6.3.5.3: phosphoribosylformylglycinamidine synthase

This is an abbreviated version!
For detailed information about phosphoribosylformylglycinamidine synthase, go to the full flat file.

Reaction

Synonyms

2-Formamido-N-ribosylacetamide 5'-phosphate:L-glutamine amido-ligase (adenosine diphosphate), 5'-phosphoribosylformyl glycinamidine synthetase, FGAM, FGAM synthase, FGAM synthetase, FGAM-synthetase, FGAMS, FGAR amidotransferase, FGAR-AT, FGARAT, formylglycinamide ribonucleotide amidotransferase, formylglycinamide ribonucleotide amidotransferase complex, Formylglycinamide ribonucloetide amidotransferase, Formylglycinamide ribotide amidotransferase, Formylglycinamide ribotide synthetase, formylglycinamide synthetase, LT2, mPurL, ORF75c, PFAS, phosphoribosylformylglycinamidine synthase II, Phosphoribosylformylglycinamidine synthetase, Phosphoribosylformylglycineamidine synthetase, Pur4, PurL, PurS, smPurL, StPurL, Synthetase, phosphoribosylformylglycinamide, TmPurL

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

                6.3.5.3 phosphoribosylformylglycinamidine synthase

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Results	in table
75581	AA Sequence
2	Application
1	CAS Registry Number
13	Cloned(Commentary)
1	Cofactor
12	Crystallization (Commentary)
40	Disease/ Diagnostics
2	General Information
3	General Stability
26	Inhibitors
21	KM Value [mM]
4	Localization
13	Metals/Ions
11	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
38	Organism
8	Pathway
42	PDB ID
5	pH Optimum
3	pH Range
1	pH Stability
12	Protein Variants
9	Purification (Commentary)
7	Reaction
2	Reaction Type
38	Reference
27	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
42	Substrates and Products (Substrate)
4	Subunits
50	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 6.3.5.3 - phosphoribosylformylglycinamidine synthase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

42 - 80

Salmonella enterica subsp. enterica serovar Typhimurium

P74881

the first unfolding transition at 42°C leads to a loss of 15-20% of the secondary structure content of the protein and 80% loss in activity. The second unfolding transition at 80°C represents unfolding of the bulk of the protein

728631

50

Mus musculus

-

5 min, up to 98% loss of activity. A combination of Gln, MgCl2, and KCl protects against thermal inactivation

1669