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Disease on EC 6.4.1.2 - acetyl-CoA carboxylase

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DISEASE
TITLE OF PUBLICATION
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acetyl-coa carboxylase deficiency
Acetyl-CoA carboxylase deficiency: an inborn error of de novo fatty acid synthesis.
Acne Vulgaris
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Adenocarcinoma
Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK.
Overexpressing TNF-Alpha in Pancreatic Ductal Adenocarcinoma Cells and Fibroblasts Modifies Cell Survival and Reduces Fatty Acid Synthesis via Downregulation of Sterol Regulatory Element Binding Protein-1 and Activation of Acetyl CoA Carboxylase.
Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours.
Tissue specificity for the effect of estrogen on lipogenic activity in male and female rats.
Alzheimer Disease
AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on ?-amyloid clearance.
Asthma
Different effects of acetyl-CoA carboxylase inhibitor TOFA on airway inflammation and airway resistance in a mice model of asthma.
Ataxia Telangiectasia
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Azotemia
High-calorie diet partially ameliorates dysregulation of intrarenal lipid metabolism in remnant kidney.
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Bacterial Infections
Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs.
Breast Neoplasms
3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.
Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.
Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility.
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival.
Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells.
BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.
Breast cancer 1 (BrCa1) may be behind decreased lipogenesis in adipose tissue from obese subjects.
Effect of branched-chain fatty acids on fatty acid biosynthesis of human breast cancer cells.
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.
Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.
Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition.
Identification of human acetyl-CoA carboxylase isozymes in tissue and in breast cancer cells.
MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1.
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.
carboxylesterase deficiency
Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation.
Carcinogenesis
AMPK ?1 reduces tumor progression and improves survival in p53 null mice.
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.
Long Noncoding RNA CTD-2245E15.3 Promotes Anabolic Enzymes ACC1 and PC to Support Non-Small Cell Lung Cancer Growth.
Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model.
Carcinoma
Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck.
Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver.
Effect of exogenous bFGF on the proliferation of human adenoid cystic carcinoma ACC-2 cells.
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.
FZD2 inhibits the cell growth and migration of salivary adenoid cystic carcinomas.
Identification of genes with consistent expression alteration pattern in ACC-2 and ACC-M cells by cDNA array.
Influence of Ginkgo biloba extract on the proliferation, apoptosis of ACC-2 cell and Survivin gene expression in adenoid cystic carcinoma of lacrimal gland.
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase.
Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.
The endocytic pathways of carbon dots in human adenoid cystic carcinoma cells.
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma.
[Analysis of differential expression genes related to different metastasis potential of adenoid cystic carcinoma using restriction fragments differential display PCR]
[Construction of recombinant plasmid vector pIRES-CD and its expression in ACC-2 cells]
[Effect of mechanical stimulation on the invasion in salivary adenoid cystic carcinoma]
[Effects of basic fibroblast growth factor on the proliferation of human salivary adenoid cystic carcinoma cell line ACC-2 and extracellular signal-regulated kinase, Cyclin D1, p2waf/cip1 signaling pathway]
[Evaluation of TGF-beta1 expressed by oral and maxillofacial malignant neoplasm]
[Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma]
[Influence of Ginkgo biloba extract on proliferation of ACC-2 cell, Survivin and TIP30 gene expression in adenoid cystic carcinoma of lacrimal gland].
[RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M].
[Verapamil enhancement of antitumor activity of mitoxantrone on ACC-22 cells in citro]
Carcinoma, Adenoid Cystic
Effect of exogenous bFGF on the proliferation of human adenoid cystic carcinoma ACC-2 cells.
FZD2 inhibits the cell growth and migration of salivary adenoid cystic carcinomas.
Identification of genes with consistent expression alteration pattern in ACC-2 and ACC-M cells by cDNA array.
Influence of Ginkgo biloba extract on the proliferation, apoptosis of ACC-2 cell and Survivin gene expression in adenoid cystic carcinoma of lacrimal gland.
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
The endocytic pathways of carbon dots in human adenoid cystic carcinoma cells.
