Activating Compound | Comment | Organism | Structure |
---|---|---|---|
hydralazine | stimulation of activity at high and low concentrations | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estradiol | uncompetitive, with no inhibition towards the tested CYP450 enzymes | Homo sapiens | |
quetiapine | additionally shows inhibition towards the major CYP450 enzymes tested | Homo sapiens | |
raloxifene | additionally acts as non-specific inhibitor of all major tested CYP450 enzymes | Homo sapiens |
Organic Solvent | Comment | Organism |
---|---|---|
acetonitrile | inhibitory above 0.5% v/v | Homo sapiens |
DMSO | inhibitory above 0.5% v/v | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00009 | - |
pH 7.4, 37°C | Homo sapiens | raloxifene | |
0.00062 | - |
pH 7.4, 37°C | Homo sapiens | estradiol | |
0.00094 | - |
pH 7.4, 37°C | Homo sapiens | quetiapine |