Reference on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Onodera, K.; Moriyama, H.; Takenaka, A.; Tanaka, N.; Akutsu, N.; Muro, M.; Oshima, T.; Imada, K.; Sato, M.; Katsube, Y.
Crystallization and preliminary X-ray studies of a Bacillus subtilis and Thermus thermophilus HB8 chimeric 3-isopropylmalate dehydrogenase
J. Biochem.
109
1-2
1991
Bacillus subtilis, Thermus thermophilus
Manually annotated by BRENDA team
Yamada, T.; Akutsu, N.; Miyazaki, K.; Kakinuma, K.; Yoshida, M.; Oshima, T.
Purification, catalytic properties, and thermal stability of threo-Ds-3-isopropylmalate dehydrogenase coded by leuB gene from an extreme thermophile, Thermus thermophilus strain HB8
J. Biochem.
108
449-456
1990
Thermus thermophilus, Thermus thermophilus HB-8
Manually annotated by BRENDA team
Inagaki, K.; Kawaguchi, H.; Kuwata, Y.; Sugio, T.; Tanaka, H.; Tano, T.
Cloning and expression of the Thiobacillus ferrooxidans 3-isopropylmalate dehydrogenase gene in Escherichia coli
J. Ferment. Bioeng.
70
71-74
1990
Acidithiobacillus ferrooxidans
-
Manually annotated by BRENDA team
Kakinuma, K.; Ozawa, K.; Fujimoto, Y.; Akutsu, N.; Oshima, T.
Stereochemistry of the decarboxylation reaction catalysed by 3-isopropylmalate dehydrogenase from the thermophilic bacterium Thermus thermophilus
J. Chem. Soc. Chem. Commun.
1989
1190-1192
1989
Thermus thermophilus, Thermus thermophilus HB-8
-
Manually annotated by BRENDA team
Kohlhaw, G.B.
beta-Isopropylmalate dehydrogenase from yeast
Methods Enzymol.
166
429-435
1988
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Okumura, H.; Tagami, H.; Fukaya, M.; Masai, H.; Kawamura, Y.; Horinouchi, S.; Beppu, T.
Cloning of the beta-isopropylmalate dehydrogenase gene from Acetobacter aceti and its use for construction of a new host-vector system for Acetobacter
Agric. Biol. Chem.
52
3125-3129
1988
Acetobacter aceti, Acetobacter aceti No 1023
-
Manually annotated by BRENDA team
Katsube, Y.; Tanaka, N.; Takenaka, A.; Yamada, T.; Oshima, T.
Crystallization and preliminary X-ray data for 3-isopropylmalate dehydrogenase of Thermus thermophilus
J. Biochem.
104
679-680
1988
Thermus thermophilus
Manually annotated by BRENDA team
Jenkinson, H.F.; Shep, G.P.; Shepherd, M.G.
Cloning and expression of the 3-isopropylmalate dehydrogenase gene from Candida albicans
FEMS Microbiol. Lett.
49
285-288
1988
Candida albicans
-
Manually annotated by BRENDA team
Hamasawa, K.; Kobayashi, Y.; Harada, S.; Yoda, K.; Yamasaki, M.; Tamura, G.
Molecular cloning and nucleotide sequence of the 3-isopropylmalate dehydrogenase gene of Candida utilis
J. Gen. Microbiol.
133
1089-1097
1987
Cyberlindnera jadinii, Saccharomyces cerevisiae, Thermus thermophilus
Manually annotated by BRENDA team
Sekiguchi, T.; Suda, M.; Sekiguchi, T.; Nosoh, Y.
Cloning and DNA homology of 3-isopropylmalate dehydrogenase genes from thermophilic bacilli
FEMS Microbiol. Lett.
36
41-45
1986
Bacillus caldolyticus, Bacillus caldotenax, Bacillus subtilis, Escherichia coli, Saccharomyces cerevisiae, Thermus thermophilus
-
Manually annotated by BRENDA team
Sekiguchi, T.; Ortega-Cesena, J.; Nosoh, Y.; Ohashi, S.; Tsuda, K.; Kanaya, S.
