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5.4.4.2: isochorismate synthase

This is an abbreviated version!
For detailed information about isochorismate synthase, go to the full flat file.

Word Map on EC 5.4.4.2

Reaction

chorismate
=
isochorismate

Synonyms

Amonabactin, AtICS1, AtICS2, DhbC, EC 5.4.99.6, Eds16, EntC, ICS, ICS1, ICS1 gene product, ICS2, IcsI, isochorismatase, isochorismate hydroxymutase, isochorismate mutase, isochorismate mutase 1, isochorismate mutase 2, isochorismate synthase, isochorismate synthase 1, isochorismate synthase 1, chloroplastic, isochorismate synthase 2, chloroplastic, Isochorismic synthase, MbtI, menaquinone-specific isochorismate synthase, MenF, PchA, salicylate biosynthesis isochorismate synthase, salicylate synthase, Sid2, Synthase, isochorismate

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.4 Transferring hydroxy groups
                5.4.4.2 isochorismate synthase

Expression

Expression on EC 5.4.4.2 - isochorismate synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a significant reduction in the expression of ICS1 during immune responses is observed in the tcp8 tcp9 double mutant. There is a strong negative regulatory region between -128 and -316 bp, and the binding of repressor(s) to this region may be necessary for suppression of ICS1 expression during plant growth and development, TCP8 can bind at this region, while TCP5, TCP11 and TCP19 appear not to bind to the promoter region. TCP8 specifically binds to the TCP binding site in the ICS1 promoter in vitro and in vivo
elevated salicylic acid levels confer increased expression of isochorismate synthase 1, ICS1
expression of ICS is downregulated significantly by 67% under drought stress. ICS gene expression is upregulated after 0.140 mM salicylate treatment, but is downregulated following treatment with 0.070 or 0.280 mM salicylate. Treatment with 0.140 mM salicylate results in 1.81, 1.04, and 2.41fold increased expression at 24, 48, and 72 h, respectively. The lowest expression level in the 0.070 mM treatment is detected at 24 h and corresponds to a decrease of 99.4%, while the lowest level in the 0.280 mM is observed at 72 h and corresponds to a 66% decrease. A non-significant 1.04fold increase at 48 h constitutes the lowest expression level in the 0.140 mM treatment
-
expression of ICS is significantly upregulated by 38-53% under salt stress. ICS gene expression is upregulated after 0.140 mM salicylate treatment, but is downregulated following treatment with 0.070 or 0.280 mM salicylate. Treatment with 0.140 mM salicylate results in 1.81, 1.04, and 2.41fold increased expression at 24, 48, and 72 h, respectively. The lowest expression level in the 0.070 mM treatment is detected at 24 h and corresponds to a decrease of 99.4%, while the lowest level in the 0.280 mM is observed at 72 h and corresponds to a 66% decrease. A non-significant 1.04fold increase at 48 h constitutes the lowest expression level in the 0.140 mM treatment
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isozyme ICS1 expression is induced throughout the leaf by exogenous salicylate and virus infection. i.e. cucumber mosaic virus but not with tobacco mosaic virus
isozyme ICS1 expression is positively regulated by TCP family transcription factor AtTCP8, e.g. under pathogen attack of Pseudomonas syringae pv. maculicola ES4326. TCP8/TCP9 positively regulate ICS1 expression with redundancy upon pathogen infection, and TCPs are involved in maintaining ICS1 expression
isozyme ICS2 expression is not induced by salicylate, the AtICS2 promoter activity is not stimulated by virus infection
prevention of NPR1 nuclear localization causes over-accumulation of ICS1 transcripts in response to pathogen infection
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the enzyme expression is induced after wounding, salt stress, and by salicylic acid
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