6.3.5.3: phosphoribosylformylglycinamidine synthase

This is an abbreviated version!
For detailed information about phosphoribosylformylglycinamidine synthase, go to the full flat file.

Reaction

Synonyms

2-Formamido-N-ribosylacetamide 5'-phosphate:L-glutamine amido-ligase (adenosine diphosphate), 5'-phosphoribosylformyl glycinamidine synthetase, FGAM, FGAM synthase, FGAM synthetase, FGAM-synthetase, FGAMS, FGAR amidotransferase, FGAR-AT, FGARAT, formylglycinamide ribonucleotide amidotransferase, formylglycinamide ribonucleotide amidotransferase complex, Formylglycinamide ribonucloetide amidotransferase, Formylglycinamide ribotide amidotransferase, Formylglycinamide ribotide synthetase, formylglycinamide synthetase, LT2, mPurL, ORF75c, PFAS, phosphoribosylformylglycinamidine synthase II, Phosphoribosylformylglycinamidine synthetase, Phosphoribosylformylglycineamidine synthetase, Pur4, PurL, PurS, smPurL, StPurL, Synthetase, phosphoribosylformylglycinamide, TmPurL

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

                6.3.5.3 phosphoribosylformylglycinamidine synthase

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75581	AA Sequence
2	Application
1	CAS Registry Number
13	Cloned(Commentary)
1	Cofactor
12	Crystallization (Commentary)
40	Disease/ Diagnostics
2	General Information
3	General Stability
26	Inhibitors
21	KM Value [mM]
4	Localization
13	Metals/Ions
11	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
38	Organism
8	Pathway
42	PDB ID
5	pH Optimum
3	pH Range
1	pH Stability
12	Protein Variants
9	Purification (Commentary)
7	Reaction
2	Reaction Type
38	Reference
27	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
42	Substrates and Products (Substrate)
4	Subunits
50	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Reaction

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Reaction on EC 6.3.5.3 - phosphoribosylformylglycinamidine synthase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

5 entries

ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

ping-pong mechanism

Mus musculus

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1667, 1668, 1669

ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gln binds to the free enzyme and Glu is released before the addition of ATP. ADP is released, and phosphoribosyl-formylglycinamide then binds. The liberation of phosphate is rapid, and 5'-phosphoribosylformylglycinamidine is the last product released

Mus musculus

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1668

ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gln adds first to the enzyme with ATP and 5'-phosphoribosylformylglycinamide adding randomly subsequently

Gallus gallus

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1666

ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

substrates add sequentially to form a quarternary complex. Gln adds first with ATP and 5'-phosphoribosylformylglycinamide adding subsequently

Gallus gallus

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1665

ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

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