6.4.1.2: acetyl-CoA carboxylase
This is an abbreviated version!
For detailed information about acetyl-CoA carboxylase, go to the full flat file.
Word Map on EC 6.4.1.2
-
6.4.1.2
-
amp-activated
-
triglyceride
-
lipogenesis
-
adipose
-
lipogenic
-
sterol
-
peroxisome
-
cholesterol
-
obesity
-
carnitine
-
malonyl-coa
-
proliferator-activated
-
high-fat
-
adipocytes
-
lipoprotein
-
element-binding
-
biotin
-
steatosis
-
lipase
-
obese
-
herbicide
-
srebp-1c
-
triacylglycerols
-
diet-induced
-
stearoyl-coa
-
malic
-
adiponectin
-
nafld
-
lipolysis
-
monophosphate-activated
-
hfd-induced
-
protein-1c
-
weed
-
carboxylases
-
aicar
-
atp-citrate
-
malonyl
-
desaturase-1
-
anti-obesity
-
biotin-dependent
-
hormone-sensitive
-
chrebp
-
5'-amp-activated
-
palmitoyltransferase-1
-
target-site
-
adenoid
-
srebf1
-
anti-adipogenic
-
lolium
-
biotechnology
-
medicine
-
herbicide-resistant
-
pharmacology
-
synthesis
-
drug development
-
biofuel production
-
agriculture
- 6.4.1.2
-
amp-activated
- triglyceride
-
lipogenesis
- adipose
-
lipogenic
- sterol
- peroxisome
- cholesterol
- obesity
- carnitine
- malonyl-coa
-
proliferator-activated
-
high-fat
- adipocytes
- lipoprotein
-
element-binding
- biotin
- steatosis
- lipase
-
obese
-
herbicide
- srebp-1c
- triacylglycerols
-
diet-induced
- stearoyl-coa
-
malic
- adiponectin
- nafld
-
lipolysis
-
monophosphate-activated
-
hfd-induced
- protein-1c
-
weed
- carboxylases
- aicar
-
atp-citrate
-
malonyl
-
desaturase-1
-
anti-obesity
-
biotin-dependent
-
hormone-sensitive
-
chrebp
-
5'-amp-activated
-
palmitoyltransferase-1
-
target-site
- adenoid
-
srebf1
-
anti-adipogenic
- lolium
- biotechnology
- medicine
-
herbicide-resistant
- pharmacology
- synthesis
- drug development
- biofuel production
- agriculture
Reaction
Synonyms
ACACA, ACACB, ACC, ACC-1, ACC-2, ACC1, Acc1a, Acc1b, Acc1p, ACC2, AccA, ACCalpha, ACCase, ACCase 1, ACCB, AccC, Acetyl CoA carboxylase, Acetyl coenzyme A carboxylase, acetyl coenzyme A carboxylase alpha, acetyl-CoA carboxylase, acetyl-CoA carboxylase 1, acetyl-CoA carboxylase 2, acetyl-CoA carboxylase A, acetyl-CoA carboxylase alpha, acetyl-CoA carboxylase B, acetyl-CoA carboxylase-2, acetyl-CoA carboxylase-alpha, acetyl-CoA-carboxylase, acetyl-CoA/propionyl-CoA carboxylase, Acetyl-coenzyme A carboxylase, acetyl-coenzyme-A carboxylase, acetylCoA carboxylase, acyl coenzyme A carboxylase, acyl-CoA carboxylase, BCCP1, BCCP2, CAC1A, CAC1B, Carboxylase, acetyl coenzyme A, Hfa1p, More, PccB
ECTree
6.4.1.2 acetyl-CoA carboxylaseAdvanced search results
results (
results (IC50 Value
IC50 Value on EC 6.4.1.2 - acetyl-CoA carboxylase
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IC50 VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.00029
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000157
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000155
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000248
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000869
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000434
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000842
(2-[(1E,3Z)-hexa-1,3,5-trien-1-yl]quinolin-4-yl)(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.000178 - 0.001028
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
0.000789 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
0.000071 - 0.00191
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
0.00258 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
0.000273 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
0.00183 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
0.000246 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
0.000335 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
0.000486 - 0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
0.000227 - 0.00936
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
0.000355 - 0.01
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
0.000231 - 0.00393
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
0.000244 - 0.000688
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000037 - 0.00457
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000258 - 0.00909
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.000159 - 0.00921
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
0.00891
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)(quinolin-4-yl)methanone
Rattus norvegicus
-
ACC1
0.00301
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-3-yl)phenyl]methanone
Rattus norvegicus
-
ACC1
0.00127
(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)[3-(1H-pyrazol-4-yl)phenyl]methanone
Rattus norvegicus
-
ACC1
0.000075
(4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000004 - 0.000091
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
0.000037 - 0.00054
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
0.001 - 0.00162
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
0.000163 - 0.0004
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.001 - 0.00132
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.000562
1'-(1H-indazol-7-ylcarbonyl)-6-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000634 - 0.000641
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
0.00253
1'-(1H-indazol-7-ylcarbonyl)-7-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00085
1'-(1H-indazol-7-ylcarbonyl)-7-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00221
1'-(1H-indazol-7-ylcarbonyl)-7-phenylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000055
1'-(anthracen-9-ylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine
Mus musculus
-
ACC1 and ACC2
0.000006
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000014
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(2-oxopyrrolidin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000027
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-(4-methylpiperazin-1-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000002
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-methyl-6-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000026
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-morpholin-4-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000036
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-piperidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000061
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-7-pyrrolidin-1-ylspiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.0012
1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000303
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]-6-carboxylic acid
Rattus norvegicus
-
ACC1
0.0000061 - 0.000031
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000075
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0000045 - 0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000074
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019 - 0.00003
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000017 - 0.000039
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000076 - 0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000031
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000062
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-fluoro-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000027
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methoxy-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000058 - 0.000098
