6.3.2.5: phosphopantothenate-cysteine ligase (CTP)
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For detailed information about phosphopantothenate-cysteine ligase (CTP), go to the full flat file.
Reaction
Synonyms
4’-phosphopantothenoylcysteine synthetase, CoaB, CoaBC, coupling enzyme, Dfp, pantothenate 4´-phosphate:L-cysteine ligase, phosphopantothenate-cysteine ligase, phosphopantothenoyl-cysteine ligase, phosphopantothenoylcysteine synthetase, PPC synthase, PPC synthetase, PPC-S, PPCS, synthetase, phosphopantothenoylcysteine
ECTree
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Engineering
Engineering on EC 6.3.2.5 - phosphopantothenate-cysteine ligase (CTP)
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N210D
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complete loss of enzymic activity, but intermediate 4Â’-phosphopanthotenoyl-CMP is formed
K310Q
N217H
K310Q
N217H
additional information
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mutation in dPPCS impair female fecundity and fertility, and disrupts the organization of the somatic and germ line cells, affects F-actin organization and results in abnormal PtdIns(4,5)P2 localization. Improper cell organization coincides with aberrant localization of the membrane molecules Gurken (Grk) and Notch, whose activities are required for specification of the follicle cells that pattern the eggshell. Mutations in dPPCS also induce alterations in scutellar patterning and cause wing vein abnormalities, phenotype, detailed overview