5.4.4.2: isochorismate synthase

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For detailed information about isochorismate synthase, go to the full flat file.

Word Map on EC 5.4.4.2

5.4.4.2

corticosteroid

inhaled

asthma

children

pulmonary

long-acting

airway

labas

asthmatic

agonist

bronchodilator

placebo

fluticasone

eosinophil

expiratory

prescript

short-acting

double-blind

physician

bronchial

beta2-agonists

budesonide

spirometry

montelukast

add-on

wheezing

randomised

ketanserin

5-hydroxytryptamine

leukotriene

once-daily

muscarinic

monotherapy

salmeterol

sputum

5-ht-induced

urodynamic

parallel-group

methysergide

intercostal

fixed-dose

immunochromatographic

self-management

ondansetron

incontinence

real-life

drug development

8-oh-dpat

datalink

agriculture

airflow

run-in

Reaction

Synonyms

Amonabactin, AtICS1, AtICS2, DhbC, EC 5.4.99.6, Eds16, EntC, ICS, ICS1, ICS1 gene product, ICS2, IcsI, isochorismatase, isochorismate hydroxymutase, isochorismate mutase, isochorismate mutase 1, isochorismate mutase 2, isochorismate synthase, isochorismate synthase 1, isochorismate synthase 1, chloroplastic, isochorismate synthase 2, chloroplastic, Isochorismic synthase, MbtI, menaquinone-specific isochorismate synthase, MenF, PchA, salicylate biosynthesis isochorismate synthase, salicylate synthase, Sid2, Synthase, isochorismate

ECTree

5 Isomerases

5.4 Intramolecular transferases

5.4.4 Transferring hydroxy groups

5.4.4.2 isochorismate synthase

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Results	in table
3	Activating Compound
16820	AA Sequence
2	Application
1	CAS Registry Number
19	Cloned(Commentary)
5	Crystallization (Commentary)
11	Expression
45	General Information
4	General Stability
42	Inhibitors
14	kcat/KM [mM/s]
16	Ki Value [mM]
34	KM Value [mM]
11	Localization
22	Metals/Ions
12	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
64	Organism
12	Pathway
57	PDB ID
15	pH Optimum
3	pH Range
1	Posttranslational Modification
27	Protein Variants
14	Purification (Commentary)
6	Reaction
2	Reaction Type
58	Reference
22	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
70	Substrates and Products (Substrate)
18	Subunits
69	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
5	Temperature Range [°C]
2	Temperature Stability [°C]
24	Turnover Number [1/s]

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Application on EC 5.4.4.2 - isochorismate synthase

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agriculture

Carthamus tinctorius

the enzyme can be considered in plant breeding programs for salinity tolerance as well as for pathogen resistance for the oilseed industrial medical plant Carthamus tinctorius

728533

drug development

Mycobacterium tuberculosis

enzyme MbtI represents an appealing target for development of inhibitors of mycobactin biosynthesis since it is structurally and biochemically characterized, has no human orthologues, and is conditionally essential under iron-deficient conditions. Inhibitors are designed against the isochorismatase activity of the enzyme (EC 5.4.4.2)

748448