6.3.2.5: phosphopantothenate-cysteine ligase (CTP)

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For detailed information about phosphopantothenate-cysteine ligase (CTP), go to the full flat file.

Reaction

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

Synonyms

4�-phosphopantothenoylcysteine synthetase, CoaB, CoaBC, coupling enzyme, Dfp, pantothenate 4�-phosphate:L-cysteine ligase, phosphopantothenate-cysteine ligase, phosphopantothenoyl-cysteine ligase, phosphopantothenoylcysteine synthetase, PPC synthase, PPC synthetase, PPC-S, PPCS, synthetase, phosphopantothenoylcysteine

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.5 phosphopantothenate-cysteine ligase (CTP)

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Results	in table
35953	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
3	Cofactor
2	Crystallization (Commentary)
11	Disease/ Diagnostics
3	General Information
14	Inhibitors
7	Ki Value [mM]
20	KM Value [mM]
2	Metals/Ions
6	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
27	Organism
6	Pathway
34	PDB ID
2	pH Optimum
18	Protein Variants
8	Purification (Commentary)
6	Reaction
2	Reaction Type
27	Reference
8	Source Tissue
3	Specific Activity [micromol/min/mg]
38	Substrates and Products (Substrate)
7	Subunits
27	Synonyms
1	Systematic Name
5	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.2.5 - phosphopantothenate-cysteine ligase (CTP)

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(R)-4'-phosphopantothenate:L-cysteine ligase

A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC 6.3.2.51, which requires ATP. Cysteine can be replaced by some of its derivatives.