6.3.2.5: phosphopantothenate-cysteine ligase (CTP)

This is an abbreviated version!
For detailed information about phosphopantothenate-cysteine ligase (CTP), go to the full flat file.

Reaction

Synonyms

4�-phosphopantothenoylcysteine synthetase, CoaB, CoaBC, coupling enzyme, Dfp, pantothenate 4�-phosphate:L-cysteine ligase, phosphopantothenate-cysteine ligase, phosphopantothenoyl-cysteine ligase, phosphopantothenoylcysteine synthetase, PPC synthase, PPC synthetase, PPC-S, PPCS, synthetase, phosphopantothenoylcysteine

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.5 phosphopantothenate-cysteine ligase (CTP)

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Results	in table
35953	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
3	Cofactor
2	Crystallization (Commentary)
11	Disease/ Diagnostics
3	General Information
14	Inhibitors
7	Ki Value [mM]
20	KM Value [mM]
2	Metals/Ions
6	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
27	Organism
6	Pathway
34	PDB ID
2	pH Optimum
18	Protein Variants
8	Purification (Commentary)
6	Reaction
2	Reaction Type
27	Reference
8	Source Tissue
3	Specific Activity [micromol/min/mg]
38	Substrates and Products (Substrate)
7	Subunits
27	Synonyms
1	Systematic Name
5	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.3.2.5 - phosphopantothenate-cysteine ligase (CTP)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

CTP + (R)-4'-phosphopantothenate + L-cysteine

Escherichia coli

-

-

648960

-

-

r

CTP + (R)-4'-phosphopantothenate + L-Cys

?

Micrococcus luteus

-

Brown´s pathway of CoA synthesis

4412

-

-

?

CTP + (R)-4'-phosphopantothenate + L-cysteine

CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

4 entries

CTP + (R)-4'-phosphopantothenate + L-cysteine

CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

Drosophila melanogaster

-

the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview

691514

-

-

?

CTP + (R)-4'-phosphopantothenate + L-cysteine

CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

Escherichia coli

-

-

648960

-

-

r

CTP + (R)-4'-phosphopantothenate + L-cysteine

CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

Methanocaldococcus jannaschii

Q58323

-

674749

-

-

?

CTP + (R)-4'-phosphopantothenate + L-cysteine

CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

Methanocaldococcus jannaschii DSM 2661

Q58323

-

674749

-

-

?