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5.4.4.2: isochorismate synthase

This is an abbreviated version!
For detailed information about isochorismate synthase, go to the full flat file.

Word Map on EC 5.4.4.2

Reaction

chorismate
=
isochorismate

Synonyms

Amonabactin, AtICS1, AtICS2, DhbC, EC 5.4.99.6, Eds16, EntC, ICS, ICS1, ICS1 gene product, ICS2, IcsI, isochorismatase, isochorismate hydroxymutase, isochorismate mutase, isochorismate mutase 1, isochorismate mutase 2, isochorismate synthase, isochorismate synthase 1, isochorismate synthase 1, chloroplastic, isochorismate synthase 2, chloroplastic, Isochorismic synthase, MbtI, menaquinone-specific isochorismate synthase, MenF, PchA, salicylate biosynthesis isochorismate synthase, salicylate synthase, Sid2, Synthase, isochorismate

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.4 Transferring hydroxy groups
                5.4.4.2 isochorismate synthase

Reference

topprint

Reference on EC 5.4.4.2 - isochorismate synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Young, I.G.; Gibson, F.
Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli
Biochim. Biophys. Acta
177
401-411
1969
Klebsiella aerogenes
Manually annotated by BRENDA team
Liu, J.; Quinn, N.; Berchthold, G.A.; Walsh, C.T.
Overexpression, purification, and characterization of isochorismate synthase (EnrC), the first enzyme involved in the biosynthesis of Enterobactin from Chorismate
Biochemistry
29
1417-1425
1990
Escherichia coli
Manually annotated by BRENDA team
Daruwala, R.; Bhattacharyya, D.K.; Kwon, O.; Meganathan, R.
Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and characterization of a new isochorismate synthase from Escherichia coli
J. Bacteriol.
179
3133-3138
1997
Escherichia coli
Manually annotated by BRENDA team
Rowland, B.M.; Taber, H.W.
Duplicate isochorismate synthase genes of Bacillus subtilis: regulation and involvement in the biosynthesis of menaquinone and 2,3-dihydroxybenzoate
J. Bacteriol.
178
854-861
1996
Bacillus subtilis
Manually annotated by BRENDA team
Schaaf, P.M.M.; Heide, L.E.; Leistner, E.W.; Tani, Y.; El-Olemy, M.M.
Immobilization of isochorismate hydroxymutase. Comparison of native versus immobilized enzyme
J. Nat. Prod.
56
1304-1312
1993
Flavobacterium sp., Flavobacterium sp. K3-15
Manually annotated by BRENDA team
Schaaf, P.M.; Heide, L.E.; Leistner, E.W.; Tani, Y.; Karas, M.; Deutzmann, R.
Properties of isochorismate hydroxymutase from Flavobacterium K3-15
J. Nat. Prod.
56
1294-1303
1993
Klebsiella aerogenes, Escherichia coli, Flavobacterium sp., Flavobacterium sp. 238-7, Flavobacterium sp. K3-15
Manually annotated by BRENDA team
Poulsen, C.; van der Heijden, R.; Verpoorte, R.
Assay of isochorismate synthase from plant cell cultures by high-performance liquid chromatography
Phytochemistry
30
2873-2876
1991
Morinda citrifolia, Rubia tinctorum
-
Manually annotated by BRENDA team
Leduc, C.; Ruhnau, P.; Leistner, E.
Isochorismate hydroxymutase from Rubiaceae cell suspension culture
Plant Cell Rep.
10
334-337
1991
Galium mollugo, Galium uliginosum, Morinda lucida
Manually annotated by BRENDA team
Leduc, C.; Birgel, R.; Muller, R.; Leistner, E.
Isochorismate hydroxymutase from a cell-suspension culture of Galium mollugo L.
Planta
202
206-210
1997
Galium mollugo
-
Manually annotated by BRENDA team
Daruwala, R.; Kwon, O.; Meganathan, R.; Hudspeth, M.E.S.
A new isochorismate synthase specifically involved in menaquinone (vitamin K2) biosynthesis encoded by the menF gene
FEMS Microbiol. Lett.
140
159-163
1996
Escherichia coli
Manually annotated by BRENDA team
Zamir, L.O.; Devor, K.A.; Jensen, R.A.; Tiberio, R.; Sauriol, F.; Mamer, O.
Biosynthesis of isochorismate in Klebsiella pneumonia: origin of O-2
Can. J. Microbiol.
37
276-280
1991
Klebsiella aerogenes
Manually annotated by BRENDA team
Muller, R.; Dahm, C.; Schulte, G.; Leistner, E.