DNA and amino-acid sequences of 3-isopropylmalate dehydrogenase of Bacillus coagulans. Comparison with the enzymes of Saccharomyces cerevisiae and Thermus thermophilus
Biochim. Biophys. Acta
867
36-44
1986
Bacillus coagulans, Bacillus subtilis, Saccharomyces cerevisiae, Thermus thermophilus
-
Manually annotated by BRENDA team
Urano, N.; Kanayama, H.; Karube, I.
Restriction mapping and partial characterization of beta-isopropylmalate dehydrogenase gene cloned from Citrobacter freundii
J. Biotechnol.
2
39-45
1985
Citrobacter freundii, Citrobacter freundii TIT 01010
-
Manually annotated by BRENDA team
Karube, I.; Urano, N.; Kanayama, H.
Cloning and expression of Citrobacter freundii beta-isopropylmalate dehydrogenase gene in both Escherichia coli and Bacillus subtilis
Appl. Microbiol. Biotechnol.
20
340-343
1984
Citrobacter freundii, Citrobacter freundii TIT 01010
-
Manually annotated by BRENDA team
Sekiguchi, T.; Harada, Y.; Shishido, K.; Nosoh, Y.
Cloning of beta-isopropylmalate dehydrogenase gene from Bacillus coagulans in Escherichia coli and purification and properties of the enzyme
Biochim. Biophys. Acta
788
267-273
1984
Bacillus coagulans
Manually annotated by BRENDA team
Kato, C.; Honda, H.; Kudo, T.; Horikoshi, K.
Molecular cloning and Expression of beta-isopropylmalate dehydrogenase gene from alkalophilic Bacillus in Escherichia coli
J. Ferment. Technol.
62
77-80
1984
Bacillus sp., Bacillus sp. no 38-2
-
Manually annotated by BRENDA team
Ishi, K.; Kudo, T.; Honda, H.; Horikoshi, K.
Molecular cloning of beta-isopropylmalate dehydrogenase gene from Clostridium butyricum M588
Agric. Biol. Chem.
47
2313-2317
1983
Clostridium butyricum, Clostridium butyricum M588
-
Manually annotated by BRENDA team
Tanaka, T.; Kawano, N.; Oshima, T.
Cloning of 3-isopropylmalate dehydrogenase gene of an extreme thermophile and partial purification of the gene product
Biochemistry
89
677-682
1981
Thermus thermophilus, Thermus thermophilus HB-8
Manually annotated by BRENDA team
Hsu, Y.P.; Kohlhaw, G.B.
Leucine biosynthesis in Saccharomyces cerevisiae. Purification and characterization of beta-isopropylmalate dehydrogenase
J. Biol. Chem.
255
7255-7260
1980
Saccharomyces cerevisiae, Saccharomyces cerevisiae SK103
Manually annotated by BRENDA team
Parsons, S.J.; Burns, R.O.
beta-Isopropylmalate dehydrogenase (Salmonella typhimurium)
Methods Enzymol.
17A
793-799
1970
Salmonella enterica subsp. enterica serovar Typhimurium
-
Manually annotated by BRENDA team
Rabin, R.; Urbano, C.; Ajl, S.J.
Isoenzymes of beta-isopropylmalate dehydrogenase from Pseudomonas aeruginosa
Arch. Biochem. Biophys.
134
259-261
1969
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Parsons, S.J.; Burns, R.O.
Purification and properties of beta-isopropylmalate dehydrogenase
J. Biol. Chem.
244
996-1003
1969
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Burns, R.O.; Umbarger, H.E.; Gross, S.R.
The biosythesis of leucine. III. The conversation of alpha-hydroxy-beta-carboxyisocaproate to alpha-ketoisocaproate
Biochemistry
2
1053-1058
1963
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Croft, J.E.; Love, D.R.; Bergquist, P.L.
Expression of leucine genes from an extremely thermophilic bacterium in Escherichia coli
Mol. Gen. Genet.
210
490-497
1987
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Thermus thermophilus, Thermus thermophilus HB-8
Manually annotated by BRENDA team
Wallon, G.; Kryger, G.; Lovett, S.T.; Oshima, T.; Ringe, D.; Petsko, G.A.
Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus
J. Mol. Biol.
266
1016-1031
1997
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Thermus thermophilus
Manually annotated by BRENDA team
Searles, L.L.; Calvo, J.M.
