 525-A
-
62% inhibition at 0.1 mM
SKF 525-A
-
60% inhibition at 0.05 mM
tamoxifen
-
0.0022 mM, 50% inhibition
Triton X-100
0.01% (v/v), 71.8% residual AtraAOX2 activity
Triton X-100
-
28% and 63% inhibition at 0.007% with O2 and diphenylsulfoxide as electron acceptor respectively
Triton X-100
-
76% inhibition at 0.0008%
additional information
hydroquinone and sodium deoxycholate have no inhibitory effect
-
additional information
-
hydroquinone and sodium deoxycholate have no inhibitory effect
-
additional information
-
oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine. A rather plan structure is essential for a potent inhibitory effect and substitution by sugar moieties reduces the inhibitory effects
-
additional information
-
addition of 100 microM allopurinol has no significant effect on enzyme activity
-
additional information
-
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice; activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
-
some purine and pyrazolo[3,4-d]pyrimidines as well as various unsustituted aglycones and some ribonucleosides of various purine analogs are also inhibitors of this enzyme
-
additional information
-
under alkaline conditions, prominent inhibition of NO generation by aldehyde oxidase occurs
-
additional information
-
low aldehyde oxidase activity groups are the Slc:Wistar, Crl:SD, F344/DuCrlCrlj, and Slc:SD strains
-
additional information
-
not inhibitory: diphenyleneiodonium
-
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0.0109 - 0.131
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
0.0352 - 0.147
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
0.0341 - 0.0407
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
0.0027 - 0.173
(S)-RS-8359
0.12
1-methyl-3-acetylpyridine
-
ferricyanide as electron acceptor
0.0021 - 0.2525
2,4-dihydroxybenzaldehyde
0.007
2,6-dichlorophenolindophenol
-
as electron acceptor under aerobic conditions
0.57 - 3.5
2-ethylbutylaldehyde
0.02
2-Hydroxybenzaldehyde
-
37°C, pH 7.0
0.0044 - 14.7
2-hydroxypyrimidine
0.0006 - 0.0194
2-Methoxybenzaldehyde
0.0024 - 0.0055
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
0.019
3,4-dimethoxybenzaldehyde
-
37°C, pH 7.0
0.005
3-Hydroxybenzaldehyde
-
37°C, pH 7.0
6.7
3-hydroxypropionaldehyde
-
recombinant cell extract, expression in Klebsiella pneumoniae, pH 7.0, 37°C
0.029
3-Methoxy-4-hydroxybenzaldehyde
-
37°C, pH 7.0
0.0019 - 0.0201
3-Methoxybenzaldehyde
0.0043 - 0.0528
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
0.0004 - 0.0096
4-(dimethylamino)cinnamaldehyde
0.0019 - 0.0346
4-hydroxybenzaldehyde
0.0012 - 0.0234
4-methoxybenzaldehyde
0.0013 - 0.0176
4-nitrobenzaldehyde
0.073 - 0.912
5-nitroquinoline
-
0.027
6-chloroquinazolin-4(3H)-one
-
pH 7.4, 22°C
0.04 - 0.09
6-ethyl-5H-dibenz(c,e)azepine
0.293
6-methoxyquinazolin-4(3H)-one
-
pH 7.4, 22°C
0.142
6-methylquinazolin-4(3H)-one
-
pH 7.4, 22°C
0.2 - 0.3
6-methylthiopurine
0.001 - 0.022
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
0.001 - 0.0086
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
0.0024 - 0.063
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
0.038 - 0.084
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
0.0025 - 52.9
acetaldehyde
0.125
all-trans retinal
-
-
0.031 - 0.07
all-trans retinaldehyde
0.008
all-trans-retinal
-
-
0.00057 - 7.13
benzaldehyde
0.1
butylaldehyde
-
pH 7.0, 30°C
0.0005 - 0.026
Butyraldehyde
0.0074 - 0.012
cinchonidine
0.0012 - 0.0101
cinnamaldehyde