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
0.000045
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000041
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[2,3-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000012
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-b]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000117
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]thieno[3,2-c]pyridin-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000038
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([6-chloro-2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00000058
1-((2S)-1-((2-(4-(3-(cyclopropylmethoxy)phenoxy)phenyl)-1,3-oxazol-5-yl)oxy)propan-2-yl)urea
Homo sapiens
pH 7.5, 22°C
0.00017 - 0.00033
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000022 - 0.000051
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000043 - 0.000075
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000048 - 0.000087
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.00013 - 0.00023
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.0002 - 0.00036
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.0000049 - 0.000021
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
0.0000061 - 0.000025
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
0.0000059 - 0.000022
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
0.001864
1-(3-[[4-(1-acetylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000242
1-(3-[[4-(1-butanoylpiperidin-4-yl)piperazin-1-yl]-carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0000081 - 0.000041
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.000043 - 0.00041
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00002 - 0.00012
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000023 - 0.00035
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000014 - 0.000078
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000016 - 0.00011
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
0.000027 - 0.00015
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
0.000049 - 0.00029
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000075 - 0.0003
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000131
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000184
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000052
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000068
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000076
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000102
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone
Homo sapiens
-
ACC1/2
0.000169
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone
Homo sapiens
-
ACC1/2
0.000126
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
ACC1/2
0.000115
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one
Homo sapiens
-
ACC1/2
0.000076
1-(4-[[4-(4-[[2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000117
1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000127
1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000069
1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000042
1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000057
1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000032
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000037
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000021
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00003
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000055
1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000033
1-(4-[[4-(4-[[2-(2,3-dimethyl-1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000033
1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000059
1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00003
1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000169
1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000061
1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000049
1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000033
1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000036
1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000048
1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000105
1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000166 - 0.000492
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
0.000391 - 0.00401
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
0.000037 - 0.00015
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
0.000079 - 0.00065
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000207
1-ethyl-3-(3-[[4-(1-pentanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000597
1-ethyl-3-(3-[[4-(1-propanoylpiperidin-4-yl)piperazin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032 - 0.00023
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000033 - 0.00035
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000064 - 0.00051
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000051 - 0.00036
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000022 - 0.00028
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.00004 - 0.00019
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
0.000131
1-ethyl-3-[3-([4-[1-(2-methylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000144
1-ethyl-3-[3-([4-[1-(3-methylbutanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000015 - 0.000076
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000009 - 0.000093
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
0.000017
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]-piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
1-fluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate hydrochloride
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000018 - 0.00012
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000012 - 0.00002
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.000249
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000766
1-[(3-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000045 - 0.00003
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.0000246
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-6'-(1-methyl-1H-pyrazol-4-yl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000154
1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000085 - 0.00016
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000013 - 0.000063
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
0.0000044 - 0.000048
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
0.000015 - 0.00016
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000109
1-[3-([4-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000081
1-[3-([4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000049
1-[3-([4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea maleate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000017 - 0.00015
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
0.000017 - 0.00008
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
0.000074
1-[3-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
ACC1/2
0.0001
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000072
1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000047
1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000027
1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00007
1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000042