An isochorismate hydroxymutase isogene in Escherichia coli
FEBS Lett.
378
131-134
1996
Escherichia coli
Manually annotated by BRENDA team
Gaille, C.; Reimmann, C.; Haas, D.
Isochorismate synthase (PchA), the first and rate-limiting enzyme in salicylate biosynthesis of Pseudomonas aeruginosa
J. Biol. Chem.
278
16893-16898
2003
Pseudomonas aeruginosa (Q51508), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Harrison, A.J.; Ramsay, R.J.; Baker, E.N.; Lott, J.S.
Crystallization and preliminary x-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
F61
121-123
2005
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Wildermuth, M.C.; Dewdney, J.; Wu, G.; Ausubel, F.M.
Isochorismate synthase is required to synthesize salicylic acid for plant defence
Nature
414
562-565
2001
Cyanidium caldarium, Glycine max, Arabidopsis thaliana (Q9S7H8)
Manually annotated by BRENDA team
Ogawa, D.; Nakajima, N.; Sano, T.; Tamaoki, M.; Aono, M.; Kubo, A.; Kanna, M.; Ioki, M.; Kamada, H.; Saji, H.
Salicylic acid accumulation under O3 exposure is regulated by ethylene in tobacco plants
Plant Cell Physiol.
46
1062-1072
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Kolappan, S.; Zwahlen, J.; Zhou, R.; Truglio, J.J.; Tonge, P.J.; Kisker, C.
Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family
Biochemistry
46
946-953
2007
Escherichia coli (P38051), Escherichia coli
Manually annotated by BRENDA team
Strawn, M.A.; Marr, S.K.; Inoue, K.; Inada, N.; Zubieta, C.; Wildermuth, M.C.
Arabidopsis isochorismate synthase functional in pathogen-induced salicylate biosynthesis exhibits properties consistent with a role in diverse stress responses
J. Biol. Chem.
282
5919-5933
2007
Arabidopsis thaliana (Q9S7H8), Arabidopsis thaliana
Manually annotated by BRENDA team
Ogawa, D.; Nakajima, N.; Tamaoki, M.; Aono, M.; Kubo, A.; Kamada, H.; Saji, H.
The isochorismate pathway is negatively regulated by salicylic acid signaling in O3-exposed Arabidopsis
Planta
226
1277-1285
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Parsons, J.F.; Shi, K.M.; Ladner, J.E.
Structure of isochorismate synthase in complex with magnesium
Acta Crystallogr. Sect. D
64
607-610
2008
Escherichia coli (P38051)
Manually annotated by BRENDA team
Catinot, J.; Buchala, A.; Abou-Mansour, E.; Metraux, J.P.
Salicylic acid production in response to biotic and abiotic stress depends on isochorismate in Nicotiana benthamiana
FEBS Lett.
582
473-478
2008
Nicotiana benthamiana (A9LS51), Nicotiana benthamiana
Manually annotated by BRENDA team
Garcion, C.; Lohmann, A.; Lamodiere, E.; Catinot, J.; Buchala, A.; Doermann, P.; Metraux, J.P.
Characterization and biological function of the ISOCHORISMATE SYNTHASE2 gene of Arabidopsis
Plant Physiol.
147
1279-1287
2008
Arabidopsis thaliana (Q9M9V6)
Manually annotated by BRENDA team
Sridharan, S.; Howard, N.; Kerbarh, O.; B?aszczyk, M.; Abell, C.; Blundell, T.L.
Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes
J. Mol. Biol.
397
290-300
2010
Escherichia coli (P0AEJ2), Escherichia coli
Manually annotated by BRENDA team
Zhang, X.; Chen, S.; Mou, Z.
Nuclear localization of NPR1 is required for regulation of salicylate tolerance, isochorismate synthase 1 expression and salicylate accumulation in Arabidopsis
J. Plant Physiol.
167
144-148
2010
Arabidopsis thaliana
Manually annotated by BRENDA team
Payne, R.J.; Bulloch, E.M.; Toscano, M.M.; Jones, M.A.; Kerbarh, O.; Abell, C.
Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes
Org. Biomol. Chem.
7
2421-2429
2009
Escherichia coli
Manually annotated by BRENDA team
Yuan, Y.; Chung, J.D.; Fu, X.; Johnson, V.E.; Ranjan, P.; Booth, S.L.; Harding, S.A.; Tsai, C.J.
Alternative splicing and gene duplication differentially shaped the regulation of isochorismate synthase in Populus and Arabidopsis
Proc. Natl. Acad. Sci. USA
106
22020-22025
2009
Arabidopsis thaliana, Populus fremontii x Populus angustifolia, Populus tremuloides
