6.3.2.5: phosphopantothenate-cysteine ligase (CTP)
This is an abbreviated version!
For detailed information about phosphopantothenate-cysteine ligase (CTP), go to the full flat file.
Reaction
Synonyms
4’-phosphopantothenoylcysteine synthetase, CoaB, CoaBC, coupling enzyme, Dfp, pantothenate 4´-phosphate:L-cysteine ligase, phosphopantothenate-cysteine ligase, phosphopantothenoyl-cysteine ligase, phosphopantothenoylcysteine synthetase, PPC synthase, PPC synthetase, PPC-S, PPCS, synthetase, phosphopantothenoylcysteine
ECTree
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Reaction
Reaction on EC 6.3.2.5 - phosphopantothenate-cysteine ligase (CTP)
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CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
mechanism
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CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
ping pong mechanism
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CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
cysteine can be replaced by some of its derivatives
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CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
bi uni uni bi ping pong mechanism, with the nucleotide CTP binding first and CMP released last
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CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
bi uni uni bi ping pong mechanism. 18O from [carboxyl-18O] phosphopantothenate is incorporated into the AMP or CMP produced during PPCS catalysis, consistent with the formation of a phosphopantothenoyl cytidylate or phosphopantothenoyl adenylate intermediate, supporting similar catalytic mechanisms under both CTP and ATP conditions
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