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Literature summary for 1.1.1.85 extracted from

  • Hurley, J.H.; Dean, A.M.
    Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity (1994), Structure, 2, 1007-1016.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with NAD+ Thermus thermophilus

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R,3S)-3-isopropylmalate + NAD+
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Thermus thermophilus 2-oxoisocaproate + NADH + H+ + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ NAD+ binding induces a conformational transition in IMDH Thermus thermophilus