6.3.5.3: phosphoribosylformylglycinamidine synthase

This is an abbreviated version!
For detailed information about phosphoribosylformylglycinamidine synthase, go to the full flat file.

Word Map on EC 6.3.5.3

6.3.5.3

purine

glutaminase

tegument

gammaherpesvirus

amidophosphoribosyltransferase

aminoimidazole

purinosome

acivicin

medicine

Reaction

N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide

2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine

Synonyms

2-Formamido-N-ribosylacetamide 5'-phosphate:L-glutamine amido-ligase (adenosine diphosphate), 5'-phosphoribosylformyl glycinamidine synthetase, FGAM, FGAM synthase, FGAM synthetase, FGAM-synthetase, FGAMS, FGAR amidotransferase, FGAR-AT, FGARAT, formylglycinamide ribonucleotide amidotransferase, formylglycinamide ribonucleotide amidotransferase complex, Formylglycinamide ribonucloetide amidotransferase, Formylglycinamide ribotide amidotransferase, Formylglycinamide ribotide synthetase, formylglycinamide synthetase, LT2, mPurL, ORF75c, PFAS, phosphoribosylformylglycinamidine synthase II, Phosphoribosylformylglycinamidine synthetase, Phosphoribosylformylglycineamidine synthetase, Pur4, PurL, PurS, smPurL, StPurL, Synthetase, phosphoribosylformylglycinamide, TmPurL

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.3.5.3 phosphoribosylformylglycinamidine synthase

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Results	in table
75581	AA Sequence
2	Application
1	CAS Registry Number
13	Cloned(Commentary)
1	Cofactor
12	Crystallization (Commentary)
40	Disease/ Diagnostics
2	General Information
3	General Stability
26	Inhibitors
21	KM Value [mM]
4	Localization
13	Metals/Ions
11	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
38	Organism
8	Pathway
42	PDB ID
5	pH Optimum
3	pH Range
1	pH Stability
12	Protein Variants
9	Purification (Commentary)
7	Reaction
2	Reaction Type
38	Reference
27	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
42	Substrates and Products (Substrate)
4	Subunits
50	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.5.3 - phosphoribosylformylglycinamidine synthase

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5'-phosphoribosylformylglycinamide + L-glutamine + ATP

phosphoribosylformylglycinamidine + L-glutamate + ADP + phosphate

Methanothermobacter thermautotrophicus

fourth step in the de novo purine biosynthetic pathway

653851

ATP + 5'-phosphoribosylformylglycinamide + L-Gln

2 entries

ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O

ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

2 entries

formylglycinamide ribonucleotide + ATP + L-glutamine + H2O

formylglycinamidine ribonucleotide + ADP + phosphate + L-glutamate

Salmonella enterica subsp. enterica serovar Typhimurium

fourth step of purine biosynthetic pathway

661077

additional information

2 entries