[Analysis of differential expression genes related to different metastasis potential of adenoid cystic carcinoma using restriction fragments differential display PCR]
[Construction of recombinant plasmid vector pIRES-CD and its expression in ACC-2 cells]
[Effect of mechanical stimulation on the invasion in salivary adenoid cystic carcinoma]
[Effects of basic fibroblast growth factor on the proliferation of human salivary adenoid cystic carcinoma cell line ACC-2 and extracellular signal-regulated kinase, Cyclin D1, p2waf/cip1 signaling pathway]
[Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma]
[Influence of Ginkgo biloba extract on proliferation of ACC-2 cell, Survivin and TIP30 gene expression in adenoid cystic carcinoma of lacrimal gland].
[RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M].
[Verapamil enhancement of antitumor activity of mitoxantrone on ACC-22 cells in citro]
Carcinoma, Hepatocellular
Acetyl-CoA carboxylase in Reuber hepatoma cells: variation in enzyme activity, insulin regulation, and cellular lipid content.
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
Activities of enzymes of lipid metabolism in Morris hepatoma 7800 C1 cells.
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.
An autocrine factor from Reuber hepatoma cells that stimulates DNA synthesis and acetyl-CoA carboxylase. Characterization of biologic activity and evidence for a glycan structure.
Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells.
Coordinate regulation of lipogenesis, the assembly and secretion of apolipoprotein B-containing lipoproteins by sterol response element binding protein 1.
Functional Single-Nucleotide Polymorphism in Acetyl-CoA Carboxylase ACACB Gene Promoter.
Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells.
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
Insulin stimulates the dephosphorylation and activation of acetyl-CoA carboxylase.
Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice.
POSSIBLE REGULATION OF LDL-RECEPTOR BY NARINGENIN IN HEPG2 HEPATOMA CELL LINE.
Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
The ménage à trois of autophagy, lipid droplets and liver disease.
Unmetabolized fenofibrate, but not fenofibric acid, activates AMPK and inhibits the expression of phosphoenolpyruvate carboxykinase in hepatocytes.
Carcinoma, Lobular
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.
Immunocytochemical demonstration of calmodulin and its activated forms in normal and carcinomatous human mammary tissue.
Carcinoma, Mucoepidermoid
[Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma]
Carcinoma, Non-Small-Cell Lung
Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer.
Carcinoma, Renal Cell
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Carcinoma, Squamous Cell
Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck.
The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma.
[Evaluation of TGF-beta1 expressed by oral and maxillofacial malignant neoplasm]
Cardiomegaly
Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.
Cardiomyopathies
Increasing Fatty Acid Oxidation Prevents High-Fat Diet-Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy.
Cholera
Regulation of acetyl-CoA carboxylase by ADP-ribosylation.
Colitis
Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection.
Colonic Neoplasms
Dual role of insulin-like growth factor-1 in acetyl-CoA carboxylase-alpha activity in human colon cancer cells HCT-8: downregulating its expression and phosphorylation.
Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells.
Label-free quantitative proteomic profiling of colon cancer cells identifies acetyl-CoA carboxylase alpha as antitumor target of Citrus limon-derived nanovesicles.
Colorectal Neoplasms
Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer.
Coronary Artery Disease
Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.
Cystic Fibrosis
Acetyl-CoA carboxylase inhibition regulates microtubule dynamics and intracellular transport in cystic fibrosis epithelial cells.
Dengue
Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models.
Diabetes Mellitus
A Gene Polymorphism in Acetyl-Coenzyme A Carboxylase Beta may be Associated with the C-Reactive Protein Level in a Prediabetic and Diabetic Population.
Association of ACACB polymorphisms with obesity and diabetes.
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs.
Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008.
The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes.
Diabetes Mellitus, Experimental
Acute alloxan diabetes alters the activity but not the total quantity of acetyl CoA carboxylase in rat liver.
Diabetes Mellitus, Type 2
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.
A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes.
Acetyl-CoA carboxylase 2 inhibition reduces skeletal muscle bioactive lipid content and attenuates progression of type 2 diabetes in Zucker diabetic fatty rats.
An ACACB Variant Implicated in Diabetic Nephropathy Associates with Body Mass Index and Gene Expression in Obese Subjects.
Aqueous-Methanol Extracts of Orange-Fleshed Sweet Potato (Ipomoeabatatas) Ameliorate Oxidative Stress and Modulate Type 2 Diabetes Associated Genes in Insulin Resistant C2C12 Cells.
Association of ACACB polymorphisms with obesity and diabetes.
