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(4R,5R)-4-hydroxy-5-(1-carboxyvinyloxy)-cyclohex-1-ene carboxylate
-
-
(4R,5R)-4-hydroxy-5-carboxymethoxy-cyclohex-1-enecarboxylate
-
-
(4R,5R)-5-(2-carboxy-allyloxy)-4-hydroxy-cyclohex-1-enecarboxylate
-
-
(4R,5R)-5-(carboxymethoxy)-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
(4R,5R)-5-[(1R)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5R)-5-[(1S)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5R)-5-[(2-carboxyprop-2-en-1-yl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5R,6S)-6-amino-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
(4R,5R,6S)-6-ammonio-5-[(1-carboxylatoethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylate
-
-
(4R,5R,7R)-5-(1-carboxy-ethoxy)-4-hydroxy-cyclohex-1-enecarboxylate
-
-
(4R,5R,7S)-5-(1-carboxy-ethoxy)-4-hydroxy-cyclohex-1-enecarboxylate
-
-
(4R,5S,6R)-4-amino-5-(2-carboxyethyl)-6-hydroxycyclohex-1-ene carboxylic acid
-
transition-state inhibitor
(4R,5S,6R)-4-amino-5-(2-carboxyethyl)-6-hydroxycyclohex-1-ene-1-carboxylic acid
-
-
-
(4R,5S,6S)-4-amino-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohex-1-ene-1-carboxylic acid
(4R,5S,6S)-4-ammonio-5-[(1-carboxylatoethenyl)oxy]-6-hydroxycyclohex-1-ene-1-carboxylate
-
-
(4R,5S,6S)-5-[(1-carboxyethenyl)oxy]-4,6-dihydroxycyclohex-1-ene-1-carboxylic acid
(4R,5S,6S)-5-[(1-carboxylatoethenyl)oxy]-4,6-dihydroxycyclohex-1-ene-1-carboxylate
-
-
(E)-1-(tert-butyldimethylsilyloxy)-1,3-butadiene
-
-
3-[[(1Z)-1-carboxyprop-1-en-1-yl]oxy]-2-hydroxybenzoic acid
-
-
benzimidazole-2-thione
-
noncompetitive inhibitor with
oseltamivir
-
i.e. Tamiflu
salicylic acid
-
treatment of plants suppresses the enhancement of enzyme expression by O3
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
inhibition of isochorismate synthase activity and salicylate synthase activity
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
-
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
-
(4R,5R,6S)-6-amino-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5R,6S)-6-amino-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5S,6S)-4-amino-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5S,6S)-4-amino-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5S,6S)-5-[(1-carboxyethenyl)oxy]-4,6-dihydroxycyclohex-1-ene-1-carboxylic acid
-
(4R,5S,6S)-5-[(1-carboxyethenyl)oxy]-4,6-dihydroxycyclohex-1-ene-1-carboxylic acid
-
additional information
inhibitor structure-function relationship and molecular docking
-
additional information
inhibitor structure-function realtionship and molecular docking
-
additional information
-
design, synthesis and biochemical evaluation of inhibitor 4 based on the putative transition-state (TS) for the isochorismatase partial reaction of MbtI. The inhibitor mimics the hypothesized charge build-up at C-4 of chorismate in the TS as well as C-O bond-formation at C-6. Another important design element of the inhibitor is replacement of the labile pyruvate side-chain in chorismate with a stable C-linked propionate isostere. Development of a stereocontrolled synthesis of the highly functionalized cyclohexene inhibitor that features an asymmetric aldol reaction using a titanium enolate, diastereoselective Grignard addition to a tert-butanesulfinyl aldimine, and ring closing olefin metathesis as key steps
-
additional information
inhibitor structure-function relationship and molecular docking
-
additional information
-
inhibitor structure-function relationship and molecular docking
-
additional information
-
inhibitor structure-function relationship and molecular docking
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evolution
-
PchA is a member of the MST, i.e. menaquinone, siderophore and tryptophan, family of enzymes
evolution
genes ATICS1 and AtICS2 are both located on chromosome 1 on different sides of the centromere, and they are likely a result of a duplication event, since they are bordered by similar genes. At the DNA sequence level, the protein-coding regions of the two genes share a high degree of similarity, but this does not extend into the untranslated regions
evolution
-
the predicted ICS protein has high amino acid sequence identity to its orthologues and possesses a conserved chorismate binding site belonging to the supergene family of chorismate binding proteins
malfunction