Permeabilized cell and radiochemical assay for beta-isopropylmalate dehydrogenase
Methods Enzymol.
166
225-229
1988
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Dean, A.M.; Dvorak, L.
The role of glutamate 87 in the kinetic mechanism of Thermus thermophilus isopropylmalate dehydrogenase
Protein Sci.
4
2156-2167
1995
Thermus thermophilus
Manually annotated by BRENDA team
Suzuki, T.; Yasugi, M.; Arisaka, F.; Yamagishi, A.; Oshima, T.
Adaptation of a thermophilic enzyme, 3-isopropylmalate dehydrogenase, to low temperatures
Protein Eng.
14
85-91
2001
Thermus thermophilus
Manually annotated by BRENDA team
Aoshima, M.; Oshima, T.
Stabilization of Escherichia coli isopropylmalate dehydrogenase by single amino acid substitution
Protein Eng.
10
249-254
1997
Escherichia coli, Thermus thermophilus
Manually annotated by BRENDA team
Akanuma, S.; Qu, C.; Yamagishi, A.; Tanaka, N.; Oshima, T.
Effect of polar side chains at position 172 on thermal stability of 3-isopropylmalate dehydrogenase from Thermus thermophilus
FEBS Lett.
410
141-144
1997
Thermus thermophilus
Manually annotated by BRENDA team
Chen, R.; Greer, A.; Dean, A.M.
Redesigning secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase
Proc. Natl. Acad. Sci. USA
93
12171-12176
1996
Thermus thermophilus
Manually annotated by BRENDA team
Qu, C.; Akanuma, S.; Tanaka, N.; Moriyama, H.; Oshima, T.
Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus
Acta Crystallogr. Sect. D
57
225-232
2001
Thermus thermophilus
Manually annotated by BRENDA team
Matsunami, H.; Kawaguchi, H.; Inagaki, K.; Eguchi, T.; Kakinuma, K.; Tanaka, H.
Overproduction and substrate specificity of 3-isopropylmalate dehydrogenase from Thiobacillus ferrooxidans
Biosci. Biotechnol. Biochem.
62
372-373
1998
Acidithiobacillus ferrooxidans
Manually annotated by BRENDA team
Yoda, E.; Anraku, Y.; Kirino, H.; Wakagi, T.; Oshima, T.
Purification and characterization of 3-isopropylmalate dehydrogenase from a thermoacidophilic archaebacterium Sulfolobus sp. strain 7
FEMS Microbiol. Lett.
131
243-247
1995
Sulfolobus sp., Sulfolobus sp. 7
Manually annotated by BRENDA team
Kawaguchi, H.; Inagaki, K.; Kuwata, Y.; Tanaka, H.; Tano, T.
3-Isopropylmalate dehydrogenase from chemolithoautotroph Thiobacillus ferrooxidans: DNA sequence, enzyme purification, and characterization
J. Biochem.
114
370-377
1993
Acidithiobacillus ferrooxidans
Manually annotated by BRENDA team
Wallon, G.; Yamamoto, K.; Kirino, H.; Yamagishi, A.; Lovett, S.T.; Petsko, G.A.; Oshima, T.
Purification, catalytic properties and thermostability of 3-isopropylmalate dehydrogenase from Escherichia coli
Biochim. Biophys. Acta
1337
105-112
1997
Escherichia coli, Thermus thermophilus
Manually annotated by BRENDA team
Hurley, J.H.; Dean, A.M.
Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity
Structure
2
1007-1016
1994
Thermus thermophilus
Manually annotated by BRENDA team
Imada, K.; Inagaki, K.; Matsunami, H.; Kawaguchi, H.; Tanaka, H.; Tanaka, N.; Namba, K.
Structure of 3-isopropylmalate dehydrogenase in complex with 3-isopropylmalate at 2.0 A resolution: the role of Glu88 in the unique substrate-recognition mechanism
Structure
6
971-982
1998
Acidithiobacillus ferrooxidans
Manually annotated by BRENDA team
Moriyma, H.; Onodera, K.; Sakurai, M.; Tanaka, N.; Kirino-Kagawa, H.; Oshima, T.; Katsube, Y.