1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.0000084
1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.00338
1H-indazol-7-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.001
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00013
2,2-dimethylpropyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.038 - 0.054
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
0.0025 - 0.0057
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.000073
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
Homo sapiens
-
ACC1/2
0.0035 - 0.017
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
0.000067
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide
Homo sapiens
-
ACC1/2
0.00075 - 0.0029
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
0.01
4-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-1-(4-propoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000169
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.000095
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.000151
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide
Homo sapiens
-
ACC1/2
0.00008
4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000023 - 0.000098
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.000061
5'-ethoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000086
5'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000034 - 0.000048
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
0.0011
5-(tetradecyloxy)-2-furoyl-CoA
Rattus norvegicus
-
pH 7.5, 37°C, partially purified native enzyme
0.0009 - 0.0046
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
0.0018 - 0.028
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000012 - 0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000019 - 0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000051 - 0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.0000065 - 0.000104
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000026
5-methoxy-1'-{[2-(pyridin-2-yl)-1H-benzimidazol-6-yl]carbonyl}spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000016 - 0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
0.000011 - 0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
0.0035 - 0.0043
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
0.000054
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.0000097
5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
Homo sapiens
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication
0.000975
6'-(1-methyl-1H-pyrazol-4-yl)-1-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-6-yl]carbonyl)spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.00135
6'-amino-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000182
6'-methoxy-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[2,3-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000366
6'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-b]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000036
6,7-dimethyl-1'-[(3-methyl-1H-indazol-6-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000022 - 0.000048
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000236
6-(2-oxopyrrolidin-1-yl)-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.0000064 - 0.000013
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
0.00183
6-chloro-1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00139 - 0.00213
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
0.000001 - 0.00005
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
0.000099
6-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000059
7-(3,5-dimethylmorpholin-4-yl)-1'-[(2,6-diphenylpyridin-4-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.000208
7-morpholin-4-yl-1'-(10H-phenoxazin-10-ylcarbonyl)-1H-spiro[naphthalene-2,4'-piperidin]-4(3H)-one
Mus musculus
-
-
0.00006
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000325
anthracen-9-yl(4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl)methanone
Rattus norvegicus
-
ACC1
0.000091
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000095
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000161
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000239
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000121
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.00007 - 0.00091
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
0.000076
cyclohexyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000244
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone
Homo sapiens
-
ACC1/2
0.000052
cyclopentyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000055
ethyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0014 - 0.008
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
0.000102
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
Homo sapiens
-
ACC1/2
0.000175
methyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00025 - 0.0039
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
0.00162
methyl [4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetate
Homo sapiens
-
isozyme ACC2
0.00616
N-(1-methyl-3-[2-[2-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000018
N-(1-methyl-3-[2-[2-methyl-3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000009
N-(1-methyl-3-[2-[2-methyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000014
N-(1-methyl-3-[2-[3-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000013
N-(1-methyl-3-[2-[3-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00021
N-(1-methyl-3-[2-[3-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00013
N-(1-methyl-3-[2-[3-(trifluoromethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00038
N-(1-methyl-3-[2-[3-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00029
N-(1-methyl-3-[2-[4-(1,3-thiazolidin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.0000044 - 0.00019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.00007
N-(1-methyl-3-[2-[4-(2-methylpropoxy)-2-nitrophenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00001
N-(1-methyl-3-[2-[4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00081
N-(1-methyl-3-[2-[4-(2-methylpropyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000057
N-(1-methyl-3-[2-[4-(pyridin-2-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000067
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00037
N-(1-methyl-3-[2-[4-(tetrahydrofuran-3-yloxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00035 - 0.01948
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
0.000054 - 0.000193
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
0.000036 - 0.000609
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
0.000348 - 0.000811
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
0.000061
N-(3-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]-1-methylprop-2-yn-1-yl)acetamide
Mus musculus
-
-
0.001
N-(3-[2-[2-(hydroxymethyl)-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.0158
N-(3-[2-[2-amino-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000035
N-(3-[2-[2-bromo-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000069
N-(3-[2-[2-chloro-4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000012
N-(3-[2-[2-chloro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000029
N-(3-[2-[2-chloro-4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000019
N-(3-[2-[2-chloro-4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000034