0.1039
cinnamylaldehyde
-
partially purified protein, pH 7.0, 30°C
0.0067
clonazepam
liver cytosol, pH 7.4, 37°C
-
0.052 - 1.03
clothianidin
0.0148 - 1.647
crotonaldehyde
0.02
diphenylsulfoxide
-
as electron acceptor under anaerobic conditions
0.31
DL-glyceraldehyde
-
37°C, pH 7.0
0.0027 - 0.0259
ethyl vanillin
0.03
ferricyanide
-
as electron acceptor under aerobic conditions
0.046
flunitrazepam
liver cytosol, pH 7.4, 37°C
0.053
flutamide
liver cytosol, pH 7.4, 37°C
0.29 - 0.6
Glutaraldehyde
1
glycolaldehyde
-
pH 7.0, 30°C
0.00014 - 1.8
hexylaldehyde
0.0032 - 2.07
Indole-3-acetaldehyde
0.0045 - 0.014
Indole-3-aldehyde
1.8
m-tolualdehyde
-
pH 7.0, 30°C
0.072 - 2.792
methotrexate
0.002
methylene blue
-
as electron acceptor under aerobic conditions
0.73
n-Heptanal
-
pH 7.0, 30°C
0.11
n-Heptylaldehyde
-
37°C, pH 7.0
0.8
n-hexanal
-
pH 7.0, 30°C
0.22
n-hexylaldehyde
-
37°C, pH 7.0
0.08 - 7
N-methylnicotinamide
1.5
n-Pentanal
-
pH 7.0, 30°C
0.18
n-Valeraldehyde
-
37°C, pH 7.0
0.008 - 0.049
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
0.0063
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide
-
pH 7.4 and 37°C
0.0029 - 0.05
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
0.087 - 0.482
N1-methyl-nicotineamide
0.0094 - 0.1285
N1-methylnicotinamide
0.024
NADH
-
in the presence of 1 mM nitrite, at pH 6.0 and 37°C
0.0383
nilutamide
liver cytosol, pH 7.4, 37°C
-
0.2014
nimesulide
liver cytosol, pH 7.4, 37°C
0.0185
nimetazepam
liver cytosol, pH 7.4, 37°C
-
4.8
o-tolualdehyde
-
pH 7.0, 30°C
0.12
O6-benzylguanine
-
pH 7.4, 37°C
0.0026
p-Hydroxybenzaldehyde
-
30°C, pH 7.0
0.0008
p-Methoxybenzaldehyde
-
30°C, pH 7.0
1.4
p-tolualdehyde
-
pH 7.0, 30°C
0.0019 - 0.385
phenanthridine
0.0318 - 0.2797
phenylacetaldehyde
0.0111 - 0.1224
phenylpropionaldehyde
0.0011 - 1.264
Phthalazine
0.0028 - 1.634
propionaldehyde
0.0029 - 0.026
Protocatechualdehyde
0.399
quinazolin-4(3H)-one
-
pH 7.4, 22°C
0.0126 - 0.07
retinalaldehyde
0.0075 - 0.0558
retinaldehyde
0.0035 - 5.2
Salicylaldehyde
1.15
tropylium tetrafluoroborate
-
ferricyanide as electron acceptor
0.0011
Valeraldehyde
-
30°C, pH 7.0
0.0073 - 0.102
zebularine
0.0034
zoniporide
-
in 25 mM phosphate buffer at 37°C, pH not specified in the publication
additional information
additional information
further kinetic parameters of phthalazine-DCPIP reaction in the absence or presence of the inhibitors benzamidine, menadione, norharmane, and raloxifene available in the publication
-
0.0109
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
wild type enzyme, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0157
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R/M1009I/V1010I/R1021V/A1023Y/I1032V/G1064K/I1067M, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0244
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R/M1009I/V1010I/R1021V/A1023Y/I1032V, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0264
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme A1023Y, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.027
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme M1009I, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0334
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme I1032V, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.036
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0366
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0521
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R/M1009I/V1010I, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0965