The crystal structures of mutated 3-isopropylmalate dehydrogenase from Thermus thermophilus HB8 and their relationship to the thermostability of the enzyme
J. Biochem.
117(2)
408-413
1995
Thermus thermophilus
-
Manually annotated by BRENDA team
Tsuchiya, D.; Sekiguchi, T.; Takenaka, A.
Crystal structure of 3-isopropylmalate dehydrogenase from the moderate facultative thermophile, Bacillus coagulans: two strategies for thermostabilization of protein structures
J. Biochem.
122
1092-1104
1997
Bacillus coagulans
Manually annotated by BRENDA team
Singh, R.K.; Kefala, G.; Janowski, R.; Mueller-Dieckmann, C.; von Kries, J.P.; Weiss, M.S.
The High-resolution Structure of LeuB (Rv2995c) from Mycobacterium tuberculosis
J. Mol. Biol.
346
1-11
2005
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WKK9), Mycobacterium tuberculosis H37Rv (P9WKK9)
Manually annotated by BRENDA team
Suzuki, T.; Yasugi, M.; Arisaka, F.; Oshima, T.; Yamagishi, A.
Cold-adaptation mechanism of mutant enzymes of 3-isopropylmalate dehydrogenase from Thermus thermophilus
Protein Eng.
15
471-476
2002
Thermus thermophilus
Manually annotated by BRENDA team
Ohkuri, T.; Yamagishi, A.
Increased thermal stability against irreversible inactivation of 3-isopropylmalate dehydrogenase induced by decreased van der Waals volume at the subunit interface
Protein Eng.
16
615-621
2003
Bacillus subtilis
Manually annotated by BRENDA team
Nozawa, A.; Takano, J.; Miwa, K.; Nakagawa, Y.; Fujiwara, T.
Cloning of cDNAs encoding isopropylmalate dehydrogenase from Arabidopsis thaliana and accumulation patterns of their transcripts
Biosci. Biotechnol. Biochem.
69
806-810
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Watanabe, K.; Yamagishi, A.
The effects of multiple ancestral residues on the Thermus thermophilus 3-isopropylmalate dehydrogenase
FEBS Lett.
580
3867-3871
2006
Thermus thermophilus (Q5SIY4), Thermus thermophilus
Manually annotated by BRENDA team
Watanabe, K.; Ohkuri, T.; Yokobori, S.; Yamagishi, A.
Designing thermostable proteins: ancestral mutants of 3-isopropylmalate dehydrogenase designed by using a phylogenetic tree
J. Mol. Biol.
355
664-674
2006
Thermus thermophilus (Q5SIY4), Thermus thermophilus
Manually annotated by BRENDA team
Kalinina, O.V.; Gelfand, M.S.
Amino acid residues that determine functional specificity of NADP- and NAD-dependent isocitrate and isopropylmalate dehydrogenases
Proteins
64
1001-1009
2006
Acidithiobacillus ferrooxidans (Q56268), Agrobacterium tumefaciens (P24404), Arthrospira platensis (Q00412), Aspergillus niger (P87256), Azotobacter vinelandii (P96197), Bacteroides fragilis (P54354), Brassica napus (P29102), Candida boidinii (Q01987), Candida maltosa (P07139), Clostridium pasteurianum (P31958), Cyberlindnera jadinii (P08791), Eremothecium gossypii (O60027), Escherichia coli (P30125), Leptospira interrogans (P24015), Mycobacterium bovis (P94929), Ogataea angusta (P34733), Saccharomyces cerevisiae (P87267), Salmonella enterica subsp. enterica serovar Typhimurium (P37412), Scheffersomyces stipitis (O94114), Thermus aquaticus (P24098), Thermus thermophilus (P61494), Thermus thermophilus (P61495), Zymoseptoria tritici (Q9Y897)
Manually annotated by BRENDA team
Lunzer, M.; Miller, S.P.; Felsheim, R.; Dean, A.M.
The biochemical architecture of an ancient adaptive landscape
Science
310
499-501
2005
Escherichia coli
Manually annotated by BRENDA team
Turakainen, H.; Korhola, M.