N-(3-[2-[2-chloro-4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00014
N-(3-[2-[2-chloro-4-(tetrahydrofuran-3-ylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000042
N-(3-[2-[2-cyano-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000011
N-(3-[2-[2-fluoro-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00055
N-(3-[2-[2-formyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00026
N-(3-[2-[2-vinyl-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000026
N-(3-[2-[3-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000027
N-(3-[2-[4-(cyclohexylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000016
N-(3-[2-[4-(cyclohexyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000005 - 0.000027
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
0.000013
N-(3-[2-[4-(cyclopentyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000007
N-(3-[2-[4-(cyclopropylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000016
N-(3-[2-[4-(cyclopropyloxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00063 - 0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
0.03
N-(3-[cis-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019 - 0.013
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
0.000259 - 0.01
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
0.000013
N-3-[2-[2-chloro-(4-propoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000119
N-tert-butyl-4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxamide
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00004 - 0.000724
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
0.000024 - 0.000386
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
0.03
N-[(2R)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0078 - 0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00006 - 0.0105
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
0.0002 - 0.00675
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
0.000015 - 0.00114
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
0.00008 - 0.0008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.00006 - 0.01
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
0.000006
N-[1'-[(2,6-diphenylpyridin-4-yl)carbonyl]-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidin]-6-yl]butanamide
Mus musculus
-
-
0.00014 - 0.000268
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
0.00196
N-[1-methyl-3-(2-phenoxy-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00015
N-[1-methyl-3-(2-[4-[(1-methylethyl)amino]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00055
N-[1-methyl-3-(2-[4-[(1-methylethyl)sulfanyl]phenoxy]-1,3-thiazol-5-yl)prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000076
N-[1-methyl-3-[2-(3-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00011
N-[1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000004
N-[1-methyl-3-[2-(4-propoxyphenoxy)-1,3-thiazol-5-yl]prop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00405
N-[3-(2-[4-[(ethylperoxy)sulfanyl]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-(2-[4-[3-(dimethylamino)propoxy]phenoxy]-1,3-thiazol-5-yl)-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00007 - 0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
0.00131
N-[3-[2-(2-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00132
N-[3-[2-(2-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-(3,4-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-(3,5-dimethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00085
N-[3-[2-(3-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.000037
N-[3-[2-(4-ethoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.0017
N-[3-[2-(4-hydroxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00047
N-[3-[2-(4-methoxyphenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00034
N-[3-[2-(4-[[(ethylamino)oxy]methoxy]phenoxy)-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-[2-[(dimethylamino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00057
N-[3-[2-[2-[(E)-(hydroxyimino)methyl]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.03
N-[3-[2-[2-[(methoxymethyl)amino]-4-(2-methylpropoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl]acetamide
Homo sapiens
-
isozyme ACC2
0.00019 - 0.0032
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
0.000101
N-[4-oxo-1'-(10H-phenoxazin-10-ylcarbonyl)-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidin]-6-yl]butanamide
Mus musculus
-
-
0.00015
PII protein
Arabidopsis thaliana
-
apparent value, in 100 mM Tricine (pH 8.2), at 30°C
-
0.000411
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate
Homo sapiens
-
ACC1/2
0.000028
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000032
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-5-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate maleate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00006
propan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0029
tert-butyl ([trans-4-[([[2-(3,5-dimethylisoxazol-4-yl)-quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000099 - 0.001
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
0.000024
tert-butyl 4-[4-([2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl]carbonyl)piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.0025
tert-butyl [(4-[[(naphthalen-2-ylsulfonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00078
tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]-pyridine-4-carboxamido)methyl)cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00057 - 0.0023
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
0.0058 - 0.0083
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
0.0045 - 0.0066
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00024
tert-butyl [(trans-4-[[([2-[3-(aminomethyl)phenyl]-quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000089 - 0.00078
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00073 - 0.0053
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00023 - 0.0023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.0017
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)phenyl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate acetate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00069 - 0.0043
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
0.00033
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.001
tert-butyl [[cis-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0038
tert-butyl [[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00021
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00069
tert-butyl [[trans-4-([[(2-phenylquinolin-4-yl)sulfonothioyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0013 - 0.013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00021
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0011
tert-butyl [[trans-4-([[(2-pyridin-4-ylquinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00024 - 0.0013
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.000052
tert-butyl [[trans-4-([[(2-[3-(aminomethyl)phenyl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00063 - 0.0045
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.00011 - 0.0012
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
0.01
tert-butyl[[trans-4-([[(2-chloroquinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00068
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0063
