6.3.5.3: phosphoribosylformylglycinamidine synthase This is an abbreviated version! For detailed information about phosphoribosylformylglycinamidine synthase, go to the full flat file .
Reaction
ATP +
N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide +
L-glutamine +
H2O =
ADP +
phosphate +
2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine +
L-glutamate
Synonyms 2-Formamido-N-ribosylacetamide 5'-phosphate:L-glutamine amido-ligase (adenosine diphosphate), 5'-phosphoribosylformyl glycinamidine synthetase, FGAM, FGAM synthase, FGAM synthetase, FGAM-synthetase, FGAMS, FGAR amidotransferase, FGAR-AT, FGARAT, formylglycinamide ribonucleotide amidotransferase, formylglycinamide ribonucleotide amidotransferase complex, Formylglycinamide ribonucloetide amidotransferase, Formylglycinamide ribotide amidotransferase, Formylglycinamide ribotide synthetase, formylglycinamide synthetase, LT2, mPurL, ORF75c, PFAS, phosphoribosylformylglycinamidine synthase II, Phosphoribosylformylglycinamidine synthetase, Phosphoribosylformylglycineamidine synthetase, Pur4, PurL, PurS, smPurL, StPurL, Synthetase, phosphoribosylformylglycinamide, TmPurL
ECTree
Disease
Disease on EC 6.3.5.3 - phosphoribosylformylglycinamidine synthase
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Carcinoma
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3).
Carcinoma, Hepatocellular
In vivo inactivation of formylglycinamidine ribonucleotide synthetase in rat hepatoma.
Carcinoma, Hepatocellular
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Carcinoma, Hepatocellular
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3).
Carcinoma, Renal Cell
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3).
Herpes Simplex
Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons.
Infections
Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.
Infections
Multiple functions for ORF75c in murid herpesvirus-4 infection.
Infections
Murine gammaherpesvirus 68 encodes a second PML-modifying protein.
Infections
Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.
Leukemia
Murine gammaherpesvirus 68 encodes a second PML-modifying protein.
Leukemia
Murine gammaherpesvirus 68 ORF75c contains ubiquitin E3 ligase activity and requires PML SUMOylation but not other known cellular PML regulators, CK2 and E6AP, to mediate PML degradation.
Neoplasms
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Neoplasms
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3).
Neuroblastoma
Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons.
Protein Deficiency
Human phosphoribosylformylglycineamide amidotransferase (FGARAT): regional mapping, complete coding sequence, isolation of a functional genomic clone, and DNA sequence analysis.
Virus Diseases
Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons.
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