Cloning, sequencing and application of the LEU2 gene from the sour dough yeast Candida milleri
Yeast
22
805-812
2005
Candida humilis (Q6PY58), Candida humilis C175/CBS (Q6PY58)
Manually annotated by BRENDA team
Suzuki, T.; Moriyama, H.; Hirose, R.; Sakurai, M.; Tanaka, N.; Oshima, T.
Crystallization and preliminary X-ray studies on the hyperstable 3-isopropylmalate dehydrogenase from the thermoacidophilic archaeon Sulfolobus sp. strain 7
Acta Crystallogr. Sect. D
54
444-445
1998
Sulfolobus sp. 7, Sulfolobus sp.
Manually annotated by BRENDA team
Suzuki, T.; Inoki, Y.; Yamagishi, A.; Iwasaki, T.; Wakagi, T.; Oshima, T.
Molecular and phylogenetic characterization of isopropylmalate dehydrogenase of a thermoacidophilic archaeon, Sulfolobus sp. strain 7
J. Bacteriol.
179
1174-1179
1997
Sulfolobus tokodaii 7 (P50455), Sulfolobus tokodaii (P50455)
Manually annotated by BRENDA team
Drevland, R.M.; Waheed, A.; Graham, D.E.
Enzymology and evolution of the pyruvate pathway to 2-oxobutyrate in Methanocaldococcus jannaschii
J. Bacteriol.
189
4391-4400
2007
Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Lee, C.K.; Cary, S.C.; Murray, A.E.; Daniel, R.M.
Enzymic approach to eurythermalism of Alvinella pompejana and its episymbionts
Appl. Environ. Microbiol.
74
774-782
2008
Alvinella pompejana
Manually annotated by BRENDA team
Graczer, E.; Varga, A.; Hajdu, I.; Melnik, B.; Szilagyi, A.; Semisotnov, G.; Zavodszky, P.; Vas, M.
Rates of unfolding, rather than refolding, determine thermal stabilities of thermophilic, mesophilic, and psychrotrophic 3-isopropylmalate dehydrogenases
Biochemistry
46
11536-11549
2007
Thermus thermophilus (Q5SIY4)
Manually annotated by BRENDA team
Ohkuri, T.; Yamagishi, A.
The effects of mutations at position 253 on the thermostability of the Bacillus subtilis 3-isopropylmalate dehydrogenase subunit interface
J. Biochem.
141
791-797
2007
Bacillus subtilis
Manually annotated by BRENDA team
Graczer, E.; Varga, A.; Melnik, B.; Semisotnov, G.; Zavodszky, P.; Vas, M.
Symmetrical refolding of protein domains and subunits: example of the dimeric two-domain 3-isopropylmalate dehydrogenases
Biochemistry
48
1123-1134
2009
Escherichia coli, Escherichia coli (P30125), Thermus thermophilus (Q5SIY4), Thermus thermophilus, Vibrio sp., Vibrio sp. I5
Manually annotated by BRENDA team
Hajdu, I.; Szilagyi, A.; Kardos, J.; Zavodszky, P.
A link between hinge-bending domain motions and the temperature dependence of catalysis in 3-isopropylmalate dehydrogenase
Biophys. J.
96
5003-5012
2009
Escherichia coli
Manually annotated by BRENDA team
Sasaki, M.; Uno, M.; Akanuma, S.; Yamagishi, A.
Random mutagenesis improves the low-temperature activity of the tetrameric 3-isopropylmalate dehydrogenase from the hyperthermophile Sulfolobus tokodaii
Protein Eng. Des. Sel.
21
721-727
2008
Sulfolobus tokodaii (P50455), Sulfolobus tokodaii
Manually annotated by BRENDA team
Merli, A.; Manikandan, K.; Graczer, E.; Schuldt, L.; Singh, R.K.; Zavodszky, P.; Vas, M.; Weiss, M.S.
Crystallization and preliminary X-ray diffraction analysis of various enzyme-substrate complexes of isopropylmalate dehydrogenase from Thermus thermophilus
Acta Crystallogr. Sect. F
66
738-743
2010
Thermus thermophilus (Q5SIY4), Thermus thermophilus
Manually annotated by BRENDA team
Suzuki, Y.; Asada, K.; Miyazaki, J.; Tomita, T.; Kuzuyama, T.; Nishiyama, M.
