6.3.2.5: phosphopantothenate-cysteine ligase (CTP)
This is an abbreviated version!
For detailed information about phosphopantothenate-cysteine ligase (CTP), go to the full flat file.
Reaction
+
+
=
+
+
Synonyms
4’-phosphopantothenoylcysteine synthetase, CoaB, CoaBC, coupling enzyme, Dfp, pantothenate 4´-phosphate:L-cysteine ligase, phosphopantothenate-cysteine ligase, phosphopantothenoyl-cysteine ligase, phosphopantothenoylcysteine synthetase, PPC synthase, PPC synthetase, PPC-S, PPCS, synthetase, phosphopantothenoylcysteine
ECTree
KM Value
KM Value on EC 6.3.2.5 - phosphopantothenate-cysteine ligase (CTP)
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0.013 - 0.29
(R)-4'-phosphopantothenate
0.78
(R)-4'-phosphopantothenoyl-L-cysteine
-
pH 7.6
0.071 - 0.29
4'-phosphopantothenate
0.269
ATP
-
pH 7.6, 37°C
0.24
L-cysteine
-
at pH 7.6 and 25°C
0.78
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
at pH 7.6 and 25°C
additional information
additional information
-
enzyme shows cooperative binding of ATP, measured as a Hill constant of 1.7
-
0.013
(R)-4'-phosphopantothenate
-
co-substrate ATP, pH 7.6, 37°C
0.017
(R)-4'-phosphopantothenate
-
pH 7.6, 37°C
0.057
(R)-4'-phosphopantothenate
-
co-substrate CTP, pH 7.6, 37°C
0.29
(R)-4'-phosphopantothenate
-
at pH 7.6 and 25°C
0.071 - 0.083
4'-phosphopantothenate
-
37°C, pH 7.5
0.29
4'-phosphopantothenate
-
pH 7.6
0.156
CTP
-
pH 7.6, 37°C
0.265
CTP
-
pH 7.6, 37°C
0.29
CTP
-
at pH 7.6 and 25°C
0.014
L-Cys
-
co-substrate ATP, pH 7.6, 37°C
0.016
L-Cys
-
co-substrate CTP, pH 7.6, 37°C
0.086
L-Cys
-
pH 7.6, 37°C