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6.4.1.2: acetyl-CoA carboxylase

This is an abbreviated version!
For detailed information about acetyl-CoA carboxylase, go to the full flat file.

Word Map on EC 6.4.1.2

Reaction

ATP
+
acetyl-CoA
 +
hydrogencarbonate
=
ADP
 +
phosphate
 +
malonyl-CoA

Synonyms

ACACA, ACACB, ACC, ACC-1, ACC-2, ACC1, Acc1a, Acc1b, Acc1p, ACC2, AccA, ACCalpha, ACCase, ACCase 1, ACCB, AccC, Acetyl CoA carboxylase, Acetyl coenzyme A carboxylase, acetyl coenzyme A carboxylase alpha, acetyl-CoA carboxylase, acetyl-CoA carboxylase 1, acetyl-CoA carboxylase 2, acetyl-CoA carboxylase A, acetyl-CoA carboxylase alpha, acetyl-CoA carboxylase B, acetyl-CoA carboxylase-2, acetyl-CoA carboxylase-alpha, acetyl-CoA-carboxylase, acetyl-CoA/propionyl-CoA carboxylase, Acetyl-coenzyme A carboxylase, acetyl-coenzyme-A carboxylase, acetylCoA carboxylase, acyl coenzyme A carboxylase, acyl-CoA carboxylase, BCCP1, BCCP2, CAC1A, CAC1B, Carboxylase, acetyl coenzyme A, Hfa1p, More, PccB

ECTree

     6 Ligases
         6.4 Forming carbon-carbon bonds
             6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
                6.4.1.2 acetyl-CoA carboxylase

Specific Activity

Specific Activity on EC 6.4.1.2 - acetyl-CoA carboxylase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000132
pH 8, 20°C
0.000009
-
wild-type tuber
0.000086 - 0.000096
-
transgenic tubers highly overexpressing the Arabidopsis thaliana enzyme
0.0002
-
crude extract, pH 7.8, 60°C
0.00033
-
wild type rat liver, 37°C
0.00038
-
ACC activity in hypothalamus
0.0004
-
acetyl-CoA carboxylase activity, strain CE3
0.0005
-
acetyl-CoA carboxylase activity, strain 12-53
0.0007
-
ACC activity in liver
0.00096
cell lysate
0.001
-
acetyl-CoA carboxylase activity, strain CFNX218
0.0015
-
control rats, pH 7.5, 37°C
0.0025
0.006
-
propionyl-CoA carboxylase activity, strain CE3
0.0064
-
propionyl-CoA carboxylase activity, strain 12-53
0.0078
-
propionyl-CoA carboxylase activity, strain CFNX218
0.00875
-
JCR:LA-cp rat liver, 37°C
0.00921
after purification
0.013
-
crude extract, pH 7.8, 55°C
0.015
-
crude extract, pH 7.8, 55°C
0.065
-
-
0.092
-
seed
0.121
-
leaf
0.244
-
-
0.3
purified recombinant enzyme
0.4
-
purified recombinant enzyme
0.786
recombinant N-terminal deletion mutant, pH 7.4, 37°C
0.844
-
-
1.336
recombinant N-terminal deletion mutant treated with Lambda protein phosphatase, pH 7.4, 37°C
1.363
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 5 mM citrate
14.5
Q877I4; Q877I3; Q877I5
pH 7.5, 70°C, acetyl-CoA carboxylase activity
154.9
-
purified plastidic enzyme from strain Rothamsted, pH 8.0, 30°C
184.2
-
purified plastidic enzyme, pH 8.0, 30°C
2.246
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 10 mM citrate
2.6
-
hindlimb muscle
217
-
purified plastidic enzyme, pH 8.0, 30°C
24.9
-
purified cytosolic enzyme, pH 8.0, 30°C
26.93
-
purified native enzyme
3.2
purified enzyme, pH 7.5, 65°C
34.9
-
purified cytosolic enzyme, pH 8.0, 30°C
4.186
recombinant N-terminal deletion mutant, pH 7.4, 37°C, presence of 20 mM citrate
41.3
-
purified cytosolic enzyme from strain Rothamsted, pH 8.0, 30°C
5.54
-
-
52.4
-
purified plastidic enzyme from strain Notts A1, pH 8.0, 30°C
7.27
-
purified enzyme, substrate propionyl-CoA
additional information