Enhancement of latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution
Biochem. J.
431
401-410
2010
Thermus thermophilus (Q72IW9)
Manually annotated by BRENDA team
Nango, E.; Yamamoto, T.; Kumasaka, T.; Eguchi, T.
Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor
Bioorg. Med. Chem.
17
7789-7794
2009
Thermus thermophilus (Q5SIY4), Thermus thermophilus
Manually annotated by BRENDA team
Kasahara, R.; Sato, T.; Tamegai, H.; Kato, C.
Piezo-adapted (2R,3S)-3-isopropylmalate dehydrogenase of the obligate piezophile Shewanella benthica DB21MT-2 isolated from the 11,000-m depth of the Mariana Trench
Biosci. Biotechnol. Biochem.
73
2541-2543
2009
Shewanella benthica (D2YZL2), Shewanella benthica, Shewanella oneidensis
Manually annotated by BRENDA team
Nagae, T.; Kawamura, T.; Chavas, L.M.; Niwa, K.; Hasegawa, M.; Kato, C.; Watanabe, N.
High-pressure-induced water penetration into 3-isopropylmalate dehydrogenase
Acta Crystallogr. Sect. D
68
300-309
2012
Shewanella oneidensis (Q8E9N3)
Manually annotated by BRENDA team
Nagae, T.; Kato, C.; Watanabe, N.
Structural analysis of 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1
Acta Crystallogr. Sect. F
68
265-268
2012
Shewanella benthica (D2YZL2), Shewanella benthica DB21 MT-2 (D2YZL2), Shewanella benthica DB21 MT-2, Shewanella oneidensis (Q8E9N3), Shewanella oneidensis
Manually annotated by BRENDA team
Graczer, E.; Lionne, C.; Zavodszky, P.; Chaloin, L.; Vas, M.
Transient kinetic studies reveal isomerization steps along the kinetic pathway of Thermus thermophilus 3-isopropylmalate dehydrogenase
FEBS J.
280
1764-1772
2013
Thermus thermophilus
Manually annotated by BRENDA team
Graczer, E.; Konarev, P.V.; Szimler, T.; Bacso, A.; Bodonyi, A.; Svergun, D.I.; Zavodszky, P.; Vas, M.
Essential role of the metal-ion in the IPM-assisted domain closure of 3-isopropylmalate dehydrogenase
FEBS Lett.
585
3297-3302
2011
Thermus thermophilus
Manually annotated by BRENDA team
Miyazaki, J.; Nakaya, S.; Suzuki, T.; Tamakoshi, M.; Oshima, T.; Yamagishi, A.
Ancestral residues stabilizing 3-isopropylmalate dehydrogenase of an extreme thermophile: experimental evidence supporting the thermophilic common ancestor hypothesis
J. Biochem.
129
777-782
2001
Sulfolobus tokodaii (P50455), Sulfolobus tokodaii 7 (P50455)
Manually annotated by BRENDA team
He, Y.; Galant, A.; Pang, Q.; Strul, J.; Balogun, S.; Jez, J.; Chen, S.
Structural and functional evolution of isopropylmalate dehydrogenases in the leucine and glucosinolate pathways of Arabidopsis thaliana
J. Biol. Chem.
286
28794-28801
2011
Arabidopsis thaliana, Arabidopsis thaliana (P93832), Arabidopsis thaliana (Q9FMT1), Arabidopsis thaliana (Q9SA14)
Manually annotated by BRENDA team
Graczer, E.; Merli, A.; Singh, R.K.; Karuppasamy, M.; Zavodszky, P.; Weiss, M.S.; Vas, M.
Atomic level description of the domain closure in a dimeric enzyme: Thermus thermophilus 3-isopropylmalate dehydrogenase
Mol. Biosyst.
7
1646-1659
2011
Thermus thermophilus (Q5SIY4), Thermus thermophilus
Manually annotated by BRENDA team
He, Y.; Chen, L.; Zhou, Y.; Mawhinney, T.; Chen, B.; Kang, B.; Hauser, B.; Chen, S.
Functional characterization of Arabidopsis thaliana isopropylmalate dehydrogenases reveals their important roles in gametophyte development
New Phytol.