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme K1004Q/K1005R/M1009I/V1010I/R1021V/A1023Y, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.128
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme A1083T/V1085A, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.131
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta-[d]-pyrimidine
-
mutant enzyme V1085A, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0352
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
mutant enzyme A1081V, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.147
(+)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
wild type enzyme, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0341
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
pH 7.4, 37°C
0.0407
(S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
pH 7.4, 37°C, enzyme isolated from animals fed with a selenium-deficient diet
0.0027
(S)-RS-8359
high affinity component of the expressed enzyme
0.0754
(S)-RS-8359
low affinity component of the expressed enzyme
0.0804
(S)-RS-8359
pH 7.4, 37°C, enzyme from Wistar-Imamichi strain, ratio Vmax/Km 1.98 microl per min and mg
0.0813
(S)-RS-8359
pH 7.4, 37°C, enzyme from Jcl:Wistar strain, ratio Vmax/Km 1.00 microl per min and mg
0.0833
(S)-RS-8359
pH 7.4, 37°C, enzyme from Crj:Wistar strain, ratio Vmax/Km 1.46 microl per min and mg
0.1046
(S)-RS-8359
pH 7.4, 37°C, enzyme from LEW:Crj strain, ratio Vmax/Km 0.58 microl per min and mg
0.14
(S)-RS-8359
pH 7.4, 37°C, enzyme from F344/DuCrj strain, ratio Vmax/Km 0.01 microl per min and mg
0.17
(S)-RS-8359
pH 7.4, 37°C, enzyme from Slc:SD strain, ratio Vmax/Km 0.09 microl per min and mg
0.173
(S)-RS-8359
pH 7.4, 37°C, enzyme from Crj:SD strain, ratio Vmax/Km 0.06 microl per min and mg
0.0021
2,4-dihydroxybenzaldehyde
pH 8, 37°C
0.0145
2,4-dihydroxybenzaldehyde
pH 8, 37°C
0.0263
2,4-dihydroxybenzaldehyde
wild-type, pH 8.0, 37°C
0.2525
2,4-dihydroxybenzaldehyde
pH 8, 37°C
0.57
2-ethylbutylaldehyde
-
37°C, pH 7.0
2.2
2-ethylbutylaldehyde
-
37°C, pH 7.0
3.5
2-ethylbutylaldehyde
-
37°C, pH 7.0
0.0044
2-hydroxypyrimidine
-
-
0.06
2-hydroxypyrimidine
-
25°C, pH 7.4
0.097
2-hydroxypyrimidine
-
apparent Km-value of recombinant mAOX3, pH 7.4, 25°C
0.17
2-hydroxypyrimidine
-
25°C, pH 7.4
0.173
2-hydroxypyrimidine
-
apparent Km-value of native mAOX3, pH 7.4, 25°C
1.65
2-hydroxypyrimidine
-
-
8.3
2-hydroxypyrimidine
-
male enzyme
14.7
2-hydroxypyrimidine
-
female enzyme
0.0006
2-Methoxybenzaldehyde
pH 8, 37°C
0.004
2-Methoxybenzaldehyde
-
37°C, pH 7.0
0.0066
2-Methoxybenzaldehyde
pH 8, 37°C
0.0194
2-Methoxybenzaldehyde
pH 8, 37°C
0.0024
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0026
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0027
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0055
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0019
3-Methoxybenzaldehyde
pH 8, 37°C
0.0084
3-Methoxybenzaldehyde
pH 8, 37°C
0.02
3-Methoxybenzaldehyde
-
37°C, pH 7.0
0.0201
3-Methoxybenzaldehyde
pH 8, 37°C
0.0043
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric rat/monkey enzyme, high affinity value, pH 6.0, 37°C
0.0043
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric rat/monkey enzyme, high affinity value, pH 6.0, 37°C
0.0164
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
wild-type, low affinity value, pH 6.0, 37°C
0.0171
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric rat/monkey enzyme, low affinity value, pH 6.0, 37°C