the redox status of the plastoquinone pool in knockout mutant ics1 shows significant variation depending on the leaf age. Mutant plants treated with a phylloquinone precursor display symptoms of phenotypic reversion towards the wild type. The ics1 mutant also shows altered thylakoid structure with an increased number of stacked thylakoids per granum
malfunction
mutation sed111 in the gene salicylic acid induction-deficient 2 (SID2), which encodes isochorismate synthase 1. Mutation sed111 belongs to a series of mutants called suppressor of esd4 (sed), which delay flowering, enhance growth and reduce hyperaccumulation of SUMO conjugates. Mutations in the SUMO protease early in short days 4 (ESD4) cause hyperaccumulation of conjugates formed between SUMO and its substrates, and phenotypically are associated with extreme early flowering and impaired growth. Elevated salicylic acid levels conferred by increased expression of isochorismate synthase 1 contribute to hyperaccumulation of SUMO1 conjugates in the Arabidopsis thaliana mutant early in short days 4. Compared to wild-type plants, esd4 contains higher levels of SID2 mRNA and about threefold more salicylate, whereas sed111 contains lower salicylate levels
malfunction
significant reduction in the expression of ICS1 during immune responses is observed in the tcp8/tcp9 double mutant
malfunction
-
the redox status of the plastoquinone pool in knockout mutant ics1 shows significant variation depending on the leaf age. Mutant plants treated with a phylloquinone precursor display symptoms of phenotypic reversion towards the wild type. The ics1 mutant also shows altered thylakoid structure with an increased number of stacked thylakoids per granum
-
malfunction
-
significant reduction in the expression of ICS1 during immune responses is observed in the tcp8/tcp9 double mutant
-
metabolism
-
key enzyme in the isochorismate pathway
metabolism
-
the enzyme produces isochorismate for conversion to salicylate by isochorismate-pyruvate lyase, PchB, and incorporation into the pyochelin siderophore. Isochorismate synthase (PchA) and isochorismate-pyruvate lyase (PchB) from Pseudomonas aeurginosa are involved in the synthesis of the siderophore pyochelin
metabolism
enzyme ICS does not act as isochorismate pyruvate lyase (IPL, EC 4.2.99.21) and bifunctional salicylate synthase, it does not convert chorismate into salicylate. In Arabidopsis thaliana, salicylate is synthesized from chorismic acid, derived from the shikimic acid pathway, occuring in the plastid
metabolism
isochorismate synthase 1 is a key enzyme in salicylate biosynthesis in Arabidopsis thaliana. The TCP family transcription factor AtTCP8 is a regulator of isozyme ICS1, it binds to a typical TCP binding site in the ICS1 promoter. Expression patterns of TCP8 and its corresponding gene TCP9 largely overlap with ICS1 under pathogen attack. Strong interactions between TCP8 and SAR deficient 1 (SARD1), WRKY family transcription factor 28 (WRKY28), NAC (NAM/ATAF1, ATAF2/CUC2) family transcription factor 019 (NAC019), as well as among TCP8, TCP9 and TCP20, implying a complex coordinated regulatory mechanism underlying ICS1 expression. There is a strong negative regulatory region between -128 and -316 bp, and the binding of repressor(s) to this region may be necessary for suppression of ICS1 expression during plant growth and development, TCP8 can bind at this region, while TCP5, TCP11 and TCP19 appear not to bind to the promoter region. TCP8 specifically binds to the TCP binding site in the ICS1 promoter in vitro and in vivo. Trans-activation capability of TCP8. TCP8/TCP9 positively regulate ICS1 expression with redundancy upon pathogen infection, and TCPs are involved in maintaining ICS1 expression, yeast one-hybrid (Y1H) screening and transactivation activity assay, detailed overview
metabolism
-
salicylic acid is synthesized via the phenylalanine lyase (PAL) and isochorismate synthase (ICS) pathways and can influence the stress response in plants by regulating certain secondary metabolites. Both free salicylate and total salicylate are positively correlated with PAL, ICS, and baicalin, but negatively correlated with baicalein, overview
metabolism
-
the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities
metabolism
the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). Salicylate synthase converts chorismate into salicylate through a two-step reaction
metabolism