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.
Identification of dual Acetyl-CoA carboxylases 1 and 2 inhibitors by pharmacophore based virtual screening and molecular docking approach.
Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity.
Overexpression of acetyl CoA carboxylase ? exacerbates podocyte injury in the kidney of streptozotocin-induced diabetic mice.
Overexpression of acetyl-coenzyme A carboxylase beta increases proinflammatory cytokines in cultured human renal proximal tubular epithelial cells.
Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008.
Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.
The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes.
The association between lipid metabolism gene polymorphisms and nephropathy in type 2 diabetes: a meta-analysis.
The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
Diabetic Nephropathies
A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes.
An ACACB Variant Implicated in Diabetic Nephropathy Associates with Body Mass Index and Gene Expression in Obese Subjects.
Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy(&)
Overexpression of acetyl CoA carboxylase ? exacerbates podocyte injury in the kidney of streptozotocin-induced diabetic mice.
Overexpression of acetyl-coenzyme A carboxylase beta increases proinflammatory cytokines in cultured human renal proximal tubular epithelial cells.
The ACACB gene rs2268388 polymorphism is associated with nephropathy in Caucasian patients with diabetes: a meta-analysis.
The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes.
The association between lipid metabolism gene polymorphisms and nephropathy in type 2 diabetes: a meta-analysis.
Dyslipidemias
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.
Decrease in FASN Expression in Adipose Tissue of Hypertensive Individuals.
[Effect of quercetin on the expression of the carbohydrate and lipid metabolism genes in the liver of rats with genetic].
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Endophthalmitis
5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis.
Fatty Liver
Acetyl-CoA carboxylase 2 -/- mutant mice are protected against fatty liver under High-fat, high-carbohydrate dietary and de novo lipogenic conditions.
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.
Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver.
Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKK?/AMPK/ACC Pathway.
Differential gene expression in dairy cows under negative energy balance and ketosis: A systematic review and meta-analysis.
ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development.
Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken.
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model.
Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.
GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH).
Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice.
Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity.
Involvement of adenosine monophosphate-activated protein kinase in the influence of timed high-fat evening diet on the hepatic clock and lipogenic gene expression in mice.
Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism.
Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly.
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Selective acetyl-CoA carboxylase 1 inhibitor improves hepatic steatosis and hepatic fibrosis in a pre-clinical NASH model.
Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause.
Supplementation of Inulin with Various Degree of Polymerization Ameliorates Liver Injury and Gut Microbiota Dysbiosis in High Fat-Fed Obese Mice.
The ménage à trois of autophagy, lipid droplets and liver disease.
The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis.
[6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis.
Fetal Alcohol Spectrum Disorders
Bioactivity-Guided Isolation and Identification of Anti-adipogenic Constituents from the n-Butanol Fraction of Cissus quadrangularis.
Flavivirus Infections
Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models.
Glioblastoma
Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.
Phosphorylated Acetyl-CoA Carboxylase Is Associated with Clinical Benefit with Regorafenib in Relapsed Glioblastoma: REGOMA Trial Biomarker Analysis.
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.
Glioma
Genomic changes in progression of low-grade gliomas.
Graft vs Host Disease
Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease.
Minor histocompatibility antigens as determinants for graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.
Healthcare-Associated Pneumonia
A novel type of AmpC beta-lactamase, ACC-1, produced by a Klebsiella pneumoniae strain causing nosocomial pneumonia.
Heart Failure
Puerarin inhibits apoptosis and inflammation in myocardial cells via PPAR? expression in rats with chronic heart failure.
Hepatomegaly
Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation.
Huntington Disease
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Hypercholesterolemia
Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.
[Formation of mevalonic acid, sterols and bile acids from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in the liver of rabbits with experimental hypercholesterolemia]
Hyperglycemia
A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways.
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.
Intermittent food restriction in female rats induces SREBP high expression in hypothalamus and immediately postfasting hyperphagia.
Hyperinsulinism
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.
Modulation of the activity of insulin-dependent enzymes of lipogenesis by glucocorticoids.
Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats.
Hyperlipidemias
Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition.
Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKK?/AMPK/ACC Pathway.
Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease.
Interaction of renin-angiotensin system and adenosine monophosphate-activated protein kinase signaling pathway in renal carcinogenesis of uninephrectomized rats.
Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia.
Hyperlipoproteinemias
Hyperlipoproteinemia of aminonucleoside-induced nephrotic syndrome--modulation by glucocorticoids and triiodothyronine.
Hypersensitivity
Efficient Plastid Transformation in Arabidopsis.
Hypertension
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
Hyperthyroidism
Effect of hyperthyroidism on lipogenesis in brown adipose tissue of young rats.
Effect of thyroid hormones on microsomal fatty acid chain elongation synthesis in rat liver.
Expression and activity of lipid and oxidative metabolism enzymes following elevated temperature exposure and thyroid hormone manipulation in juvenile lake whitefish (Coregonus clupeaformis).
Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle.
Hypertriglyceridemia
Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.
Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.
Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats.
Hypotension
Effect of maternal nutrient restriction from early to midgestation on cardiac function and metabolism after adolescent-onset obesity.
Infections
AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis.
Distinct Roles for Intracellular and Extracellular Lipids in Hepatitis C Virus Infection.
Fatty Acids Regulate Porcine Reproductive and Respiratory Syndrome Virus Infection via the AMPK-ACC1 Signaling Pathway.
Insulin-like effects of fatty acid synthesis in liver of hamsters infected with plerocercoids of the tapeworm, Spirometra mansonoides.
Metabolic profiles of fish nodavirus infection in vitro: RGNNV induced and exploited cellular fatty acid synthesis for virus infection.
Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models.
The octadecanoid pathway is required for pathogen-induced multi-functional acetyl-CoA carboxylase accumulation in common bean (Phaseolus vulgaris L.).
Insulin Resistance
A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways.
Acetyl-CoA carboxylase 2 -/- mutant mice are protected against fatty liver under High-fat, high-carbohydrate dietary and de novo lipogenic conditions.
Acetyl-CoA carboxylase 2 inhibition reduces skeletal muscle bioactive lipid content and attenuates progression of type 2 diabetes in Zucker diabetic fatty rats.
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.
AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.
An increase in peroxisomal fatty acid oxidation is not sufficient to prevent tissue lipid accumulation in hHTg rats.
Changes in lipid synthesis in rat adipose tissue during development.
Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.
CIDEC/FSP27 and PLIN1 gene expression run in parallel to mitochondrial genes in human adipose tissue, both increasing after weight loss.
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.
Decrease in FASN Expression in Adipose Tissue of Hypertensive Individuals.
Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects.
Development of insulin sensitivity in white adipose tissue during the suckling-weaning transition in the rat. Involvement of glucose transport and lipogenesis.
Diminished activities of fatty acid synthesis enzymes in insulin-resistant adipocytes from spontaneously obese rats.
Effects of dietary fatty acids on insulin sensitivity and secretion.
Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.
Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity.
Faster lipid ?-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1? in human podocytes.
Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits.
Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats.
Identification of Adipocyte Genes Regulated by Caloric Intake.
Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.
Kochujang, a Korean fermented red pepper plus soybean paste, improves glucose homeostasis in 90% pancreatectomized diabetic rats.
Liraglutide improves insulin sensitivity in high fat diet induced diabetic mice through multiple pathways.
Overexpression of PGC-1? improves insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes.
Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase.
Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice.
Rosiglitazone reduces fatty acid translocase and increases AMPK in skeletal muscle in aged rats: a possible mechanism to prevent high-fat-induced insulin resistance.
Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats.
Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet.
The effect of ACACB cis-variants on gene expression and metabolic traits.
The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices.
The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity.
Ketosis
High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis.
Kidney Failure, Chronic
Adiponectin receptor and adiponectin signaling in human tissue among patients with end-stage renal disease.
Kidney Neoplasms
Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer.
Leiomyomatosis
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Leukemia
Decreased activity of acetyl-CoA carboxylase during chemically induced neutrophilic differentiation of human promyelocytic leukemia cells.
Leukemia, Myeloid
Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.
Leukemia, Myeloid, Acute
Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.
Lipid Metabolism Disorders
Effects of Portulaca Oleracea Extract on Acute Alcoholic Liver Injury of Rats.
Nano-selenium alleviating the lipid metabolism disorder of LMH cells induced by potassium dichromate via down-regulating ACACA and FASN.
The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet.
Liver Diseases
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.