0.0171
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric rat/monkey enzyme, low affinity value, pH 6.0, 37°C
0.0351
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
wild-type, high affinity value, pH 6.0, 37°C
0.0363
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric monkey/rat enzyme, pH 6.0, 37°C
0.0363
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
chimeric monkey/rat enzyme, pH 6.0, 37°C
0.0528
4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine
-
wild-type, pH 6.0, 37°C
0.0004
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0004
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0005
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0005
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0008
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0008
4-(dimethylamino)cinnamaldehyde
wild-type, pH 8.0, 37°C
0.0033
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0033
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0096
4-(dimethylamino)cinnamaldehyde
-
in the presence of 1 mM nitrite, at pH 6.0 and 37°C
0.0019
4-hydroxybenzaldehyde
wild-type, pH 8.0, 37°C
0.0027
4-hydroxybenzaldehyde
pH 8, 37°C
0.0028
4-hydroxybenzaldehyde
pH 8, 37°C
0.008
4-hydroxybenzaldehyde
-
37°C, pH 7.0
0.0346
4-hydroxybenzaldehyde
pH 8, 37°C
0.0012
4-methoxybenzaldehyde
pH 8, 37°C
0.0118
4-methoxybenzaldehyde
pH 8, 37°C
0.0234
4-methoxybenzaldehyde
pH 8, 37°C
0.0013
4-nitrobenzaldehyde
wild-type, pH 8.0, 37°C
0.0032
4-nitrobenzaldehyde
pH 8, 37°C
0.0105
4-nitrobenzaldehyde
pH 8, 37°C
0.0176
4-nitrobenzaldehyde
pH 8, 37°C
0.073
5-nitroquinoline
metabolite 2-oxo-5-aminoquinoline, pH 7.4, 37°C
-
0.1
5-nitroquinoline
metabolite 5-aminoquinoline, presence of N-(2-(dimethylamino)ethyl)acridine-4-carboxamide, pH 7.4, 37°C
-
0.912
5-nitroquinoline
metabolite 2-oxo-5-nitroquinoline, pH 7.4, 37°C
-
0.912
5-nitroquinoline
metabolite 2-oxo-5-nitroquinoline, presence of N-(2-(dimethylamino)ethyl)acridine-4-carboxamide, pH 7.4, 37°C
-
0.04
6-ethyl-5H-dibenz(c,e)azepine
-
2,6-dichlorophenol-indophenol as electron acceptor in D2O
0.06
6-ethyl-5H-dibenz(c,e)azepine
-
2,6-dichlorophenol-indophenol as electron acceptor in H2O
0.08
6-ethyl-5H-dibenz(c,e)azepine
-
O2 as electron acceptor in H2O
0.09
6-ethyl-5H-dibenz(c,e)azepine
-
O2 as electron acceptor in D2O
0.2
6-methylthiopurine
-
O2 as electron acceptor
0.3
6-methylthiopurine
-
2,6-dichlorophenol indophenol as electron acceptor
0.001
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0017
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0059
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.022
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.001
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0011
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0043
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0086
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0024
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.004
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.02
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.063
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.038
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.064
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.064
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.084
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0025
acetaldehyde
-
30°C, pH 7.0
0.13
acetaldehyde
-
37°C, pH 7.0
