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Literature summary for 1.2.3.1 extracted from

  • Klecker, R.W.; Cysyk, R.L.; Collins, J.M.
    Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors (2006), Bioorg. Med. Chem., 14, 62-66.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-benzylacyclouridine 50% inhibition at about 0.25 mM Homo sapiens
5-benzylacyclouridine 50% inhibition at about 0.8 mM Macaca fascicularis
5-benzylacyclouridine 50% inhibition at about 0.8 mM Mus musculus
5-benzylacyclouridine 50% inhibition at about 0.3 mM Rattus norvegicus
raloxifene 50% inhibition at about 8 nM Homo sapiens
raloxifene 50% inhibition at about 500 nM Macaca fascicularis
raloxifene 50% inhibition at about 500 nM Mus musculus
raloxifene 50% inhibition above 1100 nM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0073
-
zebularine male, pH 7.5, 37°C Homo sapiens
0.0084
-
zebularine female, pH 7.5, 37°C Homo sapiens
0.011
-
zebularine female, pH 7.5, 37°C Rattus norvegicus
0.011
-
zebularine male, pH 7.5, 37°C Rattus norvegicus
0.015
-
zebularine male, pH 7.5, 37°C Macaca fascicularis
0.027
-
zebularine female, pH 7.5, 37°C Mus musculus
0.102
-
zebularine male, pH 7.5, 37°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Canis lupus familiaris 5829
-
cytosol
-
Macaca fascicularis 5829
-

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
beagle dog
-
Homo sapiens
-
-
-
Macaca fascicularis
-
-
-
Mus musculus
-
-
-
Mus musculus CD-1
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Canis lupus familiaris
-
liver
-
Macaca fascicularis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no substrate: zebularine Canis lupus familiaris ?
-
?
zebularine + H2O + O2
-
Mus musculus uridine + H2O2 major catabolic route for oral antitumor agent zebularine ?
zebularine + H2O + O2
-
Homo sapiens uridine + H2O2 major catabolic route for oral antitumor agent zebularine ?
zebularine + H2O + O2
-
Rattus norvegicus uridine + H2O2 major catabolic route for oral antitumor agent zebularine ?
zebularine + H2O + O2
-
Macaca fascicularis uridine + H2O2 major catabolic route for oral antitumor agent zebularine ?
zebularine + H2O + O2
-
Mus musculus CD-1 uridine + H2O2 major catabolic route for oral antitumor agent zebularine ?