Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-estradiol | - |
Homo sapiens | |
chlorpromazine | - |
Homo sapiens | |
clozapine | - |
Homo sapiens | |
domperidone | - |
Homo sapiens | |
ethinyl estradiol | - |
Homo sapiens | |
hydralazine | 100 microM reduces enzyme activity by as much as 96% | Homo sapiens | |
menadione | - |
Homo sapiens | |
additional information | addition of 100 microM allopurinol has no significant effect on enzyme activity | Homo sapiens | |
raloxifene | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0063 | - |
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide | pH 7.4 and 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-[(2-dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2 | N-[(2-dimethylamino)ethyl]acridine-4-carboxamide i.e. DACA, an experimental antitumor agent | Homo sapiens | DACA-9(10H)-acridone + H2O2 | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000023 | - |
raloxifene | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.00043 | - |
ethinyl estradiol | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.00047 | - |
menadione | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.00062 | - |
chlorpromazine | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.00087 | - |
beta-estradiol | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.0012 | - |
domperidone | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.0015 | - |
menadione | Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.0036 | - |
ethinyl estradiol | Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.0044 | - |
beta-estradiol | Ki-value for enzyme-substrate complex with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens | |
0.0051 | - |
clozapine | Ki-value for free enzyme with DACA as substrate, assay at 100 microM concentration, pH 7.4 and 37°C | Homo sapiens |