0.34
acetaldehyde
-
pH 7.0, 30°C
0.345
acetaldehyde
-
2,6-dichlorophenol-indophenol as electron acceptor
0.5199
acetaldehyde
wild-type, 30°C, pH 7.4
0.8
acetaldehyde
-
25°C, pH 7.4
0.82
acetaldehyde
-
25°C, pH 7.4
1.3
acetaldehyde
-
37°C, pH 7.0
1.4
acetaldehyde
-
37°C, pH 7.0
1.4
acetaldehyde
-
37°C, pH 7.0
3.8
acetaldehyde
-
pH 7.0, 30°C
4.375
acetaldehyde
pH 8, 37°C
4.42
acetaldehyde
pH 8, 37°C
4.596
acetaldehyde
wild-type, pH 8.0, 37°C
18.094
acetaldehyde
pH 8, 37°C
52.9
acetaldehyde
mutant V806E, 30°C, pH 7.4
0.48
acrolein
-
37°C, pH 7.0
0.74
acrolein
-
37°C, pH 7.0
1.4
acrolein
-
37°C, pH 7.0
0.031
all-trans retinaldehyde
-
0.07
all-trans retinaldehyde
-
0.133
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
0.426
allopurinol
mutant P1015G, pH 8.0,37°C
0.527
allopurinol
mutant P1015A, pH 8.0,37°C
1.595
allopurinol
wild-type, pH 8.0,37°C
2.93
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
3.86
allopurinol
mutant F1014V, pH 8.0,37°C
0.00057
benzaldehyde
-
30°C, pH 7.0
0.0008
benzaldehyde
pH 8, 37°C
0.0008
benzaldehyde
mutant M1088V, pH 8.0, 37°C
0.0011
benzaldehyde
mutant I1018S, pH 8.0, 37°C
0.0015
benzaldehyde
-
O2 as electron acceptor
0.0021
benzaldehyde
mutant I1018K, pH 8.0, 37°C
0.0022
benzaldehyde
wild-type, pH 8.0, 37°C
0.0022
benzaldehyde
mutant P1015A, pH 8.0,37°C
0.0023
benzaldehyde
K889H mutant, pH 8.0, 37°C
0.0025
benzaldehyde
mAOX3 wild type, pH 8.0, 37°C
0.0025
benzaldehyde
wild-type, pH 8.0,37°C
0.0029
benzaldehyde
A807V mutant, pH 8.0, 37°C
0.0033
benzaldehyde
mutant P1015G, pH 8.0,37°C
0.004
benzaldehyde
-
25°C, pH 7.4
0.004 - 0.015
benzaldehyde
-
-
0.0046
benzaldehyde
A807V/Y885M double mutant, pH 8.0, 37°C
0.005
benzaldehyde
-
2,6-dichlorophenol-indophenol as electron acceptor
0.0051
benzaldehyde
mutant V1016I, pH 8.0, 37°C
0.0052
benzaldehyde
pH 8, 37°C
0.0063
benzaldehyde
Y885M mutant, pH 8.0, 37°C
0.0064
benzaldehyde
mutant M1088T, pH 8.0, 37°C
0.0103
benzaldehyde
-
pH 7.8, determined according to Eadie-Hofstee
0.0107
benzaldehyde
-
pH 7.8, determined according to Hanes
0.012
benzaldehyde
-
25°C, pH 7.4
0.013
benzaldehyde
-
apparent Km-value of native mAOX3, pH 7.4, 25°C
0.0147
benzaldehyde
-
pH 7.8, determined according to Lineweaver-Burk
0.0165
benzaldehyde
-
pH 7.8, determined according to Eadie-Hofstee
0.0178
benzaldehyde
-
pH 7.8, determined according to Lineweaver-Burk
0.019
benzaldehyde
-
37°C, pH 7.0
0.0191
benzaldehyde
-
pH 7.8, determined according to Hanes
0.0195
benzaldehyde
pH 8, 37°C
0.02
benzaldehyde
-
apparent Km-value of recombinant mAOX3, pH 7.4, 25°C
0.0215
benzaldehyde
mutant F1014V, pH 8.0,37°C
0.0227
benzaldehyde
mutant F1014I, pH 8.0,37°C
0.0238
benzaldehyde
-
partially purified protein, pH 7.0, 30°C
0.0287
benzaldehyde
mutant V1016L, pH 8.0, 37°C
0.039
benzaldehyde
-
female enzyme treated with testosterone propionate
0.04
benzaldehyde
-
male enzyme
0.06
benzaldehyde
-
pH 7.0, 30°C
0.0863
benzaldehyde
E1266Q mutant, pH 8.0, 37°C
0.0977
benzaldehyde
wild-type, 30°C, pH 7.4
0.115
benzaldehyde
-
female enzyme
0.52
benzaldehyde
-
37°C, pH 7.0
0.6345
benzaldehyde
mutant V806E, 30°C, pH 7.4
1.092
benzaldehyde
mutant V1016F, pH 8.0, 37°C
2.2
benzaldehyde
-
pH 7.0, 30°C
2.21
benzaldehyde
mutant F776K/A807E/D878L/L881S/Y885R/P1015T/Y1019L, pH 8.0,37°C
7.13
benzaldehyde
mutant M884R, 30°C, pH 7.4
0.0085
Butanal
pH 8, 37°C
0.026
Butanal
-
apparent Km-value of recombinant mAOX3, pH 7.4, 25°C
0.029
Butanal
-
apparent Km-value of native mAOX3, pH 7.4, 25°C