Differential gene expression in dairy cows under negative energy balance and ketosis: A systematic review and meta-analysis.
Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Novel Thienopyrimidines as Acetyl-CoA Carboxylase Inhibitors for Treating Liver Diseases.
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs.
Selective acetyl-CoA carboxylase 1 inhibitor improves hepatic steatosis and hepatic fibrosis in a pre-clinical NASH model.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
The ménage à trois of autophagy, lipid droplets and liver disease.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Neoplasms
Aberrant lipid metabolism as a therapeutic target in liver cancer.
Liver-specific expression of an exogenous gene controlled by human apolipoprotein A-I promoter.
Lung Neoplasms
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.
Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer.
Lymphoma, B-Cell
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBP?/SREBP-1 pathway.
Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer.
Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure.
Malnutrition
Soybean diet modulates acetyl-coenzyme A carboxylase expression in livers of rats recovering from early-life malnutrition.
Mammary Neoplasms, Animal
Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours.
Melanoma
Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: application for allogeneic transplantation.
Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell.
Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi.
Metabolic Diseases
Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity.
Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease.
Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.
Metabolic Syndrome
A herbal extract with acetyl-coenzyme A carboxylase inhibitory activity and its potential for treating metabolic syndrome.
Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors.
Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome.
BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.
Inhibitors of mammalian acetyl-CoA carboxylase.
Intestinal Population in Host with Metabolic Syndrome during Administration of Chitosan and Its Derivatives.
Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals.
Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.
Stimulation of Fat Oxidation, but no Sustained Reduction of Hepatic Lipids by Prolonged Pharmacological Inhibition of Acetyl CoA Carboxylase.
The metabolic benefits of Polygonum hypoleucum Ohwi in HepG2 cells and Wistar rats under lipogenic stress.
Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition.
Multiple Carboxylase Deficiency
Acetyl CoA carboxylase in cultured fibroblasts: differential biotin dependence in the two types of biotin-responsive multiple carboxylase deficiency.
Deficient acetyl CoA carboxylase activity in multiple carboxylase deficiency.
Fatty acid transport in multiple carboxylase deficiency fibroblasts.
Neoplasm Metastasis
Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.
MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1.
Promoting effects on the proliferation and metastasis of ACC tumor cell with XAGE-1b overexpression.
Proteomics analysis of differentially expressed metastasis-associated proteins in adenoid cystic carcinoma cell lines of human salivary gland.
Study of the difference of high and low metastasis cell line's gene expression map and metastasis-related genes of adenoid cystic carcinoma.
[Analysis of differential expression genes related to different metastasis potential of adenoid cystic carcinoma using restriction fragments differential display PCR]
[Effect of mechanical stimulation on the expression of E-cadherin/cateninin complex in salivary adenoid cystic carcinoma]
[Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma]
[Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma]
[The effect of FN(fibronectin) on invasion and metastasis of human acinic cell carcinoma cell strain of the salivary gland]
Neoplasms
1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer.
Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility.
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival.
Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth.
Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.
Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis.
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via ?-ketoglutarate.
Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death.
Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells.
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Antitumor effects of curcumin: A lipid perspective.
Autophagy in the physiological endometrium and cancer.
Bifidobacteria and its rice fermented products on diet induced obese mice: analysis of physical status, serum profile and gene expressions.
Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model.
BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.
Breast Cancer Subtypes Underlying EMT-Mediated Catabolic Metabolism.
Cardiac metabolism, inflammation, and peroxisome proliferator-activated receptors modulated by 1,25-dihydroxyvitamin D3 in diabetic rats.
Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study.
Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells.
Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells.
Comprehensive molecular characterization of clear cell renal cell carcinoma.
Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells.
Dietary Supplementation with ?-Ketoglutarate Activates mTOR Signaling and Enhances Energy Status in Skeletal Muscle of Lipopolysaccharide-Challenged Piglets.
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Down-regulation of ACACA suppresses the malignant progression of Prostate Cancer through inhibiting mitochondrial potential.
Doxorubicin-loaded environmentally friendly carbon dots as a novel drug delivery system for nucleus targeted cancer therapy.
Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.
Effect of tumor necrosis factor on acetyl-coenzyme A carboxylase gene expression and preadipocyte differentiation.