189
160-175
2011
Arabidopsis thaliana, Arabidopsis thaliana (P93832), Arabidopsis thaliana (Q9FMT1)
Manually annotated by BRENDA team
Graczer, E.; Szimler, T.; Garamszegi, A.; Konarev, P.V.; Labas, A.; Olah, J.; Pallo, A.; Svergun, D.I.; Merli, A.; Zavodszky, P.; Weiss, M.S.; Vas, M.
Dual role of the active site residues of Thermus thermophilus 3-isopropylmalate dehydrogenase: chemical catalysis and domain closure
Biochemistry
55
560-574
2016
Thermus thermophilus (Q5SIY4), Thermus thermophilus
Manually annotated by BRENDA team
Hamajima, Y.; Nagae, T.; Watanabe, N.; Kato-Yamada, Y.; Imai, T.; Kato, C.
Pressure effects on the chimeric 3-isopropylmalate dehydrogenases of the deep-sea piezophilic Shewanella benthica and the atmospheric pressure-adapted Shewanella oneidensis
Biosci. Biotechnol. Biochem.
78
469-471
2014
Shewanella benthica, Shewanella oneidensis
Manually annotated by BRENDA team
Hamajima, Y.; Nagae, T.; Watanabe, N.; Ohmae, E.; Kato-Yamada, Y.; Kato, C.
Pressure adaptation of 3-isopropylmalate dehydrogenase from an extremely piezophilic bacterium is attributed to a single amino acid substitution
Extremophiles
20
177-186
2016
Shewanella benthica, Shewanella benthica DB21MT-2, Shewanella oneidensis (Q8E9N3), Shewanella oneidensis
Manually annotated by BRENDA team
Takahashi, K.; Nakanishi, F.; Tomita, T.; Akiyama, N.; Lassak, K.; Albers, S.V.; Kuzuyama, T.; Nishiyama, M.
Characterization of two ?-decarboxylating dehydrogenases from Sulfolobus acidocaldarius
Extremophiles
20
843-853
2016
Sulfolobus acidocaldarius (Q4JB37), Sulfolobus acidocaldarius, Sulfolobus acidocaldarius MW001 (Q4JB37)
Manually annotated by BRENDA team
Pallo, A.; Olah, J.; Graczer, E.; Merli, A.; Zavodszky, P.; Weiss, M.S.; Vas, M.
Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis
FEBS J.
281
5063-5076
2014
Thermus thermophilus
Manually annotated by BRENDA team
Graczer, E.; Pallo, A.; Olah, J.; Szimler, T.; Konarev, P.V.; Svergun, D.I.; Merli, A.; Zavodszky, P.; Weiss, M.S.; Vas, M.
Glutamate 270 plays an essential role in K+-activation and domain closure of Thermus thermophilus isopropylmalate dehydrogenase
FEBS Lett.
589
240-245
2015
Thermus thermophilus (Q5SIY4), Thermus thermophilus
Manually annotated by BRENDA team
Lee, S.G.; Nwumeh, R.; Jez, J.M.
Structure and mechanism of isopropylmalate dehydrogenase from Arabidopsis thaliana: insights on leucine and aliphatic glucosinolate biosynthesis
J. Biol. Chem.
291
13421-13430
2016
Arabidopsis thaliana, Arabidopsis thaliana (P93882)
Manually annotated by BRENDA team
Sharma, R.; Sastry, G.N.
Deciphering the dynamics of non-covalent interactions affecting thermal stability of a protein: molecular dynamics study on point mutant of Thermus thermophilus isopropylmalate dehydrogenase
PLoS ONE
10
e0144294
2015
Thermus thermophilus (Q5SIY4), Thermus thermophilus
Manually annotated by BRENDA team
He, Y.; Dai, S.; Dufresne, C.; Zhu, N.; Pang, Q.; Chen, S.
Integrated proteomics and metabolomics of Arabidopsis acclimation to gene-dosage dependent perturbation of isopropylmalate dehydrogenases
PLoS ONE
8
e57118
2013
Arabidopsis thaliana (P93832), Arabidopsis thaliana (Q9FMT1), Arabidopsis thaliana (Q9SA14)
Manually annotated by BRENDA team