the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). Salicylate synthase converts chorismate into salicylate through a two-step reaction
metabolism
-
the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities
metabolism
-
the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities
metabolism
the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities
metabolism
-
isochorismate synthase 1 is a key enzyme in salicylate biosynthesis in Arabidopsis thaliana. The TCP family transcription factor AtTCP8 is a regulator of isozyme ICS1, it binds to a typical TCP binding site in the ICS1 promoter. Expression patterns of TCP8 and its corresponding gene TCP9 largely overlap with ICS1 under pathogen attack. Strong interactions between TCP8 and SAR deficient 1 (SARD1), WRKY family transcription factor 28 (WRKY28), NAC (NAM/ATAF1, ATAF2/CUC2) family transcription factor 019 (NAC019), as well as among TCP8, TCP9 and TCP20, implying a complex coordinated regulatory mechanism underlying ICS1 expression. There is a strong negative regulatory region between -128 and -316 bp, and the binding of repressor(s) to this region may be necessary for suppression of ICS1 expression during plant growth and development, TCP8 can bind at this region, while TCP5, TCP11 and TCP19 appear not to bind to the promoter region. TCP8 specifically binds to the TCP binding site in the ICS1 promoter in vitro and in vivo. Trans-activation capability of TCP8. TCP8/TCP9 positively regulate ICS1 expression with redundancy upon pathogen infection, and TCPs are involved in maintaining ICS1 expression, yeast one-hybrid (Y1H) screening and transactivation activity assay, detailed overview
-
metabolism
-
the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities
-
physiological function
-
Arabidopsis ICS1 represents a divergent isoform for inducible salicylic acid synthesis during defense
physiological function
-
Populus ICS primarily functions in phylloquinone biosynthesis
physiological function
-
Populus ICS primarily functions in phylloquinone biosynthesis
physiological function
Q81QQ0
the enzyme is essential for the biosynthesis of the siderophore bacillibactin by the pathogenic bacterium
physiological function
the enzyme is required for the appropriate hypersensitive disease defence response. It also takes part in the synthesis of phylloquinone, which is incorporated into photosystem I and is an important component of photosynthetic electron transport in plants role of ICS1 in regulation of state transition. Role of ICS1 in integration of the chloroplast ultrastructure, the redox status of the plastoquinone pool, and organization of the photosystems, which all are important for optimal immune defence and light acclimatory responses
physiological function
chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria
physiological function
isochorismate synthase 1 is required for salicylate biosynthesis. SUMO homeostasis influences salicylate biosynthesis in wild-type plants, and also demonstrate that elevated levels of salicylate strongly increase the abundance of SUMO conjugates
physiological function
isozyme AtICS1 is required for increased salicylate biosynthesis in response to pathogens, and its expression can be stimulated throughout the leaf by virus infection and exogenous salicylate. Isozymes AtICS1 and AtICS2 can be successful in competing for chorismate in vivo
physiological function
isozymes AtICS1 and AtICS2 can be successful in competing for chorismate in vivo
physiological function
-
mycobactins are small-molecule iron chelators (siderophores) produced by Mycobacterium tuberculosis (Mtb) for iron mobilization. Siderophores are small-molecule iron chelators that scavenge iron from host tissues and uptake of heme through a specialized heme receptor followed by heme degradation to release the iron. The bifunctional salicylate synthase MbtI catalyzes the first step of mycobactin biosynthesis through the conversion of the primary metabolite chorismate into salicylic acid via isochorismate
physiological function
the enzyme is involved in the biosynthesis of pyochelin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria
physiological function
the enzyme is involved in the biosynthesis of the siderophore mycobactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria
physiological function
-
