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6.4.1.2: acetyl-CoA carboxylase

This is an abbreviated version!
For detailed information about acetyl-CoA carboxylase, go to the full flat file.

Word Map on EC 6.4.1.2

Reaction

ATP
+
acetyl-CoA
 +
hydrogencarbonate
=
ADP
 +
phosphate
 +
malonyl-CoA

Synonyms

ACACA, ACACB, ACC, ACC-1, ACC-2, ACC1, Acc1a, Acc1b, Acc1p, ACC2, AccA, ACCalpha, ACCase, ACCase 1, ACCB, AccC, Acetyl CoA carboxylase, Acetyl coenzyme A carboxylase, acetyl coenzyme A carboxylase alpha, acetyl-CoA carboxylase, acetyl-CoA carboxylase 1, acetyl-CoA carboxylase 2, acetyl-CoA carboxylase A, acetyl-CoA carboxylase alpha, acetyl-CoA carboxylase B, acetyl-CoA carboxylase-2, acetyl-CoA carboxylase-alpha, acetyl-CoA-carboxylase, acetyl-CoA/propionyl-CoA carboxylase, Acetyl-coenzyme A carboxylase, acetyl-coenzyme-A carboxylase, acetylCoA carboxylase, acyl coenzyme A carboxylase, acyl-CoA carboxylase, BCCP1, BCCP2, CAC1A, CAC1B, Carboxylase, acetyl coenzyme A, Hfa1p, More, PccB

ECTree

     6 Ligases
         6.4 Forming carbon-carbon bonds
             6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
                6.4.1.2 acetyl-CoA carboxylase

Molecular Weight

Molecular Weight on EC 6.4.1.2 - acetyl-CoA carboxylase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10000000
-
gel filtration enzyme exists in two polymeric forms of MW 2000000 and 10000000, interconvertible by phosphorylation and dephosphorylation. The 10000000 MW form predomionantly exists in preparations of freeze-clamped liver
105000
-
x * 105000 + x * 210000, SDS-PAGE
110000
-
x * 110000, ultracentrifugation in presence of 6 M guanidine hydrochloride and 0.1 M 2-mercaptoethanol
12000
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
180000
-
gel filtration
185000
-
4 * 185000, SDS-PAGE
189000
-
4 * 189000, SDS-PAGE
20000
Q877I4; Q877I3; Q877I5
4 * 62000 + 4 * 59000 + 4 * 20000, SDS-PAGE
200000
2000000
-
gel filtration enzyme exists in two polymeric forms of MW 2000000 and 10000000,interconvertible by phosphorylation and dephosphorylation. The 2000000 MW form predominates in preparations of unfrozen liver and is converted to the 10000000 MW form by dephosphorylation
206000
-
2 * 206000, SDS-PAGE
21000
-
x * 21000 + x * 31000 + x * 41000, phenol/acetic acid/urea gel
210000
219000
220000
225000
4 * 225000, recombinant enzyme, SDS-PAGE
227000
230000
238000
-
x * 238000, SDS-PAGE
240000
242530
-
x * 242530, calculation from nucleotide sequence
250000
250593
-
x * 250593, calculation from nucleotide sequence
251000
-
x * 251000, calculation from nucleotide sequence
252000
262000
-
SDS-PAGE
265000
272000
-
x * 272000, and a minor band at 265000 MW, hindlimb muscle, SDS-PAGE
279380
x * 279380, calculation from nucleotide sequence
280000
31000
-
x * 21000 + x * 31000 + x * 41000, phenol/acetic acid/urea gel
40000
-
x * 40000, 9686 enzyme, SDS-PAGE
41000
-
x * 21000 + x * 31000 + x * 41000, phenol/acetic acid/urea gel
420000
-
gel filtration, sucrose density gradient sedimentation
45000
-
x * 74000, alpha-subunit, + x * 45000, beta-subunit, SDS-PAGE
47000
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
480000
490000
-
native and recombinant carboxyltransferase subunit, gel filtration
500000
521000
-
gel filtration, diclofop-susceptible biotype
528000
540000
560000
gel filtration
57000
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
58000
-
x * 58000 + x * 65000 + x * 240000, SDS-PAGE
58100
-
carboxyltransferase subunit, calculated from amino acid sequence
59000
Q877I4; Q877I3; Q877I5
4 * 62000 + 4 * 59000 + 4 * 20000, SDS-PAGE
600000
-
greater than 600000 Da, gel filtration, complex from alpha and beta subunit of caroxyltransferase
610000
-
-
61500
-
biotin carboxylase subunit, calculated from amino acid sequence
62000
Q877I4; Q877I3; Q877I5
4 * 62000 + 4 * 59000 + 4 * 20000, SDS-PAGE
620000
-
gel filtration
65000
650000
-
gel filtration
650000 - 700000
-
about, plastidic enzyme form, gel filtration
66000
recombinant BC domain, gel filtration
700000
-
gel filtration
72000
-
x * 12000 + x * 47000 + x * 57000 + x * 72000, SDS-PAGE + 1% mercaptoethanol
74000
-
x * 74000, alpha-subunit, + x * 45000, beta-subunit, SDS-PAGE
740000
-
gel filtration
800000
-
greater than 800000 Da, gel filtration, complex from biotin carboxylase and biotin carboxyl carrier protein
840000
-
gel filtration
880000
approximately, recombinant enzyme, gel filtration
98000
-
x * 98000 + x * 240000, SDS-PAGE
additional information
-
linear polymers of MW several million