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Literature summary for 1.1.1.85 extracted from

  • Sharma, R.; Sastry, G.N.
    Deciphering the dynamics of non-covalent interactions affecting thermal stability of a protein: molecular dynamics study on point mutant of Thermus thermophilus isopropylmalate dehydrogenase (2015), PLoS ONE, 10, e0144294.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A172L the mutant shows improved thermal stability compared to the wild type enzyme Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2R,3S)-3-isopropylmalate + NAD+ Thermus thermophilus
-
(2S)-2-isopropyl-3-oxosuccinate + NADH + H+
-
?
(2R,3S)-3-isopropylmalate + NAD+ Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
(2S)-2-isopropyl-3-oxosuccinate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Thermus thermophilus Q5SIY4
-
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579 Q5SIY4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R,3S)-3-isopropylmalate + NAD+
-
Thermus thermophilus (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
-
?
(2R,3S)-3-isopropylmalate + NAD+
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
IPMDH
-
Thermus thermophilus
isopropylmalate dehydrogenase
-
Thermus thermophilus
leuB
-
Thermus thermophilus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Thermus thermophilus