Effects of intravenous infusion of trans-10, cis-12 18:2 on mammary lipid metabolism in lactating dairy cows.
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells.
Exome sequencing in 51 early onset non-familial CRC cases.
Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.
Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPAR? Regulation in Hyperlipidemic and Hypertensive Conditions.
Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression.
Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells.
Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis.
Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells.
Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition.
HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy.
Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice.
Immunocytochemical demonstration of calmodulin and its activated forms in normal and carcinomatous human mammary tissue.
Immunohistochemical study of the distribution of endogenous biotin and biotin-binding enzymes in ductal structures of salivary gland tumours.
Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).
Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis.
Increased lipogenesis in cancer cells: new players, novel targets.
Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.
Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4.
Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK.
Label-free quantitative proteomic profiling of colon cancer cells identifies acetyl-CoA carboxylase alpha as antitumor target of Citrus limon-derived nanovesicles.
Lipid accumulation and dendritic cell dysfunction in cancer.
Lipid metabolism and enzyme activities in hormone-dependent and hormone-independent mammary adenocarcinoma in GR mice.
Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer.
Lipogenesis in cancer progression (review).
Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
MicroRNA155 in the growth and invasion of salivary adenoid cystic carcinoma.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Oral formulation of angiotensin-(1-7) improves lipid metabolism and prevents high-fat diet-induced hepatic steatosis and inflammation in mice.
Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer.
Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth.
Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation.
Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells.
Promoting effects on the proliferation and metastasis of ACC tumor cell with XAGE-1b overexpression.
Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat.
Proteomics analysis of differentially expressed metastasis-associated proteins in adenoid cystic carcinoma cell lines of human salivary gland.
Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs.
Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.
Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action.
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer.
Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1.
Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.
Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours.
Synergistic Effect of Omega-3 Fatty Acids and Oral-Hypoglycemic Drug on Lipid Normalization through Modulation of Hepatic Gene Expression in High Fat Diet with Low Streptozotocin-Induced Diabetic Rats.
Synthesis and biological evaluation of 4-phenoxy-phenyl isoxazoles as novel acetyl-CoA carboxylase inhibitors.
Synthesis and in vitro evaluation of novel spiroketopyrazoles as acetyl-CoA carboxylase inhibitors and potential antitumor agents.
Targeting de novo lipogenesis as a novel approach in anti-cancer therapy.
Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression.
Targeting Mitochondrial Citrate Transport in Breast Cancer Cell Lines.
The acetyl-CoA carboxylase enzyme: a target for cancer therapy?
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
The potential of antioxidant-rich Maoberry (Antidesma bunius) extract on fat metabolism in liver tissues of rats fed a high-fat diet.
The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma.
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Transcriptional regulation of acetyl coenzyme A carboxylase gene expression by tumor necrosis factor in 30A-5 preadipocytes.
Type 2 diabetes is associated with altered NF-?B DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS.
Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity.
Whole transcriptome analysis identifies differentially regulated networks between osteosarcoma and normal bone samples.
Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model.
[Analysis of differentially expressed lung metastasis-associated proteins in adenoid cystic carcinoma cell lines]
[Cancer stem cells: its existence, proliferation and differentiation in an adenoid cystic carcinoma cell line]
[Experimental study of radiosensitization of buthionine sulffoximine (BSO) on Acc-2 transplanted tumor]
[Influence of Ginkgo biloba extract on proliferation of ACC-2 cell, Survivin and TIP30 gene expression in adenoid cystic carcinoma of lacrimal gland].
[The expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in transplanted tumor of salivary adenoid cystic carcinoma cell lines]
Nephrosis
Effect of renal microsomes and renal lysosomes on in vitro hepatic fatty acid synthesis.
Nephrotic Syndrome
Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion.
Neuroblastoma
24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury.
Nevus
Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi.
Non-alcoholic Fatty Liver Disease
A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats.
Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.
Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.
Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.
Acetyl-Coenzyme A carboxylase inhibition Delivers, as Anticipated, for Patients With Nonalcoholic Steatohepatitis.
Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease.
Chokeberry attenuates the expression of genes related to de novo lipogenesis in the hepatocytes of mice with nonalcoholic fatty liver disease.
Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease.
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity.
Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Ppar?).
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding.
Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs.
Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats.
The ménage à trois of autophagy, lipid droplets and liver disease.