0.0575
Butanal
wild-type, pH 8.0, 37°C
0.0989
Butanal
pH 8, 37°C
0.0005
Butyraldehyde
-
30°C, pH 7.0
0.008
Butyraldehyde
-
25°C, pH 7.4
0.021
Butyraldehyde
-
25°C, pH 7.4
0.026
Butyraldehyde
-
2,6-dichlorophenol-indophenol as electron acceptor
0.0074
cinchonidine
-
wild type enzyme, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.012
cinchonidine
-
mutant enzyme V1085A, in 80 mM phosphate buffer, pH 7.4, at 37°C
0.0012
cinnamaldehyde
pH 8, 37°C
0.0026
cinnamaldehyde
pH 8, 37°C
0.0101
cinnamaldehyde
pH 8, 37°C
0.06
citral
-
37°C, pH 7.0
0.12
citral
-
37°C, pH 7.0
2.1
citral
-
37°C, pH 7.0
0.052
clothianidin
-
aminoguanidine formation, pH 7.4, 37°C
1.03
clothianidin
-
nitrosoguanidine formation, pH 7.4, 37°C
0.0148
crotonaldehyde
wild-type, pH 8.0, 37°C
0.0848
crotonaldehyde
pH 8, 37°C
0.3806
crotonaldehyde
pH 8, 37°C
1.647
crotonaldehyde
pH 8, 37°C
0.0027
ethyl vanillin
pH 8, 37°C
0.0154
ethyl vanillin
pH 8, 37°C
0.0259
ethyl vanillin
pH 8, 37°C
3.6
formaldehyde
-
37°C, pH 7.0
4.2
formaldehyde
-
37°C, pH 7.0
8.5
formaldehyde
-
37°C, pH 7.0
8.8
formaldehyde
-
pH 7.0, 30°C
21.2
formaldehyde
-
37°C, pH 7.0
29
formaldehyde
-
37°C, pH 7.0
35.9
formaldehyde
-
pH 7.0, 30°C
0.29
Glutaraldehyde
-
37°C, pH 7.0
0.6
Glutaraldehyde
-
pH 7.0, 30°C
0.0097
Glyoxal
-
30°C, pH 7.0
3.8
Glyoxal
-
pH 7.0, 30°C
12.3
Glyoxal
-
pH 7.0, 30°C
0.002
Heptanal
wild-type, pH 8.0, 37°C
0.0039
Heptanal
pH 8, 37°C
0.013
Heptanal
pH 8, 37°C
0.0455
Heptanal
pH 8, 37°C
0.0032
hexanal
wild-type, pH 8.0, 37°C
0.0041
hexanal
pH 8, 37°C
0.0103
hexanal
pH 8, 37°C
0.0392
hexanal
pH 8, 37°C
0.00014
hexylaldehyde
-
30°C, pH 7.0
0.15
hexylaldehyde
-
37°C, pH 7.0
0.26
hexylaldehyde
-
37°C, pH 7.0
1.8
hexylaldehyde
-
37°C, pH 7.0
0.16
imidacloprid
-
aminoguanidine formation, pH 7.4, 37°C
2.99
imidacloprid
-
nitrosoguanidine formation, pH 7.4, 37°C
0.0032
Indole-3-acetaldehyde
-
O2 as electron acceptor
0.005
Indole-3-acetaldehyde
-
2,6-dichlorophenol-indophenol as electron acceptor
0.14
Indole-3-acetaldehyde
pH 8, 25°C
2.07
Indole-3-acetaldehyde
-
partially purified protein, pH 7.0, 30°C
0.0045
Indole-3-aldehyde
-
O2 as electron acceptor
0.014
Indole-3-aldehyde
-
2,6-dichlorophenol-indophenol as electron acceptor
0.072
methotrexate
pH 7.5, 37°C
2.792
methotrexate
pH 7.5, 37°C
0.08
N-methylnicotinamide
-
2,6-dichlorophenol-indophenol as electron acceptor in D2O
0.26
N-methylnicotinamide
-
O2 as electron acceptor in D2O
0.32
N-methylnicotinamide
-
2,6-dichlorophenol-indophenol as electron acceptor in H2O
0.355
N-methylnicotinamide
female rat liver enzyme after reduction with DTT
0.36
N-methylnicotinamide
-
-
0.36
N-methylnicotinamide
male rat liver enzyme after reduction with DTT
0.45
N-methylnicotinamide
-
O2 as electron acceptor in H2O
0.538
N-methylnicotinamide
male rat liver enzyme
0.66
N-methylnicotinamide
-
-
1.063
N-methylnicotinamide
female rat liver enzyme
1.5
N-methylnicotinamide
-
ferricyanide as electron acceptor
1.895
N-methylnicotinamide
female rat liver enzyme after reduction with DTT and reoxidation with 4,4'-dithiodipyridine
7
N-methylnicotinamide
-
-
0.008 - 0.014
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
-
0.011
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
female enzyme treated with testosterone propionate
0.012
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
male enzyme
0.049
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
female enzyme
0.0029
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, strain c129/C57