tetrahydro-2H-pyran-4-yl [[trans-4-([[(2-[4-[2-(di-methylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0036
[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl](2-phenylquinolin-4-yl)methanone
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000693
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone
Homo sapiens
-
ACC1/2
0.03
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetic acid
Homo sapiens
-
isozyme ACC2
0.0265
[4-([5-[3-(acetylamino)but-1-yn-1-yl]-1,3-thiazol-2-yl]oxy)phenoxy]acetyl methylcarbamate
Homo sapiens
-
isozyme ACC2
0.0099
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)-cyclohexyl]methyltert-butylcarbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0017
[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyltert-butylcarbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.000178
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.001028
(2R)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000789
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-phenoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000071
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00191
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00258
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-(4-propoxyphenyl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000273
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(propan-2-yloxy)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.00183
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[2-methyl-4-(trifluoromethoxy)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000246
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methyl-4-[4-propoxy-2-(trifluoromethyl)phenyl]piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000335
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(propan-2-yl)piperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000486
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(4-methoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000227
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00936
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000355
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.01
(2S)-1-[5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl]-4-(5-ethoxy-3-methylpyridin-2-yl)-2-methylpiperazine
Homo sapiens
value above, pH and temperature not specified in the publication
0.000231
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00393
(2S)-2-ethyl-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000244
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000688
(2S)-4-(2-chloro-4-propoxyphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000037
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00457
(2S)-4-(4-ethoxy-2-methylphenyl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000258
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00909
(2S)-4-(5-ethoxy-3-methylpyridin-2-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000159
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.00921
(2S)-4-(6-ethoxy-4-methylpyridin-3-yl)-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylpiperazine
Homo sapiens
pH and temperature not specified in the publication
0.000004
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 4 nM
0.000011
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the wild-type enzyme in crude extract 11 nM
0.000091
(E)-3-benzo[1,3]dioxol-5-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 91 nM
0.000037
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 37 nM
0.000288
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Escherichia coli
-
, for IC50 for the wild-type enzyme in crude extract 288 nM
0.00054
(E)-3-biphenyl-4-yl-N-[(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-acrylamide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 540 nM
0.001
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
above, ACC2
0.00162
1'-(1H-indazol-7-ylcarbonyl)-5-methoxyspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000163
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0004
1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.001
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
above, ACC2
0.00132
1'-(1H-indazol-7-ylcarbonyl)-6,8-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000634
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000641
1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000061
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000031
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.0000045
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00003
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-4-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000017
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000039
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(2-methyl-1,3-oxazol-5-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000076
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000018
1'-[(7-methyl-1H-indazol-5-yl)carbonyl]-6-(5-methyl-1H-pyrazol-3-yl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000058
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.000098
1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-([2-[(ethylcarbamoyl)amino]-6-methyl-1-benzothiophen-3-yl]carbonyl)-piperazin-1-yl]piperidine-1-carboxylate
Homo sapiens
-
in 60.6 mM Tris acetate, pH 7.5, 0.00132 mM beta-mercaptoethanol, 5 mM magnesium acetate, 8 mM magnesium sulfate, 10 mM sodium citrate and 1 mg/ml bovine serum albumin, at 37°C
0.00017
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00033
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000051
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000043
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000075
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000048
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000087
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.00013
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00023
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0002
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.00036
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000049
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000021
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000061
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000025
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000059
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.0000081
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000041
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000043
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00041
1-(3-[[4-(2,3-diethyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00002
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00012
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000023
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00035
1-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000014
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000078
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-6-methylthieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000016
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00011
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000027