Trimming the Fat: Acetyl-CoA Carboxylase Inhibition for the Management of NAFLD.
WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice.
Obesity
Acetyl-CoA carboxylase 2 -/- mutant mice are protected against fatty liver under High-fat, high-carbohydrate dietary and de novo lipogenic conditions.
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death.
Alterations in acetyl coenzyme A carboxylase activities in voles and mice treated with monosodium aspartate.
An ACACB Variant Implicated in Diabetic Nephropathy Associates with Body Mass Index and Gene Expression in Obese Subjects.
Association of ACACB polymorphisms with obesity and diabetes.
Changes in hepatic lipogenic enzyme activities in voles and mice treated with monosodium aspartate.
CIDEC/FSP27 and PLIN1 gene expression run in parallel to mitochondrial genes in human adipose tissue, both increasing after weight loss.
Decrease in FASN Expression in Adipose Tissue of Hypertensive Individuals.
Dietary calcium regulates the risk renal injury in high fat diet induced obese rats by regulating renal lipid metabolism, oxidative stress and inflammation.
Expression of genes regulating Malonyl-CoA in human skeletal muscle.
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
Hypolipidemic Activity of Peony Seed Oil Rich in ?-Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid ?-Oxidation.
Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.
Improving production of malonyl coenzyme A-derived metabolites by abolishing Snf1-dependent regulation of Acc1.
Inhibition of acetyl-CoA carboxylase by cystamine may mediate the hypotriglyceridemic activity of pantethine.
Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity.
Inhibition of acetyl-CoA carboxylase isoforms by pyridoxal phosphate.
Inhibitors of mammalian acetyl-CoA carboxylase.
Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.
Liver acetyl CoA carboxylase and fatty acid synthetase: relative activities in the normal state and in hereditary obesity.
Mitochondrial storage forms of acetyl CoA carboxylase: mobilization/activation accounts for increased activity of the enzyme in liver of genetically obese Zucker rats.
Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity.
Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008.
Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.
Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet.
The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices.
Treatment of Obesity and Related Disorders with Acetyl-CoA Carboxylase Inhibitors.
Ultra-fast simultaneous detection of obesity-related coenzymes in mice using microchip electrophoresis with a LIF detector.
WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPAR? pathway.
[Full transcriptome analysis of gene expression in liver of mice in a comparative study of quercetin efficiency on two obesity models].
Obesity, Abdominal
Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase.
Obesity, Maternal
Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis.
Obesity, Morbid
Association of ACACB polymorphisms with obesity and diabetes.
Ovarian Neoplasms
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival.
Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death.
Overweight
Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study.
Pancreatic Neoplasms
Glutamine Deprivation Enhances Acetyl-CoA Carboxylase Inhibitor-induced Death of Human Pancreatic Cancer Cells.
Paratuberculosis
Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.
Pediatric Obesity
Identification of key genes and pathways associated with obesity in children.
peptidyl-glutamate 4-carboxylase deficiency
Acetyl CoA carboxylase in cultured fibroblasts: differential biotin dependence in the two types of biotin-responsive multiple carboxylase deficiency.
Deficient acetyl CoA carboxylase activity in multiple carboxylase deficiency.
Fatty acid transport in multiple carboxylase deficiency fibroblasts.
[Multiple biotin-dependent carboxylase deficiencies (author's transl)]
proprotein convertase 2 deficiency
Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain.
Prostatic Neoplasms
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.
Chemistry and biology for the small molecules targeting characteristics of cancer cells.
Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study.
Down-regulation of ACACA suppresses the malignant progression of Prostate Cancer through inhibiting mitochondrial potential.
Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation.
Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
Proteinuria
A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes.
High-calorie diet partially ameliorates dysregulation of intrarenal lipid metabolism in remnant kidney.
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
Overexpression of acetyl CoA carboxylase ? exacerbates podocyte injury in the kidney of streptozotocin-induced diabetic mice.
Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion.
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus.
Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.
Pruritus
Farnesoid X nuclear receptor agonists for the treatment of nonalcoholic steatohepatitis.
Sarcoma
Intralipid decreases apolipoprotein M levels and insulin sensitivity in rats.
Squamous Cell Carcinoma of Head and Neck
The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma.
