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Literature summary for 1.2.3.1 extracted from

  • Dick, R.A.; Kanne, D.B.; Casida, J.E.
    Substrate specificity of rabbit aldehyde oxidase for nitroguanidine and nitromethylene neonicotinoid insecticides (2006), Chem. Res. Toxicol., 19, 38-43.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.052
-
 clothianidin aminoguanidine formation, pH 7.4, 37°C Rattus norvegicus
0.084
-
 nitenpyram aminoguanidine formation, pH 7.4, 37°C Rattus norvegicus
0.16
-
 imidacloprid aminoguanidine formation, pH 7.4, 37°C Rattus norvegicus
1.03
-
 clothianidin nitrosoguanidine formation, pH 7.4, 37°C Rattus norvegicus
2.41
-
 nitenpyram nitrosoguanidine formation, pH 7.4, 37°C Rattus norvegicus
2.99
-
 imidacloprid nitrosoguanidine formation, pH 7.4, 37°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver partially purified Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
clothianidin + NMNH
-
 Rattus norvegicus nitroso-clothianidin + amino-clothianidin + ?
-
 ?
imidacloprid + NMNH
-
 Rattus norvegicus nitroso-imidacloprid + amino-imidacloprid + ?
-
 ?
additional information a wide variety of xenobiotics may serve as electron acceptors instead of molecular oxygen. Enzyme reduces nitroguanidines to both nitroso- and aminoguanidines, while nitromethylens are reduced only to the corrsponding nitroso metabolites. Reduction of nitroguanidines to amino metabolites depends on enzyme concentration Rattus norvegicus ?
-
 ?
nitenpyram + NMNH
-
 Rattus norvegicus nitroso-nitenpyram + amino-nitenpyram + ?
-
 ?