0.0055
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, nude mouse tumor bearing
0.0074
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, nude mouse
0.027
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, female swiss CD
0.03
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, male swiss CD
0.05
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, strain CB57BI/6J
0.087
N1-methyl-nicotineamide
mutant P1015A, pH 8.0,37°C
0.089
N1-methyl-nicotineamide
mutant P1015G, pH 8.0,37°C
0.128
N1-methyl-nicotineamide
wild-type, pH 8.0,37°C
0.482
N1-methyl-nicotineamide
mutant F1014V, pH 8.0,37°C
0.0094
N1-methylnicotinamide
pH 8, 37°C
0.0255
N1-methylnicotinamide
K889H mutant, pH 8.0, 37°C
0.0279
N1-methylnicotinamide
pH 8, 37°C
0.0359
N1-methylnicotinamide
A807V/Y885M double mutant, pH 8.0, 37°C
0.0827
N1-methylnicotinamide
Y885M mutant, pH 8.0, 37°C
0.1234
N1-methylnicotinamide
A807V mutant, pH 8.0, 37°C
0.1285
N1-methylnicotinamide
mAOX3 wild type, pH 8.0, 37°C
0.084
nitenpyram
-
aminoguanidine formation, pH 7.4, 37°C
2.41
nitenpyram
-
nitrosoguanidine formation, pH 7.4, 37°C
2.7
nitrite
-
in the presence of 0.1 mM NADH, at pH 6.0 and 37°C
3.3
nitrite
-
in the presence of 0.05 mM 4-(dimethylamino)cinnamaldehyde, at pH 6.0 and 37°C
0.0032
octanal
pH 8, 37°C
0.0071
octanal
wild-type, pH 8.0, 37°C
0.0094
octanal
pH 8, 37°C
0.0645
octanal
pH 8, 37°C
0.0134
pentanal
mutant I1018K, pH 8.0, 37°C
0.0134
pentanal
mutant I1018S, pH 8.0, 37°C
0.0157
pentanal
pH 8, 37°C
0.0284
pentanal
mutant M1088V, pH 8.0, 37°C
0.0293
pentanal
mutant V1016I, pH 8.0, 37°C
0.0483
pentanal
wild-type, pH 8.0, 37°C
0.057
pentanal
mutant M1088T, pH 8.0, 37°C
0.0692
pentanal
pH 8, 37°C
0.1356
pentanal
pH 8, 37°C
5.566
pentanal
mutant V1016F, pH 8.0, 37°C
0.0019
phenanthridine
pH 8, 37°C
0.0025
phenanthridine
pH 8, 37°C
0.005
phenanthridine
methanol, pH 7.4, at 35°C
0.00625
phenanthridine
pyridine, pH 7.4, at 35°C
0.0063
phenanthridine
acetonitrile, pH 7.4, at 35°C
0.00666
phenanthridine
dioxane, pH 7.4, at 35°C
0.00769
phenanthridine
2-propanol, pH 7.4, at 35°C
0.00833
phenanthridine
1-propanol, pH 7.4, at 35°C
0.00833
phenanthridine
ethanol, pH 7.4, at 35°C
0.01
phenanthridine
N-N-dimethylformamide, pH 7.4, at 35°C
0.0108
phenanthridine
pH 8, 37°C
0.011
phenanthridine
phosphate buffer, pH 7.4, at 35°C
0.011
phenanthridine
tetrahydrofuran, pH 7.4, at 35°C
0.0118
phenanthridine
A807V/Y885M double mutant, pH 8.0, 37°C
0.0161
phenanthridine
K889H mutant, pH 8.0, 37°C
0.0226
phenanthridine
-
pH 7.0, 25°C
0.032
phenanthridine
wild-type, pH 8.0,37°C
0.0323
phenanthridine
mAOX3 wild type, pH 8.0, 37°C
0.0334
phenanthridine
Y885M mutant, pH 8.0, 37°C
0.047
phenanthridine
mutant P1015G, pH 8.0,37°C
0.073
phenanthridine
mutant F1014I, pH 8.0,37°C
0.099
phenanthridine
mutant P1015A, pH 8.0,37°C
0.1495
phenanthridine
A807V mutant, pH 8.0, 37°C
0.385
phenanthridine
mutant F1014V, pH 8.0,37°C
0.0318
phenylacetaldehyde
wild-type, pH 8.0, 37°C
0.0513
phenylacetaldehyde
pH 8, 37°C
0.1134
phenylacetaldehyde
pH 8, 37°C
0.25
phenylacetaldehyde
-
2,6-dichlorophenol-indophenol as electron acceptor
0.2797
phenylacetaldehyde
pH 8, 37°C
0.0111
phenylpropionaldehyde
wild-type, pH 8.0, 37°C
0.0611
phenylpropionaldehyde
pH 8, 37°C
0.0985
phenylpropionaldehyde
pH 8, 37°C
0.1224
phenylpropionaldehyde
pH 8, 37°C
0.0011
Phthalazine
K889H mutant, pH 8.0, 37°C
0.0013
Phthalazine
recombinant enzyme, pH 7.4, 37°C
0.0014
Phthalazine