Starvation
Activity of acetyl-CoA carboxylase is not directly linked to accumulation of lipids when Chlorella vulgaris is co-immobilised with Azospirillum brasilense in alginate under autotrophic and heterotrophic conditions
Age-dependent hepatic lipogenic enzyme activities in starved-refed rats.
Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture.
Changes in the proportion of acetyl-CoA carboxylase in the active form in rat liver. Effect of starvation, lactation and weaning.
Effect of starvation on hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats.
Effects of starvation, insulin or prolactin deficiency on the activity of acetyl-CoA carboxylase in mammary gland and liver of lactating rats.
Gene expression in primate liver during viral hemorrhagic fever.
High carbohydrate diet and starvation regulate lipogenic mRNA in rats in a tissue-specific manner.
Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity.
Metabolic Stress-Induced Activation of AMPK and Inhibition of Constitutive Phosphoproteins Controlling Smooth Muscle Contraction: Evidence for Smooth Muscle Fatigue?
Regulation of acetyl-CoA carboxylase in rat mammary gland. Effects of starvation and of insulin and prolactin deficiency on the fraction of the enzyme in the active form in vivo.
Regulation of fatty acid synthesis and malonyl-CoA content in mouse brown adipose tissue in response to cold-exposure, starvation or re-feeding.
Regulation of fatty acid synthesis in lactating rat mammary gland in the fed to starved transition: asynchronous control of pyruvate dehydrogenase, phosphofructokinase and acetyl-CoA carboxylase.
Starvation and feeding a high-carbohydrate, low-fat diet regulate the expression sterol regulatory element-binding protein-1 in chickens.
The effect of nitrogen limitation on acetyl-CoA carboxylase expression and fatty acid content in Chromera velia and Isochrysis aff. galbana (TISO).
The role of acetyl-CoA carboxylase phosphorylation in the control of mammary gland fatty acid synthesis during the starvation and re-feeding of lactating rats.
The short-term regulation of hepatic acetyl-CoA carboxylase during starvation and re-feeding in the rat.
Thyroid hormone, glucagon, and medium-chain fatty acids regulate transcription initiated from promoter 1 and promoter 2 of the acetyl-CoA carboxylase-alpha gene in chick embryo hepatocytes.
[Activities of 3-hydroxyl-3-methylglutaryl-CoA reductase and acetyl-CoA carboxylase and the rate of mevalonic acid, squalene, sterol and fatty acid biosynthesis from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in rat liver: effects of Triton WR 1339, starvation and cholesterol diet]
Stomach Neoplasms
Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis.
Thiamine Deficiency
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Thymoma
A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation.
Expression of cardiac insulin signalling genes and proteins in rats fed a high-sucrose diet: effect of bilberry anthocyanin extract.
Thyroid Cancer, Papillary
Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in BRAFV600E Papillary Thyroid Carcinoma.
Trypanosomiasis, African
Trypanosoma brucei: inhibition of acetyl-CoA carboxylase by haloxyfop.
Tuberculosis
A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility.
Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis.
Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis.
Computational exploration and anti-mycobacterial activity of potential inhibitors of Mycobacterium tuberculosis acetyl coenzyme A carboxylase as anti-tubercular agents.
Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis.
Expression, purification and preliminary crystallographic analysis of Rv2247, the ? subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis.
Functional reconstitution of the Mycobacterium tuberculosis long-chain acyl-CoA carboxylase from multiple acyl-CoA subunits.
Identification and Characterization of Rv3281 as a Novel Subunit of a Biotin-dependent Acyl-CoA Carboxylase in Mycobacterium tuberculosis H37Rv.
Pleiotropic effect of AccD5 and AccE5 depletion in acyl-coenzyme A carboxylase activity and in lipid biosynthesis in mycobacteria.
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis.
Structure, activity, and inhibition of the Carboxyltransferase ?-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis.
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis.
The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium.
Tuberous Sclerosis
AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep.
Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion.
Vascular System Injuries
Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.
Virus Diseases
A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients.
Vitamin B 6 Deficiency
Effect of vitamin B6 deficiency on the levels of several water-soluble vitamins in tissues of germ-free and conventional rats.
Zika Virus Infection
AMP-Activated Protein Kinase Restricts Zika Virus Replication in Endothelial Cells by Potentiating Innate Antiviral Responses and Inhibiting Glycolysis.