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-(3-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[3,2-b]pyridin-2-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000049
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00029
1-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000075
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.0003
1-(3-[[4-(3-ethyl-2-methyl-4-oxo-1,3,7-triazaspiro[4.5]dec-1-en-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000166
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000492
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)-2-(trifluoromethyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000391
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.00401
1-(5-ethyl-1,2,4-oxadiazol-3-yl)-4-(2-methyl-4-propoxyphenyl)piperazine
Homo sapiens
pH and temperature not specified in the publication
0.000037
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-(7-[[4-(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]thieno[2,3-b]pyrazin-6-yl)-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000079
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00065
1-ethyl-3-(3-[[4-(1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000032
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00023
1-ethyl-3-(3-[[4-(2-ethyl-1,3-dioxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000033
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00035
1-ethyl-3-(3-[[4-(2-ethyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000064
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00051
1-ethyl-3-(3-[[4-(2-methyl-1-oxo-2,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000051
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00036
1-ethyl-3-(3-[[4-(3-ethyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000022
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00028
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00004
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.00019
1-ethyl-3-(3-[[4-(3-ethyl-2,4-dioxo-1-oxa-3,7-diazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000015
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000076
1-ethyl-3-[6-ethyl-3-([4-[2-methyl-4-oxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000009
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000093
1-ethyl-3-[6-methyl-3-([4-[(5S)-1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)thieno[2,3-b]pyridin-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000018
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00012
1-methyl-3-[3-([4-[1-oxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000012
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.00002
1-[(3,7-dimethyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.0000045
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.00003
1-[(7-methyl-1H-indazol-5-yl)carbonyl]-5'-(propan-2-yloxy)spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.0000085
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00016
1-[3-([4-[(5S)-1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000013
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000063
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.0000044
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000048
1-[3-([4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-methylthieno[2,3-b]pyridin-2-yl]-3-methylurea
Homo sapiens
pH and temperature not specified in the publication
0.000015
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00016
1-[3-([4-[1,3-dioxo-2-(propan-2-yl)-2,7-diazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000017
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-[3-([4-[2,4-dioxo-3-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-7-yl]piperidin-1-yl]carbonyl)-6-ethylthieno[2,3-b]pyridin-2-yl]-3-ethylurea
Homo sapiens
pH and temperature not specified in the publication
0.000017
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00008
1-[3-([4-[3-ethyl-4-oxo-2-(propan-2-yl)-1,3,7-triazaspiro[4.5]dec-1-en-7-yl]piperidin-1-yl]carbonyl)-1-benzothiophen-2-yl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00015
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.003
1-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]urea
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.051
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
Setaria viridis
-
IC50 is 0.051 mM for the herbicide-sensitive biotype and 0.067 mM for the herbicide-resistant biotype
0.076
2,6,6-trimethyl-4-(2,4,6-trimethyl-phenyl)-[1,2]oxazinane-3,5-dione
Eleusine indica
-
IC50 is 0.076 mM for the herbicide-sensitive biotype and 0.227 mM for the herbicide-resistant biotype
0.00184
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.00206
2-hydroxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000718
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC2
0.000753
2-methoxy-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)acetamide
Homo sapiens
-
ACC1
0.000188
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC1
0.000214
2-methyl-N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)propanamide
Homo sapiens
-
ACC2
0.038
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.038 mM for the herbicide-sensitive biotype and 0.407 mM for the herbicide-resistant biotype
0.054
2-[1-[(E)-allyloxyimino]-propyl]-5-(2-ethylsulfanyl-propyl)-3-hydroxy-4-methoxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.054 mM for the herbicide-sensitive biotype and above 0.10 mM for the herbicide-resistant biotype
0.0025
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0025 mM for the herbicide-sensitive biotype and 0.038 mM for the herbicide-resistant biotype
0.0057
2-[1-[(E)-allyloxyimino]-propyl]-5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.0057 mM for the herbicide-sensitive biotype and 0.0058 mM for the herbicide-resistant biotype
0.0035
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.024 mM for the herbicide-resistant biotype
0.017
3-hydroxy-5,5-dimethyl-2-[2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl]-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.017 mM for the herbicide-sensitive biotype and 0.016 mM for the herbicide-resistant biotype
0.00075
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0029
4-(4-[[(trans-4-[[(tert-butoxycarbonyl)amino]methyl]-cyclohexyl)methyl]carbamoyl]quinolin-2-yl)benzoic acid
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000023
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000098
5'-(butan-2-yloxy)-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.000034
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Rattus norvegicus
-
ACC1
0.000048
5'-methoxy-7'-methyl-1-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[piperidine-4,2'-pyrano[3,2-c]pyridin]-4'(3'H)-one
Homo sapiens
-
ACC2
0.000126
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.00146
5-ethyl-3-(2'-methyl-4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.000841
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.00428
5-ethyl-3-(4'-propoxybiphenyl-4-yl)-1,2,4-oxadiazole
Homo sapiens
pH and temperature not specified in the publication
0.0009
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
Setaria viridis
-
IC50 is 0.0009 mM for the herbicide-sensitive biotype and 0.008 mM for the herbicide-resistant biotype
0.0046
5-hydroxy-2,6,6-trimethyl-4-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-propionyl-6H-[1,2]oxazin-3-one