the enzyme is involved in the biosynthesis of the siderophore yersiniabactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria
physiological function
-
the enzyme is involved in the biosynthesis of the siderophore yersiniabactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria
physiological function
-
the enzyme is essential for the biosynthesis of the siderophore bacillibactin by the pathogenic bacterium
-
physiological function
-
the enzyme is required for the appropriate hypersensitive disease defence response. It also takes part in the synthesis of phylloquinone, which is incorporated into photosystem I and is an important component of photosynthetic electron transport in plants role of ICS1 in regulation of state transition. Role of ICS1 in integration of the chloroplast ultrastructure, the redox status of the plastoquinone pool, and organization of the photosystems, which all are important for optimal immune defence and light acclimatory responses
-
physiological function
-
the enzyme is involved in the biosynthesis of the siderophore mycobactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria
-
additional information
Q81QQ0
enzyme structure comparisons and analysis, active site structure, overview. Ala304 plays an important role in positioning the peptide-bond carbonyl, enabling the formation of a proper hydrogen bond to the isochorismate C2 hydroxyl
additional information
-
enzyme structure comparisons and analysis, active site structure, overview. Ala304 plays an important role in positioning the peptide-bond carbonyl, enabling the formation of a proper hydrogen bond to the isochorismate C2 hydroxyl
additional information
-
solvent kinetic isotope effects, overview
additional information
-
structure-function relationships of chorismate-utilizing enzymes, structure comparisons, overview. Isochorismate synthase cannot perform any pericyclic reaction. Residues K221 and E269 are general base and acid, respectively
additional information
enzyme three-dimensional structure analysis, the lysine residue, Lys190, might be involved in the activation of water molecules and the subsequent nucleophilic attack on the C2 carbon of chorismate without directly involving the magnesium ion, participation of the Lys residue during the activation of the substrate or nucleophilic agent
additional information
enzyme three-dimensional structure analysis, the lysine residue, Lys190, might be involved in the activation of water molecules and the subsequent nucleophilic attack on the C2 carbon of chorismate without directly involving the magnesium ion, participation of the Lys residue during the activation of the substrate or nucleophilic agent
additional information
homology modeling of isozymes ICS1 and ICS2 using Serratia marcescens anthranilate synthase (TrpE, PDB ID 1I7Q) as reference structure
additional information
homology modeling of isozymes ICS1 and ICS2 using Serratia marcescens anthranilate synthase (TrpE, PDB ID 1I7Q) as reference structure
additional information
-
homology modeling of isozymes ICS1 and ICS2 using Serratia marcescens anthranilate synthase (TrpE, PDB ID 1I7Q) as reference structure
additional information
-
enzyme structure comparisons and analysis, active site structure, overview. Ala304 plays an important role in positioning the peptide-bond carbonyl, enabling the formation of a proper hydrogen bond to the isochorismate C2 hydroxyl
-
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Young, I.G.; Gibson, F.
Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli
Biochim. Biophys. Acta
177
401-411
1969
Klebsiella aerogenes
brenda
Liu, J.; Quinn, N.; Berchthold, G.A.; Walsh, C.T.
Overexpression, purification, and characterization of isochorismate synthase (EnrC), the first enzyme involved in the biosynthesis of Enterobactin from Chorismate
Biochemistry
29
1417-1425
1990
Escherichia coli
brenda
Daruwala, R.; Bhattacharyya, D.K.; Kwon, O.; Meganathan, R.
Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and characterization of a new isochorismate synthase from Escherichia coli
J. Bacteriol.
179
3133-3138
1997
Escherichia coli
brenda
Rowland, B.M.; Taber, H.W.
Duplicate isochorismate synthase genes of Bacillus subtilis: regulation and involvement in the biosynthesis of menaquinone and 2,3-dihydroxybenzoate
J. Bacteriol.
178
854-861
1996
Bacillus subtilis
brenda
Schaaf, P.M.M.; Heide, L.E.; Leistner, E.W.; Tani, Y.; El-Olemy, M.M.