Manually annotated by BRENDA team
Simoh, S.; Linthorst, H.J.; Lefeber, A.W.; Erkelens, C.; Kim, H.K.; Choi, Y.H.; Verpoorte, R.
Metabolic changes of Brassica rapa transformed with a bacterial isochorismate synthase gene
J. Plant Physiol.
167
1525-1532
2010
Escherichia coli
Manually annotated by BRENDA team
Domagalski, M.J.; Tkaczuk, K.L.; Chruszcz, M.; Skarina, T.; Onopriyenko, O.; Cymborowski, M.; Grabowski, M.; Savchenko, A.; Minor, W.
Structure of isochorismate synthase DhbC from Bacillus anthracis
Acta Crystallogr. Sect. F
69
956-961
2013
Bacillus anthracis (Q81QQ0), Bacillus anthracis, Bacillus anthracis Ames (Q81QQ0)
Manually annotated by BRENDA team
Meneely, K.M.; Luo, Q.; Dhar, P.; Lamb, A.L.
Lysine221 is the general base residue of the isochorismate synthase from Pseudomonas aeruginosa (PchA) in a reaction that is diffusion limited
Arch. Biochem. Biophys.
538
49-56
2013
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Lamb, A.L.
Pericyclic reactions catalyzed by chorismate-utilizing enzymes
Biochemistry
50
7476-7483
2011
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Gawronski, P.; Gorecka, M.; Bederska, M.; Rusaczonek, A.; Slesak, I.; Kruk, J.; Karpinski, S.
Isochorismate synthase 1 is required for thylakoid organization, optimal plastoquinone redox status, and state transitions in Arabidopsis thaliana
J. Exp. Bot.
64
3669-3679
2013
Arabidopsis thaliana (Q9S7H8), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9S7H8)
Manually annotated by BRENDA team
Sadeghi, M.; Dehghan, S.; Fischer, R.; Wenzel, U.; Vilcinskas, A.; Kavousi, H.; Rahnamaeian, M.
Isolation and characterization of isochorismate synthase and cinnamate 4-hydroxylase during salinity stress, wounding, and salicylic acid treatment in Carthamus tinctorius
Plant Signal. Behav.
8
e27335 1-9
2013
Carthamus tinctorius
Manually annotated by BRENDA team
Macaulay, K.M.; Heath, G.A.; Ciulli, A.; Murphy, A.M.; Abell, C.; Carr, J.P.; Smith, A.G.
The biochemical properties of the two Arabidopsis thaliana isochorismate synthases
Biochem. J.
474
1579-1590
2017
Arabidopsis thaliana (Q9M9V6), Arabidopsis thaliana (Q9S7H8), Arabidopsis thaliana
Manually annotated by BRENDA team
Svarcova, M.; Kratky, M.; Vinsova, J.
Investigation of potential inhibitors of chorismate-utilizing enzymes
Curr. Med. Chem.
22
1383-1399
2015
no activity in Homo sapiens, Yersinia pestis, Yersinia enterocolitica, Escherichia coli (P38051), Mycobacterium tuberculosis (P9WFX1), Pseudomonas aeruginosa (Q51508)
Manually annotated by BRENDA team
Liu, Z.; Liu, F.; Aldrich, C.C.
Stereocontrolled synthesis of a potential transition-state inhibitor of the salicylate synthase MbtI from Mycobacterium tuberculosis
J. Org. Chem.
80
6545-6552
2015
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Villajuana-Bonequi, M.; Elrouby, N.; Nordstroem, K.; Griebel, T.; Bachmair, A.; Coupland, G.
Elevated salicylic acid levels conferred by increased expression of isochorismate synthase 1 contribute to hyperaccumulation of SUMO1 conjugates in the Arabidopsis mutant early in short days 4
Plant J.
79
206-219
2014
Arabidopsis thaliana (Q9S7H8)
Manually annotated by BRENDA team
Wang, X.; Gao, J.; Zhu, Z.; Dong, X.; Wang, X.; Ren, G.; Zhou, X.; Kuai, B.
TCP transcription factors are critical for the coordinated regulation of isochorismate synthase 1 expression in Arabidopsis thaliana
Plant J.
82
151-162
2015
Arabidopsis thaliana (Q9S7H8), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q9S7H8)
Manually annotated by BRENDA team
Su, H.; Song, S.; Yan, X.; Fang, L.; Zeng, B.; Zhu, Y.
Endogenous salicylic acid shows different correlation with baicalin and baicalein in the medicinal plant Scutellaria baicalensis Georgi subjected to stress and exogenous salicylic acid
PLoS ONE
13
e0192114
2018
Scutellaria baicalensis
Manually annotated by BRENDA team