Eleusine indica
-
IC50 is 0.0046 mM for the herbicide-sensitive biotype and 0.0078 mM for the herbicide-resistant biotype
0.0018
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
Setaria viridis
-
IC50 is 0.0018 mM for the herbicide-sensitive biotype and 0.032 mM for the herbicide-resistant biotype
0.028
5-hydroxy-2,6,6-trimethyl-4-[2-[4-(5-trifluoromethyl-pyridin-2-yloxy)-phenoxy]-propionyl]-6H-[1,2]oxazin-3-one
Eleusine indica
-
IC50 is 0.028 mM for the herbicide-sensitive biotype and 0.031 mM for the herbicide-resistant biotype
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000019
5-methoxy-1'-([2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000101
5-methoxy-1'-([2-(pyridazin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000012
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000026
5-methoxy-1'-([2-(pyridin-2-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000019
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000026
5-methoxy-1'-([2-(pyridin-3-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000051
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00006
5-methoxy-1'-([2-(pyridin-4-yl)-1H-benzimidazol-5-yl]carbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000016
5-methoxy-1'-[(2-phenyl-1H-benzimidazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000065
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000104
5-methoxy-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000016
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Rattus norvegicus
-
ACC1
0.000065
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000011
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Rattus norvegicus
-
ACC1
0.000043
5-[(5-methoxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)carbonyl]-N-methyl-1H-indole-2-carboxamide
Homo sapiens
-
ACC2
0.0035
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Setaria viridis
-
IC50 is 0.0035 mM for the herbicide-sensitive biotype and 0.059 mM for the herbicide-resistant biotype
0.0043
5-[2-(5-chloro-pyridin-2-ylsulfanyl)-propyl]-2-[1-[(E)-ethoxyimino]-propyl]-4-fluoro-3-hydroxy-cyclohex-2-enone
Eleusine indica
-
IC50 is 0.0043 mM for the herbicide-sensitive biotype and 0.029 mM for the herbicide-resistant biotype
0.000022
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.000048
6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.0000064
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000013
6-(3,5-dimethyl-1,2-oxazol-4-yl)-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00139
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Rattus norvegicus
-
ACC1
0.00213
6-chloro-1'-(1H-indazol-7-ylcarbonyl)spiro[chromene-2,4'-piperidin]-4(3H)-one
Homo sapiens
-
ACC2
0.000001
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Escherichia coli
-
IC50 for the purified recombinant subunits AccA and AccD is 1 nM
0.000008
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Escherichia coli
-
IC 50 for the wild-type enzyme in crude extract 8 nM
0.00005
6-fluoro-pyridine-2-carboxylic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide
Staphylococcus aureus
-
IC50 for the purified recombinant subunits AccA and AccD is 50 nM
0.000013
andrimid
Escherichia coli
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 13 nM
0.000305
andrimid
Staphylococcus aureus
-
i.e. (2E,4E,6E)-octa-2,4,6-trienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 305 nM
0.00007
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00028
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00059
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00091
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000066
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
Homo sapiens
-
ACC1/2
0.002112
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone
Homo sapiens
-
ACC1/2
0.008
CP-640186
Saccharomyces cerevisiae
-
herbicide, IC50 is 0.008 mM, noncompetititve to malonyl-CoA, molecular inhibitory mechanism, binding structure involving Leu1705 and Val1967, binds to the biotin binding site
0.0014
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.008
ethyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]-amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00025
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0039
methyl [4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000006
moiramide B
Escherichia coli
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, competitive with respect to malonyl-CoA, noncompetitive to biocytin, IC50 for the purified recombinant su
0.000096
moiramide B
Staphylococcus aureus
-
i.e. (2E,4E)-hexa-2,4-dienoic acid [(S)-2-[(S)-2-methyl-1-((3R,4S)-4-methyl-2,5-dioxo-pyrrolidine-3-carbonyl)-propylcarbamoyl]-1-phenyl-ethyl]-amide, IC50 for the purified recombinant subunits AccA and AccD is 96 nM
0.000089
N-(1-(4'-[4-(2-methoxyethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000035
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000113
N-(1-(4'-[4-(phenoxymethyl)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.000017
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC1
0.000033
N-(1-(4'-[4-(propan-2-yloxy)phenoxy]biphenyl-4-yl)ethyl)acetamide
Homo sapiens
-
ACC2
0.0000044
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00019
N-(1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00035
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.01948
N-(1-methyl-3-[2-[4-([[(1-methylethyl)amino]oxy]methyl)phenoxy]-1,3-thiazol-5-yl]prop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000054
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000193
N-(1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]cyclobutyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000036
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
Homo sapiens
-
ACC1
0.000609
N-(1-[4'-(3-propoxyphenoxy)biphenyl-4-yl]ethyl)-1H-pyrazole-4-carboxamide
Homo sapiens
-
ACC2
0.000296
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
Homo sapiens
-
ACC1
0.00055
N-(1-[4'-(4-propoxyphenoxy)biphenyl-4-yl]ethyl)cyclopropanecarboxamide
Homo sapiens
-
ACC2
0.000348
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000811
N-(2-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]propan-2-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000005
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.000027
N-(3-[2-[4-(cyclopentylmethoxy)phenoxy]-1,3-thiazol-5-yl]-1-methylprop-2-yn-1-yl)acetamide
Homo sapiens
-
isozyme ACC2
0.00027
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0027
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.017
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.025
N-(3-[5-[3-(2-cyclopentylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00265
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-cyclopropylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0021
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(2-phenylethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[3-(cyclobutylmethoxy)phenyl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00063
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[5-[6-(cyclopentyloxy)naphthalen-1-yl]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-(3-[trans-5-[4-(benzyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.012
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.012
