Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

6.3.5.3: phosphoribosylformylglycinamidine synthase

This is an abbreviated version!
For detailed information about phosphoribosylformylglycinamidine synthase, go to the full flat file.

Word Map on EC 6.3.5.3

Reaction

ATP
+
N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
 +
L-glutamine
 +
H2O
=
ADP
 +
phosphate
 +
2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine
 +
L-glutamate

Synonyms

2-Formamido-N-ribosylacetamide 5'-phosphate:L-glutamine amido-ligase (adenosine diphosphate), 5'-phosphoribosylformyl glycinamidine synthetase, FGAM, FGAM synthase, FGAM synthetase, FGAM-synthetase, FGAMS, FGAR amidotransferase, FGAR-AT, FGARAT, formylglycinamide ribonucleotide amidotransferase, formylglycinamide ribonucleotide amidotransferase complex, Formylglycinamide ribonucloetide amidotransferase, Formylglycinamide ribotide amidotransferase, Formylglycinamide ribotide synthetase, formylglycinamide synthetase, LT2, mPurL, ORF75c, PFAS, phosphoribosylformylglycinamidine synthase II, Phosphoribosylformylglycinamidine synthetase, Phosphoribosylformylglycineamidine synthetase, Pur4, PurL, PurS, smPurL, StPurL, Synthetase, phosphoribosylformylglycinamide, TmPurL

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
                6.3.5.3 phosphoribosylformylglycinamidine synthase

Molecular Weight

Molecular Weight on EC 6.3.5.3 - phosphoribosylformylglycinamidine synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
133000
-
1 * 133000, SDS-PAGE. When stored in absence of a reducing agent, e.g. DTT or 2-mercaptoethanol, the enzyme undergoes polymerization
133000 - 135000
141418
-
x * 141418, calculation from nucleotide sequence
24755
-
x * 24755, glutamine amide transfer subunit, + x * 80300, aminator subunit
80300
-
x * 24755, glutamine amide transfer subunit, + x * 80300, aminator subunit
additional information
-
PurL exists in two forms: large PurL (lgPurL) is a single chain, multidomain enzyme of about 1300 amino acids, whereas small PurL (smPurL) contains about 800 amino acids but requires two additional gene products, PurS and PurQ, for activity