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Literature summary for 1.2.3.1 extracted from

  • Hamzeh-Mivehroud, M.; Rahmani, S.; Rashidi, M.R.; Hosseinpour Feizi, M.A.; Dastmalchi, S.
    Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids (2013), Xenobiotica, 43, 661-670.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
catechin
-
Rattus norvegicus
daidzein
-
Rattus norvegicus
epicatechin
-
Rattus norvegicus
genistein
-
Rattus norvegicus
hesperetin
-
Rattus norvegicus
hesperidin
-
Rattus norvegicus
hyperoside
-
Rattus norvegicus
menadione standard aldehyde oxidase inhibitor Rattus norvegicus
morin
-
Rattus norvegicus
myricetin
-
Rattus norvegicus
naringenin
-
Rattus norvegicus
quercetin
-
Rattus norvegicus
rutin
-
Rattus norvegicus
silibinin
-
Rattus norvegicus
vitexin
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague–Dawley
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification by heat treatment and ammonium sulfate precipitation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phenanthridine + H2O + O2 inhibitory effects of 15 flavonoids on the activity of rat liver aldehyde oxidase assessed, glycosylated flavonoids show relatively weaker inhibition, quantitative structure–activity relationship studies performed to elucidate the important structural properties responsible for the observed inhibitory effects Rattus norvegicus ?
-
?
phenanthridine + H2O + O2 inhibitory effects of 15 flavonoids on the activity of rat liver aldehyde oxidase assessed, glycosylated flavonoids show relatively weaker inhibition, quantitative structure–activity relationship studies performed to elucidate the important structural properties responsible for the observed inhibitory effects Rattus norvegicus Sprague–Dawley ?
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0037
-
pH 7.0 and 37°C Rattus norvegicus menadione
0.00437
-
pH 7.0 and 37°C Rattus norvegicus quercetin
0.00468
-
pH 7.0 and 37°C Rattus norvegicus genistein
0.0049
-
pH 7.0 and 37°C Rattus norvegicus myricetin
0.00933
-
pH 7.0 and 37°C Rattus norvegicus naringenin
0.0123
-
pH 7.0 and 37°C Rattus norvegicus catechin
0.01585
-
pH 7.0 and 37°C Rattus norvegicus morin
0.0166
-
pH 7.0 and 37°C Rattus norvegicus epicatechin
0.01995
-
pH 7.0 and 37°C Rattus norvegicus hyperoside
0.02042
-
pH 7.0 and 37°C Rattus norvegicus hesperidin
0.02399
-
pH 7.0 and 37°C Rattus norvegicus hesperetin
0.02455
-
pH 7.0 and 37°C Rattus norvegicus daidzein
0.0271
-
pH 7.0 and 37°C Rattus norvegicus rutin
0.03802
-
pH 7.0 and 37°C Rattus norvegicus silibinin
0.0389
-
pH 7.0 and 37°C Rattus norvegicus vitexin