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.013
N-(3-[trans-5-[4-(cyclopentyloxy)phenoxy]-1,3-dioxan-2-yl]propyl)acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000259
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.01
N-([3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]methyl)acetamide
Homo sapiens
value above, pH and temperature not specified in the publication
0.00004
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000724
N-[(1R)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000024
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000386
N-[(1S)-1-[3-[(2S)-4-(4-ethoxy-2-methylphenyl)-2-methylpiperazin-1-yl]-1,2,4-oxadiazol-5-yl]ethyl]acetamide
Homo sapiens
pH and temperature not specified in the publication
0.0078
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0099
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2R)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00006
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0006
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0023
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0105
N-[(2S)-1-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenoxy)propan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0001
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00092
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[(2S)-4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0018
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0026
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00675
N-[(2S)-4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000015
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00003
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00017
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0004
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00114
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00036
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0008
N-[(2S)-4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00006
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00038
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.01
N-[(2S)-4-[2-[4-(propan-2-yloxy)phenoxy]-1,3-thiazol-5-yl]but-3-yn-2-yl]acetamide
Homo sapiens
-
IC50 above 0.01 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
Homo sapiens
-
ACC1
0.000268
N-[1-(4'-(4-[(5,6,7,8-tetrahydroxynaphthalen-2-yl)oxy]phenoxy)biphenyl-4-yl)ethyl]acetamide
Homo sapiens
-
ACC2
0.00128
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00007
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.014
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[3-(trans-5-[[5-(benzyloxy)pyridin-2-yl]oxy]-1,3-dioxan-2-yl)propyl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.003
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0074
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.02
N-[4-(4-[[2-(propan-2-yloxy)pyrimidin-5-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00021
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00075
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0021
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(benzyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00014
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0011
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0029
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0079
N-[4-(4-[[5-(cyclopentyloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0012
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[5-(propan-2-yloxy)pyrazin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0002
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00178
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0026
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00452
N-[4-(4-[[5-(propan-2-yloxy)pyridin-2-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00008
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0007
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0011
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0079
N-[4-(4-[[6-(benzyloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0067
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0127
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.03
N-[4-(4-[[6-(propan-2-yloxy)pyridazin-3-yl]oxy]phenyl)butan-2-yl]acetamide
Homo sapiens
-
IC50 above 0.03 mM, isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00019
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00062
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0019
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0032
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]cyclopropanecarboxamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.00067
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.0057
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.011
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC1, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.017
N-[4-(4-[[6-(propan-2-yloxy)pyridin-3-yl]oxy]phenyl)butan-2-yl]formamide
Homo sapiens
-
isoform ACC2, in 50 mM Tris-acetate, at 37°C, pH not specified in the publication
0.000099
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.001
tert-butyl ([trans-4-[([[2-(4-[2-[(2-methoxyethyl)-amino]ethyl]piperidin-1-yl)quinolin-4-yl]carbonyl]amino)methyl]cyclohexyl]methyl)carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00057
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0023
tert-butyl [(trans-4-[([[2-(1H-pyrazol-4-yl)quinolin-4-yl]-carbonyl]amino)methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0058
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0083
tert-butyl [(trans-4-[[(2-methyl-6-phenylisonicotinoyl)-amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0045
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0066
tert-butyl [(trans-4-[[(2-phenylisonicotinoyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.000089
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.00078
tert-butyl [(trans-4-[[([2-[4-(2-aminoethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00073
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0053
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperazin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0023
tert-butyl [(trans-4-[[([2-[4-(2-hydroxyethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00069
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0043
tert-butyl [(trans-4-[[([2-[4-(aminomethyl)piperidin-1-yl]quinolin-4-yl]carbonyl)amino]methyl]cyclohexyl)methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.0013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.013
tert-butyl [[trans-4-([[(2-piperazin-1-ylquinolin-4-yl)-carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00024
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0013
tert-butyl [[trans-4-([[(2-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00063
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0045
tert-butyl [[trans-4-([[(2-[3-[2-(dimethylamino)ethoxy]-azetidin-1-yl]-quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
0.00011
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC2, in 50 mM HEPES (pH 7.5), at 37°C
0.0012
tert-butyl [[trans-4-([[(2-[4-[2-(dimethylamino)ethyl]-piperidin-1-yl]quinolin-4-yl)carbonyl]amino]methyl)cyclohexyl]methyl]carbamate
Homo sapiens
-
isoform ACC1, in 50 mM HEPES (pH 7.5), at 37°C
