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Literature summary for 1.2.3.1 extracted from
- Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite (2009), J. Biol. Chem., 284, 33850-33858.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| raloxifene | inhibits substrate binding at the molybdenum site of the enzyme | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0096 | - |
4-(dimethylamino)cinnamaldehyde | in the presence of 1 mM nitrite, at pH 6.0 and 37°C | Rattus norvegicus | |
| 0.024 | - |
NADH | in the presence of 1 mM nitrite, at pH 6.0 and 37°C | Rattus norvegicus | |
| 2.7 | - |
nitrite | in the presence of 0.1 mM NADH, at pH 6.0 and 37°C | Rattus norvegicus | |
| 3.3 | - |
nitrite | in the presence of 0.05 mM 4-(dimethylamino)cinnamaldehyde, at pH 6.0 and 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-(dimethylamino)cinnamaldehyde + H2O + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 4-(dimethylamino)cinnamaldehyde + nitrite + H2O + O2 | in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide | Rattus norvegicus | ? + nitric oxide | - |
? | |
| NADH + nitrite + H2O + O2 | in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide. NADH reacts with aldehyde oxidase at the FAD site of the enzyme | Rattus norvegicus | ? + nitric oxide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aldehyde:oxygen oxidoreductase | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
maximum aldehyde oxidase-catalyzed nitric oxide generation occurs at pH 6.0 | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 8 | maximum aldehyde oxidase-catalyzed nitric oxide generation occurs at pH 6.0. When the pH is decreased to 5.0 or increased above 8.0, a decrease in the rate of nitric oxide generation is observed | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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