mAOX3 wild type, pH 8.0, 37°C
0.0014
Phthalazine
wild-type, pH 8.0,37°C
0.0018
Phthalazine
pH 8, 37°C
0.0021
Phthalazine
pH 8, 37°C
0.0026
Phthalazine
mutant P1015A, pH 8.0,37°C
0.0027
Phthalazine
A807V mutant, pH 8.0, 37°C
0.0029
Phthalazine
A807V/Y885M double mutant, pH 8.0, 37°C
0.0032
Phthalazine
Y885M mutant, pH 8.0, 37°C
0.0033
Phthalazine
mutant M1088V, pH 8.0, 37°C
0.0057
Phthalazine
liver cytosolic fraction, pH 7.4, 37°C
0.0077
Phthalazine
mutant I1018K, pH 8.0, 37°C
0.0083
Phthalazine
wild-type, pH 8.0, 37°C
0.0086
Phthalazine
pH 8, 37°C
0.009
Phthalazine
mutant F1014I, pH 8.0,37°C
0.0094
Phthalazine
mutant M1088T, pH 8.0, 37°C
0.0103
Phthalazine
mutant P1015G, pH 8.0,37°C
0.0106
Phthalazine
mutant V1016I, pH 8.0, 37°C
0.0114
Phthalazine
wild-type, 30°C, pH 7.4
0.0125
Phthalazine
mutant F1014V, pH 8.0,37°C
0.013
Phthalazine
mutant V1016L, pH 8.0, 37°C
0.0285
Phthalazine
mutant V806E, 30°C, pH 7.4
0.059
Phthalazine
mutant I1018S, pH 8.0, 37°C
0.733
Phthalazine
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
1.264
Phthalazine
mutant V1016F, pH 8.0, 37°C
0.0028
propionaldehyde
-
30°C, pH 7.0
0.012
propionaldehyde
-
-
0.074
propionaldehyde
-
2,6-dichlorophenol-indophenol as electron acceptor
0.2264
propionaldehyde
wild-type, pH 8.0, 37°C
0.289
propionaldehyde
pH 8, 37°C
0.2984
propionaldehyde
pH 8, 37°C
0.74
propionaldehyde
-
pH 7.0, 30°C
1.634
propionaldehyde
pH 8, 37°C
0.0029
Protocatechualdehyde
-
O2 as electron acceptor
0.026
Protocatechualdehyde
-
2,6-dichlorophenol-indophenol as electron acceptor
0.22
purine
-
-
12.34
purine
wild-type, pH 8.0, 37°C
0.0038
retinal
-
-
0.0126
retinalaldehyde
pH 8, 37°C
0.0165
retinalaldehyde
pH 8, 37°C
0.0264
retinalaldehyde
pH 8, 37°C
0.03
retinalaldehyde
-
25°C, pH 7.4
0.0321
retinalaldehyde
pH 8, 37°C
0.07
retinalaldehyde
-
25°C, pH 7.4
0.0075
retinaldehyde
mutant M884R, 30°C, pH 7.4
0.0222
retinaldehyde
mutant V806E, 30°C, pH 7.4
0.0558
retinaldehyde
wild-type, 30°C, pH 7.4
0.0035
Salicylaldehyde
pH 8, 37°C
0.0035
Salicylaldehyde
pH 8, 37°C
0.0081
Salicylaldehyde
mutant I1018K, pH 8.0, 37°C
0.0092
Salicylaldehyde
mutant I1018S, pH 8.0, 37°C
0.0132
Salicylaldehyde
pH 8, 37°C
0.0132
Salicylaldehyde
wild-type, pH 8.0, 37°C
0.0136
Salicylaldehyde
mutant M1088V, pH 8.0, 37°C
0.0211
Salicylaldehyde
pH 8, 37°C
0.0211
Salicylaldehyde
pH 8, 37°C
0.0238
Salicylaldehyde
mutant M1088T, pH 8.0, 37°C
0.0447
Salicylaldehyde
mutant V1016I, pH 8.0, 37°C
0.0559
Salicylaldehyde
mutant V1016L, pH 8.0, 37°C
0.07
Salicylaldehyde
-
37°C, pH 7.0
0.0896
Salicylaldehyde
pH 8, 37°C
0.0896
Salicylaldehyde
pH 8, 37°C
0.34
Salicylaldehyde
-
37°C, pH 7.0
0.7
Salicylaldehyde
-
37°C, pH 7.0
3.886
Salicylaldehyde
mutant V1016F, pH 8.0, 37°C
5.2
Salicylaldehyde
-
pH 7.0, 30°C
0.0023
Vanillin
pH 8, 37°C
0.0023
Vanillin
pH 8, 37°C
0.0046
Vanillin
pH 8, 37°C
0.0046
Vanillin
pH 8, 37°C
0.0054
Vanillin
pH 8, 37°C
0.0054
Vanillin
wild-type, pH 8.0, 37°C
0.014
Vanillin
-
pH 7.4, 37°C
0.0158
Vanillin
-
pH 7.4, 37°C, enzyme isolated from animals fed with a selenium-deficient diet
0.104
Vanillin
pH 8, 37°C
0.104
Vanillin
pH 8, 37°C
1.5
Vanillin
-
37°C, pH 7.0
6
Vanillin
-
pH 7.0, 30°C
0.0073
zebularine
-
male, pH 7.5, 37°C
0.0084
zebularine
-
female, pH 7.5, 37°C
0.011
zebularine
-
female, pH 7.5, 37°C
0.011
zebularine
-
male, pH 7.5, 37°C
0.015
zebularine
-
male, pH 7.5, 37°C
0.027
zebularine
-
female, pH 7.5, 37°C
0.102
zebularine
-
male, pH 7.5, 37°C
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