Immobilization of isochorismate hydroxymutase. Comparison of native versus immobilized enzyme
J. Nat. Prod.
56
1304-1312
1993
Flavobacterium sp., Flavobacterium sp. K3-15
brenda
Schaaf, P.M.; Heide, L.E.; Leistner, E.W.; Tani, Y.; Karas, M.; Deutzmann, R.
Properties of isochorismate hydroxymutase from Flavobacterium K3-15
J. Nat. Prod.
56
1294-1303
1993
Klebsiella aerogenes, Escherichia coli, Flavobacterium sp., Flavobacterium sp. 238-7, Flavobacterium sp. K3-15
brenda
Poulsen, C.; van der Heijden, R.; Verpoorte, R.
Assay of isochorismate synthase from plant cell cultures by high-performance liquid chromatography
Phytochemistry
30
2873-2876
1991
Morinda citrifolia, Rubia tinctorum
-
brenda
Leduc, C.; Ruhnau, P.; Leistner, E.
Isochorismate hydroxymutase from Rubiaceae cell suspension culture
Plant Cell Rep.
10
334-337
1991
Galium mollugo, Galium uliginosum, Morinda lucida
brenda
Leduc, C.; Birgel, R.; Muller, R.; Leistner, E.
Isochorismate hydroxymutase from a cell-suspension culture of Galium mollugo L.
Planta
202
206-210
1997
Galium mollugo
-
brenda
Daruwala, R.; Kwon, O.; Meganathan, R.; Hudspeth, M.E.S.
A new isochorismate synthase specifically involved in menaquinone (vitamin K2) biosynthesis encoded by the menF gene
FEMS Microbiol. Lett.
140
159-163
1996
Escherichia coli
brenda
Zamir, L.O.; Devor, K.A.; Jensen, R.A.; Tiberio, R.; Sauriol, F.; Mamer, O.
Biosynthesis of isochorismate in Klebsiella pneumonia: origin of O-2
Can. J. Microbiol.
37
276-280
1991
Klebsiella aerogenes
brenda
Muller, R.; Dahm, C.; Schulte, G.; Leistner, E.
An isochorismate hydroxymutase isogene in Escherichia coli
FEBS Lett.
378
131-134
1996
Escherichia coli
brenda
Gaille, C.; Reimmann, C.; Haas, D.
Isochorismate synthase (PchA), the first and rate-limiting enzyme in salicylate biosynthesis of Pseudomonas aeruginosa
J. Biol. Chem.
278
16893-16898
2003
Pseudomonas aeruginosa (Q51508), Pseudomonas aeruginosa
brenda
Harrison, A.J.; Ramsay, R.J.; Baker, E.N.; Lott, J.S.
Crystallization and preliminary x-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
F61
121-123
2005
Mycobacterium tuberculosis
brenda
Wildermuth, M.C.; Dewdney, J.; Wu, G.; Ausubel, F.M.
Isochorismate synthase is required to synthesize salicylic acid for plant defence
Nature
414
562-565
2001
Cyanidium caldarium, Glycine max, Arabidopsis thaliana (Q9S7H8)
brenda
Ogawa, D.; Nakajima, N.; Sano, T.; Tamaoki, M.; Aono, M.; Kubo, A.; Kanna, M.; Ioki, M.; Kamada, H.; Saji, H.
Salicylic acid accumulation under O3 exposure is regulated by ethylene in tobacco plants
Plant Cell Physiol.
46
1062-1072
2005
Arabidopsis thaliana
brenda
Kolappan, S.; Zwahlen, J.; Zhou, R.; Truglio, J.J.; Tonge, P.J.; Kisker, C.
Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family
Biochemistry
46
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Arabidopsis thaliana (Q9S7H8)
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Arabidopsis thaliana (Q9S7H8), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9S7H8)
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Su, H.; Song, S.; Yan, X.; Fang, L.; Zeng, B.; Zhu, Y.
Endogenous salicylic acid shows different correlation with baicalin and baicalein in the medicinal plant Scutellaria baicalensis Georgi subjected to stress and exogenous salicylic acid
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Scutellaria baicalensis
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